2014
DOI: 10.1111/dsu.12415
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A Prospective Study of Non-Surgical Primary Rhinoplasty Using a Polymethylmethacrylate Injectable Implant

Abstract: Filler rhinoplasty using a PMMA-based injectable filler is safe and effective. This is the first study documenting the use of PMMA for this indication. Longer-term follow-up is needed to demonstrate persistence of improvement.

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Cited by 37 publications
(20 citation statements)
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“…Most practitioners agree that biodegradable fillers should be used in preference to permanent fillers for safety reasons, although some authors still favor permanent fillers. 4 In our study we assessed safety of the procedure, as there are potential disastrous complications that can occur, such as amaurosis after injection of fillers, fat, 5 or local anesthesia, 6 probably due to accidental intra-arterial injection with subsequent occlusion of the central retinal artery or its branches. Similar complications have been reported following septoplasty and rhinoplasty.…”
Section: Discussionmentioning
confidence: 99%
“…Most practitioners agree that biodegradable fillers should be used in preference to permanent fillers for safety reasons, although some authors still favor permanent fillers. 4 In our study we assessed safety of the procedure, as there are potential disastrous complications that can occur, such as amaurosis after injection of fillers, fat, 5 or local anesthesia, 6 probably due to accidental intra-arterial injection with subsequent occlusion of the central retinal artery or its branches. Similar complications have been reported following septoplasty and rhinoplasty.…”
Section: Discussionmentioning
confidence: 99%
“…35 It is currently FDA approved for the correction of nasolabial folds and moderate-to-severe atrophic facial acne scars, 35,36 but has been used successfully to correct malar atrophy and infraorbital rhytides and for nonsurgical rhinoplasty. [37][38][39][40][41] While rheology has been useful in evaluating the clinical performance of HA fillers and to some extent, CaHA, it does not appear to be useful in predicting the clinical effects of PMMA and limited studies have been performed evaluating the rheologic properties of PMMA. The volumizing effects of PMMA can be explained by its ability to stimulate collagen synthesis, similar to that of CaHA and PLLA.…”
Section: Polymethylmethacrylate Microspheresmentioning
confidence: 99%
“…This year I published a prospective, blinded study on the safety and efficacy of injecting methyl methacrylate (Artefill, Suneva, Santa Barbara, CA) to correct nasal contour deficiencies [21]. Artefill is a third-generation methyl methacrylate filler in a collagen carrier that was FDA approved in 2006 for nasolabial fold correction.…”
Section: Historymentioning
confidence: 99%