A prospective study: hyperbaric oxygen therapy in diabetics with chronic foot ulcers

Löndahl, Magnus; Katzman, Per; Nilsson, Anders; Hammarlund, Christer; Sellman, Anders; Wykman, Anders; Hugo-Persson, M; Apelqvist, Jan

doi:10.12968/jowc.2006.15.10.26970

Cited by 23 publications

(18 citation statements)

References 23 publications

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“…Many studies used different adjunctive therapies with the intention to cure the diabetic skin ulcers including HBO [13,18,20,29], ultrasound [1], recombinant platelet-derived growth factor-BB [22], vacuumassisted wound closure [17,21], and acellular matrix [16]. Among them, HBO is the most commonly used modality at our institution.…”

Section: Discussionmentioning

confidence: 99%

Extracorporeal Shockwave Treatment for Chronic Diabetic Foot Ulcers

Wang

Kuo

et al. 2009

Journal of Surgical Research

118

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Section: Discussionmentioning

confidence: 99%

Extracorporeal Shockwave Treatment for Chronic Diabetic Foot Ulcers

Wang

Kuo

et al. 2009

Journal of Surgical Research

118

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“…Design and rationale of the HODFU study and results of ulcer healing outcome have been reported in detail previously [5,6]. All HODFU study participants who completed therapy, predefined as receiving at least 36 out of 40 scheduled HBOT/placebo sessions, were included in this study (n=75 out of 94).…”

Section: Methodsmentioning

confidence: 99%

“…In the randomised, double-blind, placebo-controlled Hyperbaric Oxygen Treatment in Diabetic Patients with Chronic Foot Ulcers (HODFU) study, the effect of HBOT in diabetic patients with chronic foot ulcers Wagner grade 2, 3 and 4 was compared with the effect of hyperbaric air therapy (placebo) [5]. This study showed a beneficial effect of HBOT [6].…”

Section: Introductionmentioning

confidence: 99%

Relationship between ulcer healing after hyperbaric oxygen therapy and transcutaneous oximetry, toe blood pressure and ankle–brachial index in patients with diabetes and chronic foot ulcers

et al. 2010

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Aims/hypothesis The randomised, double-blind, placebocontrolled Hyperbaric Oxygen Therapy (HBOT) in Diabetic Patients with Chronic Foot Ulcers (HODFU) study showed beneficial effect of HBOT. As this treatment is expensive and time-consuming, being able to select patients for therapy would be very useful. The aim of this study was to evaluate whether circulatory variables could help in predicting outcome of HBOT. Methods All HODFU study participants who completed therapy, predefined as receiving at least 36 out of 40 scheduled HBOT/placebo sessions, were included in this study (n=75). Baseline transcutaneous oximetry (TcPO 2 ), toe blood pressure (TBP) and ankle-brachial index (ABI) were measured. Ulcer healing rate was registered at the 9-month follow-up visit. An ulcer was considered healed when it was completely epithelialised and remained so at the 12-month follow-up. ResultsIn the HBOT group TcPO 2 were significantly lower for patients whose ulcer did not heal as compared with those whose ulcers healed. A significantly increased healing frequency was seen with increasing TcPO 2 levels in the HBOT group (TcPO 2 /healing rate: <25 mmHg/0%; 26-50 mmHg/50%; 51-75 mmHg/73%; and >75 mmHg/ 100%). No statistically significant relation between the level of TBP or ABI and healing frequency was seen. Conclusions/interpretation Our results indicate that TcPO 2 in contrast to ABI and TBP correlates to ulcer healing following HBOT. We suggest HBOT as a feasible adjunctive treatment modality in diabetic patients with chronic non-healing foot ulcers when basal TcPO 2 at the dorsum of the foot is above 25 mmHg. Trial registration NCT00953186 Funding Mrs

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“…HBOT is mostly performed in developed countries, such as USA and UK. According to SF-36 instrument, HBOT improves vitality, physical function, body pain, total health perceptions, mental health and physical, emotional, and social role functioning in patients with troublesome diseases (15,17,19,21,27).…”

Section: Discussionmentioning

confidence: 99%

Hyperbaric Oxygen Therapy and Quality of Life: A Systematic Review

Nourmohammadi

Doaee

Fazel

et al. 2017

Ann Mil Health Sci Res

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Objective: Hyperbaric oxygen therapy (HBOT) involves breathing pure oxygen in a high-pressure chamber. HBOT is a wellestablished treatment for several diseases, such as serious infections, chronic diabetic foot ulcer, radiation injury, and hidradenitis suppurativa. There are various troublesome diseases that decrease pleasure in life in patients. HBOT has excellent effects in improving QOL in patients with acute and chronic diseases. The present study aimed at assessing the researches that focus on improving the QOL after HBO treatments. Methods:A systematic quest was conducted to evaluate English papers (clinical trials) that were published before April 2017. We searched PubMed, institute of scientific information (ISI), SCOPUS, Web of Science, Ovid, Science direct, ProQuest, Wiley, Cochran, Ebsco host, and Google Scholar. The reference lists of all the articles and electronic journals were searched for further studies. The JAMA users guide evaluation scales for RCTs was used to assess quality of the researched articles. Inclusion and exclusion criteria were extracted according to the scientific criteria. Sample size was 806 patients.Results: Finally, 15 published articles were extracted. Most researches were done in UK (26.7%), Israel (20%), and Sweden (20%). The mean age in HBOT group was 41.88, with a male to female ratio of 1.52. The mean age in the control group was 38.29, with a male to female ratio of 2.14. The most frequent clinical trials were those on the treatment of diabetic foot ulcer (20%), post-concussion syndrome (13.3%), pelvic radiotherapy (13.3%), and chronic arm lymphedema after radiotherapy (13.3%). The most QOL questionnaires used were SF-36 (21.4%), EORTC (European organization for research and treatment of cancer) QLQ-C30, head and neck cancer module (H&N35), and performance status scale (PSS).Conclusions: A significant effect of HBOT on improving QOL in patients' outcomes and symptoms was found compared with the control group. We found improved QOL in patients with diabetic foot ulcer, post-concussion syndrome, pelvic radiotherapy, post stroke, hidradenitis suppurativa, tonsillar fossa tumor radiotherapy, jaw osteonecrosis, and fibromyalgia syndrome. We suggest that HBOT be added to conventional treatment of these patients as an adjuvant.

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A prospective study: hyperbaric oxygen therapy in diabetics with chronic foot ulcers

Abstract: Research suggests that hyperbaric oxygen therapy may have beneficial effects on ulcer healing and amputation rates in diabetic patients. This paper describes the design of a study that is evaluating its effects on chronic diabetic foot ulcers.

Cited by 23 publications

References 23 publications

Extracorporeal Shockwave Treatment for Chronic Diabetic Foot Ulcers

Extracorporeal Shockwave Treatment for Chronic Diabetic Foot Ulcers

Relationship between ulcer healing after hyperbaric oxygen therapy and transcutaneous oximetry, toe blood pressure and ankle–brachial index in patients with diabetes and chronic foot ulcers

Hyperbaric Oxygen Therapy and Quality of Life: A Systematic Review

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