A prospective randomized double‐blind trial of grape juice antioxidants in men with lower urinary tract symptoms

Spettel, Sara; Chughtai, Bilal; Feustel, Paul J.; Kaufman, Anna; Levin, Robert M.; De, Elise

doi:10.1002/nau.22289

Cited by 6 publications

(3 citation statements)

References 31 publications

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“…Grapes ( Vitis vinifera ) and grape juice have also been studied in relation to PCa, due to the major phenolic antioxidants content (in grape skin and seeds extract) [ 138 ]. In the only double-blind published RCT to date ( Table 6 ), Spettel et al [ 133 ] compared the effects of the daily intake of 240 mL 100% Concord grape juice with placebo for a total of 3 months. The trial failed to report changes in PSA concentrations between the two interventions.…”

Section: Antioxidants and Psa Kineticsmentioning

confidence: 99%

Dietary Factors and Supplements Influencing Prostate-Specific Antigen (PSA) Concentrations in Men with Prostate Cancer and Increased Cancer Risk: An Evidence Analysis Review Based on Randomized Controlled Trials

et al. 2020

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The quest for dietary patterns and supplements efficient in down-regulating prostate-specific antigen (PSA) concentrations among men with prostate cancer (PCa) or increased PCa risk has been long. Several antioxidants, including lycopene, selenium, curcumin, coenzyme Q10, phytoestrogens (including isoflavones and flavonoids), green tea catechins, cernitin, vitamins (C, E, D) and multivitamins, medicinal mushrooms (Ganoderma lucidum), fruit extracts (saw palmetto, cranberries, pomegranate), walnuts and fatty acids, as well as combined supplementations of all, have been examined in randomized controlled trials (RCTs) in humans, on the primary, secondary, and tertiary PCa prevention level. Despite the plethora of trials and the variety of examined interventions, the evidence supporting the efficacy of most dietary factors appears inadequate to recommend their use.

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Section: Antioxidants and Psa Kineticsmentioning

confidence: 99%

Dietary Factors and Supplements Influencing Prostate-Specific Antigen (PSA) Concentrations in Men with Prostate Cancer and Increased Cancer Risk: An Evidence Analysis Review Based on Randomized Controlled Trials

et al. 2020

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“…A Concord grape juice was overall not effective at reducing LUTS in men over 45 years old, albeit an improvement in Q max . These results might be due the length of the study, as well as a low concentration in antioxidant compounds [19].…”

Section: Discussionmentioning

confidence: 99%

Cranberry fruit powder (Flowens™) improves lower urinary tract symptoms in men: a double-blind, randomized, placebo-controlled study

Vidlář

Vostalová

Fromentin³

et al. 2015

World J Urol

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“…In a nonrandomized study of Italian men using 120 mg of a standardized cranberry extract (Anthocran) daily for 60 days, it was found that the intervention group (n ¼ 23) significantly reduced the number of urinary tract infection episodes (from 3.2 to 0.8; p < .05) during the intervention compared with the control group (n ¼ 21; from 3.1 to 2.1; Ledda et al, 2016). In a randomized double-blind trial of 96 American men with LUTS, men taking 240 ml of 100% grape juice daily for 3 months (n ¼ 47) showed no significant difference in LUTS compared with men in the control group (n ¼ 49; Spettel et al, 2013). However, in the BACH study, citrus juice intake was found to be significantly associated with a 50% lower chance of LUTS progression in men, while greater coffee or baseline total caffeine intake significantly increased the chance of LUTS progression (Maserejian et al, 2013b).…”

Section: Alternative Treatments Of Luts Worldwidementioning

confidence: 99%

Prevalence, Burden, and Treatment of Lower Urinary Tract Symptoms in Men Aged 50 and Older: A Systematic Review of the Literature

Zhang

2018

SAGE Open Nursing

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We conducted a systematic review of literature from the years 2000 through 2017 on the prevalence and burden of lower urinary tract symptoms (LUTS) in men aged 50 and older, and medical treatments of and alternative nonmedical approaches to LUTS. EBSCOhost (Medline with Full Text) was searched for observational, experimental, and review studies in peerreviewed journals in the English language. Our review found that LUTS were highly prevalent in the world and estimated to affect 2.3 billion people in 2018, with 44.7% being men. Men with LUTS suffer from not only burdensome symptoms such as nocturia and urgency but also adverse psychological consequences (e.g., anxiety and depression) and financial burden. Current medical treatments are clinically effective, but their efficacy is compromised by side effects and low compliance rates. Alternative nonmedical treatments for LUTS were also sought worldwide. There is evidence that lifestyle modifications such as pelvic muscle exercises and bladder training, physical activity, dietary modification, and nutritional supplements can alleviate LUTS and improve patient quality of life; however, evidence based on rigorous methodology remains minimal and cannot be generalized across populations. Evidence of effectiveness of weight loss programs to reduce LUTS is inconclusive. We conclude that although behavioral treatment is a promising approach to alleviating LUTS, especially when combined with medical treatments, well-designed randomized controlled and longitudinal clinical trials on behavioral treatments of LUTS are still needed. Minimally invasive procedures and neuromodulation therapy also show positive results of alleviating LUTS but require further research as well.

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A prospective randomized double‐blind trial of grape juice antioxidants in men with lower urinary tract symptoms

Abstract: Our study did not demonstrate any difference in LUTS in men taking a daily 240 ml 100% grape juice versus placebo after 3 months.

Cited by 6 publications

References 31 publications

Dietary Factors and Supplements Influencing Prostate-Specific Antigen (PSA) Concentrations in Men with Prostate Cancer and Increased Cancer Risk: An Evidence Analysis Review Based on Randomized Controlled Trials

Dietary Factors and Supplements Influencing Prostate-Specific Antigen (PSA) Concentrations in Men with Prostate Cancer and Increased Cancer Risk: An Evidence Analysis Review Based on Randomized Controlled Trials

Cranberry fruit powder (Flowens™) improves lower urinary tract symptoms in men: a double-blind, randomized, placebo-controlled study

Prevalence, Burden, and Treatment of Lower Urinary Tract Symptoms in Men Aged 50 and Older: A Systematic Review of the Literature

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