A prospective, randomized, double-blind comparison of epidural levobupivacaine 0.5% with epidural ropivacaine 0.75% for lower limb procedures

Peduto, V. A.; Baroncini, S; Montanini, S; Proietti, R.; Rosignoli, L.; Tufano, R; Casati, Andrea

doi:10.1097/00003643-200312000-00008

Cited by 45 publications

(14 citation statements)

References 20 publications

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“…The study done by Casati et al 9 Senard et al 23 Rao et al 10 also found insignificant changes in haemodynamic parameters on using comparable concentrations of levobupivacine and ropivacaine in their studies.…”

Section: Haemodynamic Changesmentioning

confidence: 85%

“…7 This is also evidenced by other studies; comparable results were found by many studies using low concentrations of Levobupivacaine and high concentrations of Ropivacaine. Peduto et al, 8 (epidural levobupivacaine 0.5% vs epidural ropivacaine 0.75%), Casati et al, 9 (PCEA levobupivacaine 0.125% vs PCEA ropivacaine 0.2%), Rao et al, 10 (epidural levobupivacaine 0.5% vs epidural ropivacaine 0.75%).…”

Section: Discussionmentioning

confidence: 99%

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A clinical comparative study of 0.2% levobupivacaine with 25 mcg fentanyl versus 0.2% ropivacaine with 25 mcg fentanyl for post-operative epidural analgesia in patients undergoing lower limb orthopaedic surgeries

Boregowda¹,

Linganna²,

Raju³

2020

IJCA

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A clinical comparative study of 0.2% levobupivacaine with 25 mcg fentanyl versus 0.2% ropivacaine with 25 mcg fentanyl for post-operative epidural analgesia in patients undergoing lower limb orthopaedic surgeries Abstract Objectives: The objectives of our study were to compare the efficacy and safety of 0.2% Levobupivacaine with 25 mcg Fentanyl and 0.2% Ropivacaine with 25 mcg Fentanyl given epidurally for post-operative analgesia in patients who were operated electively for lower limb orthopaedic conditions under spinal anaesthesia. Materials and Methods:Sixty patients belonging to American Society of Anaesthesiologists (ASA) Class I and II of both sexes, of age within 20 -60 years were included in the study after obtaining institutional ethical committee clearance. Patients were divided randomly into 2 groups: Group -LF which received 8 ml of 0.2% Levobupivacaine with 25 mcg Fentanyl and Group -RF which received 8 ml of 0.2% Ropivacaine with 25 mcg Fentanyl. Surgery was conducted under spinal anaesthesia. Later 8 ml of the test drug combination was given epidurally in the post-operative period when the patient complained of pain (VAS score > 4) and the parameters were recorded periodically until pain reappeared (VAS score > 4). Results:In both the groups mean duration of surgery, changes in haemodynamics and demographic profiles were comparable. However the total duration of post-operative analgesia in Levobupivacaine group was 325 +/-63.06 minutes and in Ropivacaine group was 210 +/-24.91 minutes respectively and this appeared to be statistically significant. Conclusion: Compared to 0.2% Ropivacine with 25 mcg Fentanyl, 0.2% Levobupivacaine with 25 mcg Fentanyl provides intense and longer duration of post-operative analgesia with similar haemodynamic stability.

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Section: Haemodynamic Changesmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

A clinical comparative study of 0.2% levobupivacaine with 25 mcg fentanyl versus 0.2% ropivacaine with 25 mcg fentanyl for post-operative epidural analgesia in patients undergoing lower limb orthopaedic surgeries

Boregowda¹,

Linganna²,

Raju³

2020

IJCA

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“…Levobupivacaine and Ropivacaine are some of these drugs that have been found off late. 15,16 Levobupivacaine, a long-acting local anaesthetic, has been developed as an alternative to bupivacaine, after the numerous complications reported by its predecessor. Numerous researches have been carried out to assess the various advantages and disadvantages of the newer drug.…”

