A prospective study of maternal and fetal outcome in acute Lassa fever infection during pregnancy

Price, ME; Fisher-Hoch, SP; Craven, RB; McCormick, Joseph B.

doi:10.1016/0020-7292(89)90756-x

Cited by 41 publications

(57 citation statements)

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“…There is growing evidence suggesting that the placental response to virus is directly responsible for disease severity. For example, pregnant women infected with Lassa fever had higher mortality rates than did nonpregnant women with the infection (110). The Lassa virus replicates at very high levels in the placenta (111), and the risk of maternal death increases with the length of gestation (110) and the size of the placenta.…”

Section: Viral Infection and Ptb: In Utero Or Systemic Infectionmentioning

confidence: 99%

“…The Lassa virus replicates at very high levels in the placenta (111), and the risk of maternal death increases with the length of gestation (110) and the size of the placenta. Furthermore, evacuation of the uterus significantly improves the mother's chances of survival (110). Since the placenta regulates the maternal immune system and can itself respond to pathogens, it is probably an important mediator of the maternal response to viral infection, regardless of whether the placenta is directly infected (112).…”

Section: Viral Infection and Ptb: In Utero Or Systemic Infectionmentioning

confidence: 99%

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Risks associated with viral infections during pregnancy

Racicot¹,

Mor

2017

Journal of Clinical Investigation

248

204

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Section: Viral Infection and Ptb: In Utero Or Systemic Infectionmentioning

confidence: 99%

Section: Viral Infection and Ptb: In Utero Or Systemic Infectionmentioning

confidence: 99%

Risks associated with viral infections during pregnancy

Racicot¹,

Mor

2017

Journal of Clinical Investigation

248

204

View full text Add to dashboard Cite

“…Among female Lassa Fever patients of childbearing years admitted to a hospital in Sierra Leone, death was significantly higher for pregnant women (25%) than non--pregnant women (13%) [88]. Tellingly, symptoms improved with delivery [88].…”

Section: Infectious Disease and Selection During Pregnancymentioning

confidence: 96%

“…Tellingly, symptoms improved with delivery [88]. The Ebola virus killed more pregnant patients (95.5%) than the population average (77%) during an outbreak in the DRC [89].…”

Section: Infectious Disease and Selection During Pregnancymentioning

confidence: 99%

Many ways to die, one way to arrive: how selection acts through pregnancy

2013

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“…Infection during pregnancy can lead to fetal death (because the virus has high affinity for placenta and other highly vascularized tissues), abortion, including loss of newborn (in 90% of cases) or maternal death. [3,26,27] Serious congenital defects or abnormalies are common sequelae in children born with Lassa fever infection [27,28].…”

Section: Epidemiological Trend Of Lassa Fevermentioning

confidence: 99%

Review of Lassa fever, an emerging old world haemorrhagic viral disease in sub-Saharan Africa

Azeez-Akande¹

2016

Af J Clin Exp Micro

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Lassa fever is an acute immunosuppressive illness of increasing public health concern causing severe morbidity and significant mortality (Case fatality rate (CFR) ≥ 50%) especially in epidemic cases. Although Lassa fever has emerged (following its first detection (1969) in Lassa town, Nigeria) as one of the most prevalent and debilitating viral haemorrhagic fevers endemic in West Africa region (Nigeria inclusive), yet, the control/prevention of the regular outbreak of the disease has become an herculean task in the areas affected; there is inadequate healthcare facility (including Laboratory/diagnostic and care centres), poor socioeconomic environment, lack of awareness among the populace and presence of favourable ecologic niche for the survival and propagation of the natural host and reservoir mouse (Mastomys natalensis) of Lassa virus . Lassa fever is mainly transmitted by contact with excretions and secretions of infected rats via foods and water as well as exposure to other contaminated items. Lassa virus is a member of an Old World Arenariruses, of family Arenaviridae. It is an enveloped, single-stranded (SS) bisegmented RNA virus with ability to replicate very rapidly. It consists of 4 lineages; 3 members are identified as ancenstral strains found in Nigeria, while the fourth is domiciled in other West Africa Countries. Lassa virus infects almost every tissue in human body resulting in multisystemic dysfunction. The incubation period is generally between 6 to 21 days resulting in 3 stages of clinical manifestation viz: Acute phase characterized by flu-like, non-specific illness; haemorrhagic phase accompanied with gastrointestinal symptoms and cardiovascular/neurologic complications. Currently, there is no clinically certified Lassa fever vaccine thus complicating deterrent or preventive measures. Hence, there is need for intensification of educational programs for the populace on the useful control measures against Lassa fever. The stakeholders need to prioritize intervention and support program and also speed up the processes leading to the production of effective vaccine to limit the menace of Lassa fever outbreak and associated morbidity, fatality and high socio-economic cost.

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A prospective study of maternal and fetal outcome in acute Lassa fever infection during pregnancy

Cited by 41 publications

References 0 publications

Risks associated with viral infections during pregnancy

Risks associated with viral infections during pregnancy

Many ways to die, one way to arrive: how selection acts through pregnancy

Review of Lassa fever, an emerging old world haemorrhagic viral disease in sub-Saharan Africa

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