A prospective study of novel mathematical analysis of the contrast-enhanced computed tomography vs renal scintigraphy in renal function evaluation

Fiev, D.; Proskura, A.; Khokhlachev, S.B.; Taratkin, Mark; Borisov, Vladimir; Chernenkiy, Mikhail; Gabdulina, Svetlana; Leonard, Stephen Pax; Alyaev, Yuriy; Rivas, Juan Gómez; Enikeev, Dmitry; Glybochko, Petr

doi:10.1016/j.ejrad.2020.109169

Cited by 4 publications

(5 citation statements)

References 18 publications

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“…Всем пациентам на дооперационном этапе проводилось полное клинико-лабораторно-инструментальное обследование, необходимое для проведения запланированной НСО по поводу одностороннего образования паренхимы почки. На основании данных МСКТ почек с контрастированием больным выполнялось предоперационное виртуальное планирование предстоящей НСО [35][36][37]. Кроме того, предварительное трехмерное (3D) моделирование использовалось в дальнейшем для оценки раздельного объема функционирующей паренхимы (ОФП) и раздельной функции почек, СКФ и перфузии почек с помощью математического анализа полученных 3D-данных.…”

Section: оригинальная статья / Original Reportunclassified

“…Динамика показателей раздельной почечной функции (3D-СКФ, 3D-перфузия, 3D-ОФП каждой почки, суммарный ОФП почек) оценивалась в сравнении между пораженной и непораженной опухолью почки. Необходимо отметить, что если такие показатели, как перфузия, суммарный и раздельный ОФП, являлись показателями, относящимися к работе всей почки в целом, то 3D-СКФ -расчетный показатель, отражающий работу 1 см 3 паренхимы почки [35,38].…”

Section: оригинальная статья / Original Reportunclassified

“…На данную методику получен патент на изобретение «Способ исследования функции почек при мультиспиральной компьютерной томографии» (№ RU2673384C1 от 19.06.2017). В соот-ветствии с результатами проведенного исследования при использовании метода математического анализа данных КТ результаты оценки функции почки были сопоставимы с таковыми при динамической нефросцинтиграфии (р <0,001) [35], что говорит о безопасности и эффективности данного метода, а также о возможности его внедрения в практику.…”

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Assessment of the kidney functional state prior and after partial nephrectomy for a unilateral tumor using mathematical processing of computed tomography data with contrast enhancement

Proskura,

Alyaev,

Borisov

et al. 2023

Androl. genit. hir.

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Background. According to the contemporary data available contrast-enhanced computed tomography can be used to assess total and split kidney function. The Urology Clinic of the I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University) utilizes mathematical processing of computed tomography data for the assessment of split kidney function.Aim. To evaluate the effect of main renal artery clamping (warm ischemia time) during partial nephrectomy for a unilateral tumor on the kidney function.Materials and methods. 33 patients of both sexes who underwent partial nephrectomy for unilateral kidney tumor were enrolled in the study. Prior to and 3–6 months after the surgery, 3D glomerular filtration rate (GFR), 3D perfusion, 3D volume of the renal parenchyma were evaluated by mathematical processing of computed tomography data with contrast enhancement. As well as that the dynamics of the total GFR (CKD-EPI equation) and total volume of the kidneys were assessed.Results. No significant changes were registered for both general functional renal parameters (creatinine level, total GFR, total volume of functioning renal parenchyma) and split 3D GFR. There were significant differences in 3D perfusion and kidney parenchyma volume prior and after partial nephrectomy.Conclusion. The results of the research highlight good reserve capacity the kidneys after partial nephrectomy with main renal artery clamping. The evidence that the non-operated kidney takes over the function of the resected kidney is based on the fact that there is an increase in its perfusion and volume of the kidney in the postoperative period. This state can also be regarded as a redistribution of functional loads between the kidneys, which is an adaptive mechanism in the postoperative period.

