A prospective randomized single blind trial of Fleet phosphate enema versus glycerin suppositories as preparation for flexible sigmoidoscopy

Underwood, Diana; Makar, Ragai R.; Gidwani, A. L.; Najfi, Syed Muzahir; Neilly, Paul; Gilliland, R.

doi:10.1007/s11845-009-0403-8

Cited by 11 publications

(4 citation statements)

References 13 publications

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“…Moreover, the physicians grated the quality of preparation as excellent in 67% among the patients in the enema group as compared with only 17% in the glycerin group. 15 These results are in line with our findings, although the difference between the suppositories and enema was less evident in our study.…”

Section: Discussionsupporting

confidence: 92%

Clinical trial: free fatty acid suppositories compared with enema as bowel preparation for flexible sigmoidoscopy

Ormarsson

Ásgrimsdóttir

Loftsson

et al. 2014

Frontline Gastroenterol

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ObjectivesThe purpose of this trial was to evaluate the efficacy and safety of recently developed suppositories containing free fatty acids as a bowel-cleansing agent prior to flexible sigmoidoscopy and compare them with Klyx (docusate sodium/sorbitol).DesignA controlled, non-inferiority, single-blind, randomised study on outpatients undergoing flexible sigmoidoscopy.SettingDepartment of Gastroenterology, Landspitali-University Hospital and endoscopic clinic.Patients53 outpatients undergoing flexible sigmoidoscopy.InterventionParticipants were randomised to receive either free fatty acid suppositories (28) or a standard bowel preparation with Klyx enema (25). In the study group, two suppositories were administered the evening before as well as 2 h prior to the sigmoidoscopy. In the control group, Klyx enema (120 mL) was administered the evening before and repeated 2 h prior to the procedure.Main outcome measurementsQuality of the bowel cleansing, height of scope insertion and safety.ResultsThe mean height of scope insertion and bowel cleansing was 43 cm (SD=13.4) in the study group and 48 cm (SD=10.4) in the control group (NS). The investigating physicians were less satisfied with the bowel preparation in the study group compared with the control group with a difference of 20% (p<0.016). The amount of faeces noted in the rectum was similar in both groups with no significant difference (p<0.56). No serious side effects, toxic reaction or irritation were observed.ConclusionsThe suppositories are well tolerated with no significant side effects. The suppositories had distinct bowel emptying effect and as effective as Klyx in rectal cleansing. Although physician's satisfaction was slightly lower, the height of scope insertion was similar.Trial registration numberEudraCT nr.: 2010-018761-35.

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Section: Discussionsupporting

confidence: 92%

Clinical trial: free fatty acid suppositories compared with enema as bowel preparation for flexible sigmoidoscopy

Ormarsson

Ásgrimsdóttir

Loftsson

et al. 2014

Frontline Gastroenterol

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“…Although oral lavage solutions are more effective than enemas,129,130 1 or 2 sodium phosphate enemas are frequently used based on phy-sician preference 126,131-133. Although the insertion depth may be subjective,134 it is generally recommended to observe at least beyond the splenic flexure or at least 40 cm from the analverge when the endoscope is straightened 126…”

Section: Epidemiology Of Colorectal Cancers and Colorectal Adenomas Imentioning

confidence: 99%

Korean Guidelines for Colorectal Cancer Screening and Polyp Detection

Lee

Hong

Kim³

et al. 2012

Clin Endosc

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Now colorectal cancer is the second most common cancer in males and the fourth most common cancer in females in Korea. Since most of colorectal cancers occur after the prolonged transformation of adenomas into carcinomas, early detection and removal of colorectal adenomas are one of the most effective methods to prevent colorectal cancer. Considering the increasing incidence of colorectal cancer and polyps in Korea, it is very important to establish Korean guideline for colorectal cancer screening and polyp detection. The guideline was developed by the Korean Multi-Society Take Force and we tried to establish the guideline by evidence-based methods. Parts of the statements were draw by systematic reviews and meta-analyses. Herein we discussed epidemiology of colorectal cancers and adenomas in Korea and optimal methods for screening of colorectal cancer and detection of adenomas including fecal occult blood tests, radiologic tests, and endoscopic examinations.

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“…Although oral lavage solutions are more effective than enemas, 129,130 1 or 2 sodium phosphate enemas are frequently used based on physician preference. 126,[131][132][133] Although the insertion depth may be subjective, 134 it is generally recommended to observe at least beyond the splenic flexure or at least 40 cm from the anal verge when the endoscope is straightened. 126 If any adenomas are identified by sigmoidoscopy, it is necessary to recommend colonoscopy regardless of the adenoma size because the possibility of proximal tumors increases even if the adenoma is small.…”

Section: ) Sigmoidoscopymentioning

confidence: 99%

Korean Guidelines for Colorectal Cancer Screening and Polyp Detection

Lee

Hong

Kim

et al. 2012

J Korean Soc Radiol

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According to the statistical yearbook of the Ministry of Health and Welfare, crude colorectal cancer incidence rates in Korea in 2008 were 54.7 and 36.9 per 100,000 among males and females, respectively. Colorectal cancer is thus the second most common cancer in males and the fourth most common Clin Endosc 2012;45:25-43 Copyright © 2012 The Korean Society of Gastrointestinal Endoscopy 25 cancer in females. 1 The mortality rates (the number of deaths per 100,000 people, %) of colorectal cancer in 2008 were 15.4% among males and 12.1% among females. Colorectal cancer is thus the fourth most common cause of cancer death among Korean males and the second most common cause of cancer death among Korean females. The age-standardized mortality rates of colorectal cancer continue to increase, unlike those of other common cancers, including lung cancer, liver cancer and stomach cancer, whose mortality rates have decreased in recent years. Increases in the incidence of colorectal cancer may be partly due to Westernization of many Koreans' lifestyles. Greater public awareness of colorectal cancer and the addition of colorectal cancer in 2004 to the national cancer screening program are likely also responsible in part for the increased incidence rates. Participation rates in the national colorectal screening program increased from ap Now colorectal cancer is the second most common cancer in males and the fourth most common cancer in females in Korea. Since most of colorectal cancers occur after the prolonged transformation of adenomas into carcinomas, early detection and removal of colorectal adenomas are one of the most effective methods to prevent colorectal cancer. Considering the increasing incidence of colorectal cancer and polyps in Korea, it is very important to establish Korean guideline for colorectal cancer screening and polyp detection. The guideline was developed by the Korean Multi-Society Take Force and we tried to establish the guideline by evidence-based methods. Parts of the statements were draw by systematic reviews and meta-analyses. Herein we discussed epidemiology of colorectal cancers and adenomas in Korea and optimal methods for screening of colorectal cancer and detection of adenomas including fecal occult blood tests, radiologic tests, and endoscopic examinations.

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A prospective randomized single blind trial of Fleet phosphate enema versus glycerin suppositories as preparation for flexible sigmoidoscopy

Abstract: Bowel preparation for flexible sigmoidoscopy using a single Fleet enema is acceptable to patients and more effective than glycerin suppositories.

Cited by 11 publications

References 13 publications

Clinical trial: free fatty acid suppositories compared with enema as bowel preparation for flexible sigmoidoscopy

Clinical trial: free fatty acid suppositories compared with enema as bowel preparation for flexible sigmoidoscopy

Korean Guidelines for Colorectal Cancer Screening and Polyp Detection

Korean Guidelines for Colorectal Cancer Screening and Polyp Detection

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