A Prospective Study of Drug Utilization Pattern of Anti-Epileptic Drugs and Their Adverse Effects in a Tertiary Care Hospital

T, Henry Daniel Raj; Sylvia, Andrea; Chidambaranathan, S.; Nirmala, P

doi:10.22159/ijcpr.2017v9i6.23427

Cited by 6 publications

(3 citation statements)

References 9 publications

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“…Sodium valproate was the mainstay of treatment in pediatric seizures. Side effects were minimal(10). In the present study, the most commonly used Antiepileptic drug was also Sodium valproate.…”

mentioning

confidence: 63%

Adverse Drug Reactions of Anti-Epileptic Drugs in Pediatric Age Group in a Tertiary Care Teaching Hospital; A Cross-Sectional Study

DAS

Sehgal

SINGH

2022

Asian J Pharm Clin Res

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Objectives: In this cross-sectional study, the aims were to analyze the incidence and pattern of adverse drug reactions (ADRs) of antiepileptic drugs in pediatric patient. Most common adverse effect and most common drug causing adverse effect were evaluated. Methods: Study was conducted over 60 Patients for 6 months in out-patient basis pediatric department in Rajindra Hospital associated with GMC, Patiala, a tertiary care teaching hospital in Punjab. The patient diagnosed by the Pediatrician with epilepsy who fulfilling inclusion and exclusion criteria was enrolled after taking informed consent. ADRs were noted using Pediatric Epilepsy Side Effect Questionnaire at clinic visit and any other adverse effects reported by patients. Results: In this study, a total of 60 children were enrolled. The mean age was 10.26±3.70, median were 11.00. 41 (68.33%) patients were boys and 19 (31.67%) were girls. In Cognitive ADRs with anti-epileptic drugs, there were total 17 ADRs reported. Valproate was causing most cognitive ADRs (32.43%). Among all cognitive ADRs, attention difficulty was the commonest complains. There were no motor and behavioral ADRs reported. Total 27 general neurological ADRs reported, which was highest reported ADRs. Among general neurological, Clobazam was causing highest ADRs (55.56%). 10 patients also reported tremor as another ADR and Clobazam causing most (22.22%). Conclusion: In the present study, boys were developing more epilepsy than girls. Valproate was causing most ADRs. Among all cognitive ADRs, attention difficulty was the most common ADR. General neurological ADRs were highest reported ADRs.

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confidence: 63%

Adverse Drug Reactions of Anti-Epileptic Drugs in Pediatric Age Group in a Tertiary Care Teaching Hospital; A Cross-Sectional Study

DAS

Sehgal

SINGH

2022

Asian J Pharm Clin Res

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“…Generalized tonic–clonic seizure (GTCS) was the most common form of seizure (48.35%) observed in our study. A majority of previous clinical studies have shown the dominance of this seizure type in children while a study conducted by Patel et al .…”

Section: Discussionmentioning

confidence: 97%

Evaluation and comparison of the utilization of anti‐epileptic drugs in Indian paediatric patients with global usage data

Panda

George

Parekh

et al. 2019

J Pharm Health Serv Res

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Objectives To evaluate the utilization pattern of anti-epileptic drugs (AEDs) in Indian paediatric patients and compare it with the global usage data. Methods Paediatric patients (≤18 years) with a confirmed diagnosis of epilepsy and prescribed with at least one AED were included in the study from a child neurology clinic in Pune, Maharashtra, India. The data pertaining to the type of epilepsy, and drug therapy was obtained retrospectively. The prescribing pattern of AEDs was identified and compared with the drug utilization pattern of the Asian and European countries from a systemic literature review. Key findings Out of the 343 paediatric patients enrolled in the study, 55.6% were males. Thirty-four per cent of the patients were under the age group of 2-6 years. More than half (60.5%) of the patients were diagnosed with generalized seizures, with tonic-clonic seizures (48%) being the most common among them. Out of the 37.9% of patients diagnosed with partial epilepsy, simple partial seizure was the most common type. The most commonly prescribed drug was sodium valproate for both generalized and partial seizures. Levetiracetam was found to be the preferred newer AED for management of generalized epilepsy. Similar prescribing pattern was seen in Asian countries where sodium valproate was the most preferred AED followed by levetiracetam and oxcarbazepine. Sodium valproate was also highly prescribed in European countries while levetiracetam and oxcarbazepine were underused. Two hundred and seven patients (60%) were managed on monotherapy.Conclusions Older generation AEDs are still used in majority of patients as mono and dual therapy. Among the newer generation AEDs, there is an increase in the utilization of levetiracetam. Prescription of AEDs in our study goes in line with Asian countries but differs with the European counterparts due to various reasons.

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“…Generally, monotherapy is the first line of treatment because it has few drug interactions and side effects, tolerability, increased compliance, and quality of life. [5][6][7][8][9]…”

Section: Introductionmentioning

confidence: 99%

Drug Utilization and Evaluation of Antiepileptic Drugs in a Tertiary Care Hospital

SK¹,

Durga²,

Sahithi³

et al. 2022

Ind. J. Pharm. Pract.

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Aim: Drug utilization and evaluation (DUE) study of antiepileptic drugs in a tertiary care hospital. Methods: A total of 110 case records of patients were included in a prospective observational study which was conducted for duration of 6 months. The prescription pattern was analyzed based on age, gender, route of administration, indication, duration of therapy, type of seizures, generation of Anti-Epileptic Drugs (AEDs), and rationality. Results: AEDs were prescribed more for patients between the ages of 51-60 years. The majority of patients receiving AEDs were males and AEDs were mostly used in the neurology department followed by neurosurgery and general medicine. Levetiracetam was prescribed most commonly as monotherapy. Lorazepam and midazolam were the most common add-on drugs. Gabapentin was mostly prescribed for severe neuropathic pain. The oral route was the common route of administration of AEDs. AEDs were highly prescribed for prophylaxis of seizures. Second-generation AEDs were highly used compared to other drugs. Conclusion: Second-generation AEDs were used as monotherapy and were found to be effective in reducing seizures and economically affordable for patients. As monotherapy, levetiracetam was the drug of choice followed by lorazepam.

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A Prospective Study of Drug Utilization Pattern of Anti-Epileptic Drugs and Their Adverse Effects in a Tertiary Care Hospital

Cited by 6 publications

References 9 publications

Adverse Drug Reactions of Anti-Epileptic Drugs in Pediatric Age Group in a Tertiary Care Teaching Hospital; A Cross-Sectional Study

Adverse Drug Reactions of Anti-Epileptic Drugs in Pediatric Age Group in a Tertiary Care Teaching Hospital; A Cross-Sectional Study

Evaluation and comparison of the utilization of anti‐epileptic drugs in Indian paediatric patients with global usage data

Drug Utilization and Evaluation of Antiepileptic Drugs in a Tertiary Care Hospital

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