Section: Discussionmentioning

confidence: 99%

Intraoperative haemodynamic profile in patients undergoing lower limb and abdominal surgery under subarachnoid block using 0.5% hyperbaric levobupivacaine: an observational study

2017

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Background: The aim of this study was to detect if intrathecal hyperbaric Levobupivacaine provided anaesthesia with more stable hemodynamic profile than 0.5% Hyperbaric Bupivacaine for lower limb and abdominal surgery.Methods: This observational study was carried out on 60 Adult patients between 18-65 Years of age, in ASA I and II undergoing lower abdominal surgery. Subarachnoid block using 3.0 ml of 0.5% hyperbaric Levobupivacaine (15 mg) was used as anaesthesia for surgery. Vitals recorded first in operation theatre were taken as baseline and were compared with subsequent readings till closure to judge the fall in blood pressure. Frequencies of parameters falling more than 30% from baseline, amount of IV fluids, vasopressors administered and complications were recorded. The data collected was displayed as mean with a standard deviation and frequency with percentage. Statistical analysis was performed using in stat computer software.Results: On analysis of the data it was found that fall in hemodynamic parameters was significantly lower in the Levobupivacaine group. It was observed that maximum onset of motor block was after 5 minutes, VAS after 4 minutes and loss of pinprick sensation was achieved at T-4 level after 4 minutes. Haemodynamic complications, which required therapeutic interventions, were hypotension (5%), bradycardia (3%), a total of 8%, who required urgent intervention as vasopressors and inotropes.Conclusions: 0.5% Hyperbaric Levobupivacaine, has onset of action similar to other local anaesthetics used for subarachnoid block, but has better hemodynamic profile in comparison to Hyperbaric 0.5% Bupivacaine, the commonly used local anaesthetic agent used for Spinal Anaesthesia.

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“…In a study conducted by Casati et al, where they compared epidural 0.5% Levobupivacaine with 0.5% Ropivacaine and concluded Levobupivacaine is having similar onset, quality, duration and better motor blockade when compared to Ropivacaine. 19 An increase in concentration resulted in a profound motor blockade. In a study by Finucane et al, in terms of motor block Bupivacaine group was observed to be significantly of better quality at certain times in comparison with Ropivacaine group.…”

Section: Sensory and Motor Parametersmentioning

confidence: 99%

“…This may be due to lower lipid solubility of Ropivacaine. [18][19][20][21] In a study conducted by Peduto et al, where they compared epidural levobupivacaine 0.5% with ropivacaine 0.75% for lower limb procedures, it was concluded same clinical profile is seen in both drugs. 22 It was observed by Karz J A et al that, no significant difference was found in motor or sensory effects with 0.5% Bupivacaine with 0.75% Ropivacaine given epidurally which proves their equipotency at different concentration.…”

Section: Sensory and Motor Parametersmentioning

confidence: 99%

The efficacy of epidural ropivacaine 0.75% and levobupivacaine 0.5% in abdominal and lower limb surgeries- a comparative study

Kumar

Rao

2016

Int J Res Med Sci

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A prospective, randomized, double-blind comparison of epidural levobupivacaine 0.5% with epidural ropivacaine 0.75% for lower limb procedures

Cited by 45 publications

References 20 publications

A clinical comparative study of 0.2% levobupivacaine with 25 mcg fentanyl versus 0.2% ropivacaine with 25 mcg fentanyl for post-operative epidural analgesia in patients undergoing lower limb orthopaedic surgeries

A clinical comparative study of 0.2% levobupivacaine with 25 mcg fentanyl versus 0.2% ropivacaine with 25 mcg fentanyl for post-operative epidural analgesia in patients undergoing lower limb orthopaedic surgeries

Intraoperative haemodynamic profile in patients undergoing lower limb and abdominal surgery under subarachnoid block using 0.5% hyperbaric levobupivacaine: an observational study

The efficacy of epidural ropivacaine 0.75% and levobupivacaine 0.5% in abdominal and lower limb surgeries- a comparative study

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