A prospective randomized double-blind trial on efficacy of dexamethasone for endodontic interappointment pain in teeth with asymptomatic inflamed pulps

Effect of Pretreatment Prednisolone on Postendodontic Pain: A Double-blind Parallel-randomized Clinical Trial

“…In the present study, the placebo did not result in significant pain reduction at the 24-hour time point. These results were different considering other published studies (1,4,15,24). In comparison with placebo at the 6-, 12-, and 24-hour time points, prednisolone was able to significantly reduce pain intensity.…”

“…The dental literature presents few studies evaluating oral administration of glucocorticoids for the prevention and control of postendodontic pain (1,14,(24)(25)(26) and no evaluations with oral prednisolone. Protocols for assessing endodontic pain differ from oral surgery models in several respects.…”

“…Nevertheless, few studies have evaluated the effect of SAIDs with regard to prevention and control of postendodontic pain after root canal instrumentation (1,(24)(25)(26). The optimal oral prednisolone dosage for the prevention and control of interappointment endodontic pain is yet to be determined.…”

Retracted: Postoperative pain after irrigation with Vibringe versus a conventional needle: a randomized controlled trial

“…Pain following root canal treatment occurs with a highly variable prevalence ranging from 10.6% (Oliet 1983) to 82.9% (Glassman et al 1989). During canal cleaning, shaping or filling procedures, extrusion of microorganisms or debris is common and has been reported to worsen the inflammatory response and cause periradicular inflammation (Cunningham & Mullaney 1992, Arias et al 2013.…”

Efficacy comparison of periapical infiltration injection of dexamethasone, morphine and placebo for postoperative endodontic pain

“…This anti-pain effect gradually receded after the first day, so that no significant effect was perceived after 48 h. Such a duration of effect seems to be sufficient for the relief of postendodontic pain, as it has been shown that the pain reaches its maximum within the first 24 h after operation 9,10,23 . Dexamethasone is a powerful anti-inflammatory agent that can reduce postendodontic pain, as described in previous studies 10,[24][25][26] . Marshall et al 9 have reported that the administration of 4 mg of dexamethasone considerably decreases postoperative endodontic pain.…”