A prospective study of endometriosis and risk of benign breast disease

Abstract

Purpose Given the altered hormonal and inflammatory environment of women with endometriosis, several studies have suggested a positive association between endometriosis and breast cancer, although findings have been mixed. This study investigates the relationship between endometriosis and benign breast disease (BBD), benign lesions that are associated with an increased risk of breast cancer. Methods Among women in the Nurses’ Health Study II followed from 1991–2003 (n=76,393), we investigated the association between laparoscopically confirmed endometriosis and biopsy confirmed BBD. Cox proportional hazard models, adjusted for a priori potential confounding factors, were used to calculate hazard ratios (HR) and 95% confidence intervals (CI). Across follow-up, 2,011 BBD biopsies were collected and centrally reviewed by study pathologists (non-proliferative = 675, proliferative =1,336). Effect modification by infertility history and use of screening mammography was investigated. Results Endometriosis was associated with a modest increased risk of biopsy confirmed BBD in crude and multivariable adjusted models (HR:1.20, 95% CI:1.00–1.43). When evaluating subtypes of BBD, we did not see different associations for nonproliferative or proliferative BBD lesions, as endometriosis was associated with a modest increased risk for both (HR nonproliferative:1.15, 95% CI:0.84–1.57; HR proliferative:1.22, 95% CI:0.98–1.52). The association between endometriosis and proliferative BBD appeared strongest among women who had ever experienced infertility (HR: 1.50, 95% CI:1.12–2.03; P-value, test for heterogeneity=0.05). Sensitivity analyses investigating screening behaviors between those with and without endometriosis did not significantly alter results. Conclusion Endometriosis was associated with a modest increased risk of both proliferative and non-proliferative BBD, although future work should replicate this novel finding.

Machine Learning Approach to find the relation between Endometriosis, benign breast disease, cystitis and non-toxic goiter

“…Recently, Farland et al . reported that endometriosis is associated with benign breast disease, which is similar to our results 15 . There are many hypotheses about the pathogenesis of endometriosis, but there is no question that endometriosis is an estrogen-dependent disease 1 .…”

Association between breast diseases and symptomatic uterine fibroids by using South Korean National Health Insurance database

“…Our study also presented that the risk of BBD was higher in women with endometriosis than in women without endometriosis, but the risk of CIS or BC was not. Endometriosis has been known to be associated with a modestly increased risk of both proliferative and nonproliferative BBD 44 . This finding is inconsistent with the majority of previous studies reporting an increased risk of BC in women with endometriosis.…”

Clinical and anamnestic risk factors for the development of external genital endometriosis in women of reproductive age

“…У обследованных нами пациенток основной группы выявлена статистически незначимо (p = 0,304) в 1,9 раза более высокая частота дисплазии молочных желез, что согласуется с данными литературы: у женщин с НГЭ обнаружено умеренное увеличение риска доброкачественных заболеваний молочных желез [30].…”