A Prospective Study of Lower Urinary Tract Symptoms and Erectile Dysfunction

Mondul, Alison M.; Rimm, Eric B.; Giovannucci, Edward; Glasser, Dale B.; Platz, Elizabeth A.

doi:10.1016/j.juro.2008.01.150

Cited by 33 publications

(19 citation statements)

References 20 publications

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“…The IIEF-5 and IPSS scores were correlated (p<0.001) to each other. This was similar to the findings of the study done by Mondul et al,20 who claimed that lower urinary tract symptoms referred to by the IPSS is a relevant factor in ED.…”

Section: Discussionsupporting

confidence: 92%

Testosterone Deficiency with Erectile Dysfunction in Mongolian Men

Naidan¹,

Rivaad

Muukhai

et al. 2013

World J Mens Health

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PurposeTo detect the testosterone deficiency syndrome in Mongolian men over 40 years old with erectile dysfunction (ED).Materials and MethodsTotal of 309 males over 40 years of age who received medical care at the ADAM Urology and Andrology Clinic from 2010 to 2011 were included in this study. An approval from the Ethics Committee of the Ministry of Health of Mongolia was obtained, and each study participant signed a consent form at the beginning of the study. The participants were assigned to either an ED group or a control group, depending on the results of the international index of erectile function (IIEF)-5 questionnaire. The ED group was further divided into three groups (moderate, severe, and very severe) based on the level of ED. The total testosterone (TT) levels were determined in the blood serum using a competitive enzyme-linked immunesorbent assay (ELISA) analytical system UBI Magiwel™ Testosterone Quantitative test, and free testosterone (FT) calculated as described by the Vermeulen calculation. Test samples were collected between 8:00 and 11:00 am in the mornings and testosterone deficiency syndrome was diagnosed based on the International Society for the Study of the Aging Male guidelines, particularly, if TT was ≤3.46 ng/ml or free testosterone FT was ≤0.072 ng/ml.ResultsED of moderate, severe, and very severe levels was diagnosed in 199 (64.41%) out of 309 participants. There was an inverse relationship between the main IIEF-5 score and age (r=-0.380, p<0.01). The average TT was 5.75±2.316 ng/ml and FT was 0.091±0.0084 ng/ml. Compared to the ED group, the control group had a higher TT level: 5.6440±1.177 ng/ml and 5.812±2.316 ng/ml, respectively. In the control group, the FT level was 0.061±0.0084 ng/ml, whereas it was 0.041±0.0076 ng/ml in the ED group.ConclusionsOur study showed that most of the aging males who came to the clinic had moderate to very severe ED (64.55%). The levels of TT (5.644±1.177 ng/ml) and FT (0.041±0.0036 ng/ml) were significantly lower in ED patients (p<0.05). The testosterone deficiency syndrome was detected in 24.27% of the ED group.

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Section: Discussionsupporting

confidence: 92%

Testosterone Deficiency with Erectile Dysfunction in Mongolian Men

Naidan¹,

Rivaad

Muukhai

et al. 2013

World J Mens Health

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“…The risk of ED increased with rising LUTS severity with stronger correlation in younger than in older men. 8 This correlation was proved worldwide as evidenced by the results of the Asian Survey of Aging Males study. This survey was carried out in Asian men aged 50-80 years from five Asian countries.…”

Section: Luts and Ed: Clinical And Epidemiological Correlationsmentioning

confidence: 89%

Association of lower urinary tract symptoms and erectile dysfunction: pathophysiological aspects and implications for clinical management

2011

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There is strong evidence from multiple epidemological studies that lower urinary tract symptoms (LUTS) and erectile dysfunction (ED) are correlated, independent of age or comorbidities as diabetes or hypertension. Although a direct causal relationship is not established yet, four pathophysio logical mechanisms can explain the relationship. These include alteration in nitric oxide bioavailability, a1-adrenergic receptor hyperactivity, pelvic atherosclerosis and sex hormones. This association has different clinical implications on the management of both disorders. Men seeking care for one condition should always be screened for complaints of the other condition. Sexual function should be assessed and discussed with the patient when choosing the appropriate management strategy for LUTS, as well as when evaluating the patient's response to treatment. Multiple large clinical trials have shown an improvement in LUTS after phosphodiesterase-5 (PDE5)-inhibitor treatment. PDE5 inhibitors show promise as a future treatment for LUTS, either in conjunction with existing therapies or as a primary treatment. There may be a potential therapeutic role for testosterone in LUTS treatment in cases of testosterone deficiency that needs to be investigated. Much further investigation is required, but it is evident that the association between LUTS and ED is fundamental for future therapies and possible preventative strategies.

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“…Male LUTS and sexual dysfunction are conditions encountered on a daily basis in urology practice. A great deal of epidemiologic and clinical research has shown that LUTS and sexual dysfunction are strongly linked (Grade B) [77–86]. Multidisciplinary human study is warranted on the basis of the possible common pathogenesis for LUTS and sexual dysfunction (Grade C) [87].…”

Section: Sexual Dysfunction Associated With Lower Urinary Tract Symptmentioning

confidence: 99%

Sexual Function in Chronic Illness

Basson

Rees

Wang

et al. 2010

The Journal of Sexual Medicine

201

135

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Introduction Direct and indirect effects of chronic disease on sexual health are frequent and complex, but guidelines for their optimal management are lacking. With improved surgical and medical treatment of the underlying disease, the numbers of men and women needing assessment and management of associated sexual dysfunction are increasing. Aim To provide recommendations/guidelines for the clinical management of sexual dysfunction within the context of chronic illness. Methods An international consultation in collaboration with the major sexual medicine associations assembled 186 multidisciplinary experts from 33 countries into 25 committees. Nine experts from four countries compiled the recommendations of sexual dysfunction in chronic illness and cancer with four focusing on neurological, renal, and psychiatric disease and lower urinary tract symptoms (LUTS). Searches were conducted using Medline, Embase, Lilacs, and Pubmed databases. Main Outcome Measures Expert opinion was based on grading of evidence-based medical literature, widespread internal committee discussion, public presentation, and debate. Results Some conclusions concerning prevalence and pathophysiology of sexual dysfunction in the context of neurological disorders, end-stage renal failure, LUTS, and psychiatric disease were made. Optimal assessment of the multiple factors affecting sexuality when one or both partners are chronically ill is outlined. Evidence-based recommendations for management are presented. Comorbid depression is frequent and independently determines prevalence of sexual dysfunction in many conditions. Conclusions There is need for more research and scientific reporting on prevalence, pathophysiology, and optimal treatment of sexual dysfunction associated with chronic illness. Screening for and managing comorbid depression is strongly recommended.

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A Prospective Study of Lower Urinary Tract Symptoms and Erectile Dysfunction

Cited by 33 publications

References 20 publications

Testosterone Deficiency with Erectile Dysfunction in Mongolian Men

Testosterone Deficiency with Erectile Dysfunction in Mongolian Men

Association of lower urinary tract symptoms and erectile dysfunction: pathophysiological aspects and implications for clinical management

Sexual Function in Chronic Illness

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