A prospective study of adherence and viral load in a large multi-center cohort of HIV-infected women

Howard, Andrea A.; Arnsten, Julia H.; Lo, Yungtai; Vlahov, David; Rich, Josiah D.; Schuman, Paula; Stone, Valerie E.; Smith, Dawn K.; Schoenbaum, Ellie E.

doi:10.1097/00002030-200211080-00010

Cited by 250 publications

(197 citation statements)

References 23 publications

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“…26 Although reported barriers to adherence are consistent across multiple settings and countries, studies have also shown that adherence levels and the profile of factors that influence it differ by settings. [27][28][29] were allocated a number. Coupons bearing these numbers were put in a hat and randomly drawn to make the selection of the 10 to participate in the study.…”

Section: Introductionmentioning

confidence: 99%

Adherence to antiretroviral therapy, virologic failure and workload at the Rustenburg Provincial Hospital

Chabikuli

Datonye

Nachega

et al. 2010

South African Family Practice

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SA Fam Pract 2010;52(4):350-355Background: Adherence to antiretroviral therapy (ART) is a strong predictor of progression to AIDS and death. It remains the most important potentially alterable factor that determines treatment outcomes. Methods:The study is a cross-sectional survey of self-reported adherence to ART and associated factors. The clinic had a tenfold increase in patient enrolment and a ninefold decline in staff-to-patient ratio, and the proportion of patients lost to follow-up doubled in the preceding four years.Conclusion: Adherence to ART was poor. The capacity of the clinic to manage patients adequately has declined significantly. Decentralisation of ART services to primary health care facilities should be considered.Peer reviewed.

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Section: Introductionmentioning

confidence: 99%

Adherence to antiretroviral therapy, virologic failure and workload at the Rustenburg Provincial Hospital

Chabikuli

Datonye

Nachega

et al. 2010

South African Family Practice

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“…Paterson et al (2000) found that approximately 30% of patients were able to achieve this level, and Golin and colleagues (2002) found that only 4% of patients took 95% or more of their medications consistently. In addition, adherence rates tend to decline over time (Howard et al 2002;Ickovics et al 2002).…”

Section: Introductionmentioning

confidence: 99%

Adherence to Antiretroviral Medication Regimens: A Test of a Psychosocial Model

et al. 2007

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Objective-The primary aim of this study was to test a psychosocial model of medication adherence among people taking antiretroviral medications. This model was based primarily on social cognitive theory and included personal (self-efficacy, outcome expectancy, stigma, depression, and spirituality), social (social support, difficult life circumstances), and provider (patient satisfaction and decision-making) variables. © Springer Science+Business Media, LLC 2007Correspondence to: Colleen DiIorio, cdiiori@sph.emory.edu. Design-The data for this analysis were obtained from the parent study, which was a randomized controlled trial (Get Busy Living) designed to evaluate an intervention to foster medication adherence. Factor analysis was used to develop the constructs for the model, and structural equation modeling was used to test the model. Only baseline data were used in this cross sectional analysis. NIH Public AccessMethods-Participants were recruited from a HIV/AIDS clinic in Atlanta, GA. Prior to group assignment, participants were asked to complete a questionnaire that included assessment of the study variables.Results-A total of 236 participants were included in the analysis. The mean age of the participants was 41 years; the majority were male, and most were African-American. In the final model, self-efficacy and depression demonstrated direct associations with adherence; whereas stigma, patient satisfaction, and social support were indirectly related to adherence through their association with either self-efficacy or depression.Conclusion-These findings provide evidence to reinforce the belief that medication-taking behaviors are affected by a complex set of interactions among psychosocial variables and provide direction for adherence interventions.

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“…The medication outcome typically most important to the clinician is a sustained period of adherence by the patient, but ample evidence documents considerable variability in antiretroviral adherence [28]. Well-designed prospective studies have highlighted the limitations of using baseline patient characteristics to predict adherence trajectories.…”

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confidence: 99%

Antidepressant Treatment and Adherence to Combination Antiretroviral Therapy among Patients with AIDS and Diagnosed Depression

Walkup¹,

Wei²,

Sambamoorthi

et al. 2007

Psychiatr Q

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A prospective study of adherence and viral load in a large multi-center cohort of HIV-infected women

Abstract: Antiretroviral adherence is not stable over time. Interventions aimed at monitoring and improving long-term adherence in women are urgently needed.

Cited by 250 publications

References 23 publications

Adherence to antiretroviral therapy, virologic failure and workload at the Rustenburg Provincial Hospital

Adherence to antiretroviral therapy, virologic failure and workload at the Rustenburg Provincial Hospital

Adherence to Antiretroviral Medication Regimens: A Test of a Psychosocial Model

Antidepressant Treatment and Adherence to Combination Antiretroviral Therapy among Patients with AIDS and Diagnosed Depression

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