A Prospective Study of Autistic-Like Traits in Unaffected Siblings of Probands With Autism Spectrum Disorder

Georgiades, Stelios; Szatmári, Péter; Zwaigenbaum, Lonnie; Bryson, Susan W.; Brian, Jessica; Roberts, Wendy; Smith, Isabel M.; Vaillancourt, Tracy; Roncadin, Caroline; Garon, Nancy

doi:10.1001/2013.jamapsychiatry.1

Cited by 113 publications

(106 citation statements)

References 41 publications

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“…Data on inter-rater reliability was good, test-retest reliability less so, but the sample size was only 20 81 and thus judged to be of poor methodological quality. Georgiades et al 82 found good discrimination between high-and low-risk infants (i.e. infant siblings of children with ASD vs. no ASD).…”

Section: Autism Observation Scale For Infantsmentioning

confidence: 99%

Systematic review of tools to measure outcomes for young children with autism spectrum disorder

McConachie

Parr

Glod

et al. 2015

Health Technology Assessment

236

261

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BackgroundThe needs of children with autism spectrum disorder (ASD) are complex and this is reflected in the number and diversity of outcomes assessed and measurement tools used to collect evidence about children’s progress. Relevant outcomes include improvement in core ASD impairments, such as communication, social awareness, sensory sensitivities and repetitiveness; skills such as social functioning and play; participation outcomes such as social inclusion; and parent and family impact.ObjectivesTo examine the measurement properties of tools used to measure progress and outcomes in children with ASD up to the age of 6 years. To identify outcome areas regarded as important by people with ASD and parents.MethodsThe MeASURe (Measurement in Autism Spectrum disorder Under Review) research collaboration included ASD experts and review methodologists. We undertook systematic review of tools used in ASD early intervention and observational studies from 1992 to 2013; systematic review, using the COSMIN checklist (Consensus-based Standards for the selection of health Measurement Instruments) of papers addressing the measurement properties of identified tools in children with ASD; and synthesis of evidence and gaps. The review design and process was informed throughout by consultation with stakeholders including parents, young people with ASD, clinicians and researchers.ResultsThe conceptual framework developed for the review was drawn from the International Classification of Functioning, Disability and Health, including the domains ‘Impairments’, ‘Activity Level Indicators’, ‘Participation’, and ‘Family Measures’. In review 1, 10,154 papers were sifted – 3091 by full text – and data extracted from 184; in total, 131 tools were identified, excluding observational coding, study-specific measures and those not in English. In review 2, 2665 papers were sifted and data concerning measurement properties of 57 (43%) tools were extracted from 128 papers. Evidence for the measurement properties of the reviewed tools was combined with information about their accessibility and presentation. Twelve tools were identified as having the strongest supporting evidence, the majority measuring autism characteristics and problem behaviour. The patchy evidence and limited scope of outcomes measured mean these tools do not constitute a ‘recommended battery’ for use. In particular, there is little evidence that the identified tools would be good at detecting change in intervention studies. The obvious gaps in available outcome measurement include well-being and participation outcomes for children, and family quality-of-life outcomes, domains particularly valued by our informants (young people with ASD and parents).ConclusionsThis is the first systematic review of the quality and appropriateness of tools designed to monitor progress and outcomes of young children with ASD. Although it was not possible to recommend fully robust tools at this stage, the review consolidates what is known about the field and will act as a benchmark for future developments. With input from parents and other stakeholders, recommendations are made about priority targets for research.Future workPriorities include development of a tool to measure child quality of life in ASD, and validation of a potential primary outcome tool for trials of early social communication intervention.Study registrationThis study is registered as PROSPERO CRD42012002223.FundingThe National Institute for Health Research Health Technology Assessment programme.

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Section: Autism Observation Scale For Infantsmentioning

confidence: 99%

Systematic review of tools to measure outcomes for young children with autism spectrum disorder

McConachie

Parr

Glod

et al. 2015

Health Technology Assessment

236

261

View full text Add to dashboard Cite

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“…3 In the United Kingdom (UK), the general practitioner (GP) is often the first port of call for parents or individuals seeking assistance for a suspected diagnosis of autism spectrum disorder (hereafter, "autism") (1). Responding to autism is a potentially challenging task for GPs.…”

Section: How This Fits Inmentioning

confidence: 99%

“…Changing definitions of autism (2), the substantial heterogeneity both between and within individuals (3), and the prevalence of co-occurring conditions in many autistic children and adults (4) all present serious difficulties to non-specialist clinicians.…”

Section: How This Fits Inmentioning

confidence: 99%

GPs’ confidence in caring for their patients on the autism spectrum: an online self-report study

et al. 2017

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“…Moreover, younger siblings of children with ASD demonstrate significant deficits on indices of social communicative development and cognitive functioning, as well as elevated ASD symptoms relative to younger siblings of typically developing children. [61][62][63][64] Because these children are at elevated risk, they require intensified developmental surveillance. At a minimum, they should receive continuous surveillance for developmental issues and be screened for ASD at 18 and 24 months of age, as recommended by the AAP for all children.…”

Section: Systematic Observation For Red Flagsmentioning

confidence: 99%

Early Screening of Autism Spectrum Disorder: Recommendations for Practice and Research

et al. 2015

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This article reviews current evidence for autism spectrum disorder (ASD) screening based on peer-reviewed articles published to December 2013. Screening provides a standardized process to ensure that children are systematically monitored for early signs of ASD to promote earlier diagnosis. The current review indicates that screening in children aged 18 to 24 months can assist in early detection, consistent with current American Academy of Pediatrics' recommendations. We identify ASD-specific and broadband screening tools that have been ev-aluated in large community samples which show particular promise in terms of accurate classification and clinical utility. We also suggest strategies to help overcome challenges to implementing ASD screening in community practice, as well as priorities for future research. Pediatrics 2015;136:S41-S59

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A Prospective Study of Autistic-Like Traits in Unaffected Siblings of Probands With Autism Spectrum Disorder

Cited by 113 publications

References 41 publications

Systematic review of tools to measure outcomes for young children with autism spectrum disorder

Systematic review of tools to measure outcomes for young children with autism spectrum disorder

GPs’ confidence in caring for their patients on the autism spectrum: an online self-report study

Early Screening of Autism Spectrum Disorder: Recommendations for Practice and Research

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