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Section: оригинальная статья / Original Reportunclassified

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Assessment of the kidney functional state prior and after partial nephrectomy for a unilateral tumor using mathematical processing of computed tomography data with contrast enhancement

Proskura,

Alyaev,

Borisov

et al. 2023

Androl. genit. hir.

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“…Для оценки СКФ был проведен математический анализ данных КТ почек с контрастированием. Разработанная методика позволяет получить данные о почечном плазмотоке и перфузии, удельной СКФ (референсные значения СКФ: 0,55 ± 0,3 % КВ в секунду) [19]. Исследование подразумевает оценку распределения КВ в объемах почек по отдельности.…”

Section: материалы и методыunclassified

“…Мы предложили метод оценки раздельной функции почек с помощью КТ (патент на изобретение № 2673384). В отличие от сцинтиграфии почек предлагаемый метод позволяет оценить многие внутрипочечные процессы, в частности скорость клубочковой фильтрации (СКФ), основанную на численном анализе данных КТ с контрастным усилением [19]. Мы использовали данную инновационную методику в оценке СКФ [20] для каждой почки отдельно, а также изучили структуру почечной паренхимы в ее трехмерной модели у пациентов с мочекаменной болезнью (МКБ).…”

Section: Introductionunclassified

Mathematical postprocessing analysis of contrast-enhanced computed tomography data of the kidneys in evaluation of split renal function in patients with kidney stone disease

Fiev

Khokhlachev

Borisov

et al. 2021

Androl. genit. hir.

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Introduction. An original research work was performed to assess split kidney function by glomerular filtration rate (GFR) with mathematical analysis of the kidneys computed tomography (CT) data in patients with kidney stone disease (KSD). Objective was to evaluate the GFR and the parenchyma structure of each kidney and identify the possible patterns of contrast medium intrarenal transport with mathematical analysis of the kidneys CT data in patients with KSD.Materials and methods. Data of 27 patients of both genders with KSD were retrospectively analyzed. To evaluate GFR separately for each kidney we analyzed the data of contrast-enhanced CT (GFR reference values are 0.55 % of contrast medium per second). Inclusion criteria are as follows: 1) newly diagnosed SKD; 2) stone size ≤1,5-2,0 cm, no obstruction of the urine flow registered; 3) no kidney or upper urinary tract surgical history; 4) age - ≤45 years; 5) no severe chronic diseases. All of these allowed to minimize influence of any other disorders on split renal function except for SKD and conduct per se research.Results. The mathematic analysis of the contrast-enhanced CT data revealed GFR changes in 26 (96.3 %) out of 27 patients. Hyperfiltration was found in 12 (44.4 %) patients: right kidney GFR - 0.6-0.77 %, mean value - 0.65 %; left kidney GFR - 0.59-0.79 %, mean value - 0.67 %. Hypofiltration was found in 13 (48.1 %) patients: right kidney GFR - 0.2-0.54 %, mean value - 0.37 %; left kidney GFR - 0.2-0.53 %, mean value - 0.4 %. The GFR values significantly differed between the groups both for the right (p = 0.000014) and left (p = 0.000045) kidneys. We found no significant age-related difference between the groups (p = 0.895). As well as that no significant differences in Resistance Index both in magistral (right kidney: p = 0.221; left kidney: p = 0.850) and segmental (right kidney: p = 0.306; left kidney: p = 0.957) arteries between the groups with hyperfiltration and hypofiltration were observed. One patient demonstrated no changes in GFR, and the other one had hyperfiltration (0,62 %) in one kidney and hypofiltration (0,48 %) in another.Conclusion. Most of the patients (92.6 %) with SKD demonstrate GFR changes (either hyperfiltration or hypofiltration) that may indicate the disturbed intrarenal blood and urine flow through the kidney.

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A fully automatic deep learning-based method for segmenting regions of interest and predicting renal function in pediatric dynamic renal scintigraphy

Ji,

Zhu,

Gou

et al. 2024

Ann Nucl Med

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A prospective study of novel mathematical analysis of the contrast-enhanced computed tomography vs renal scintigraphy in renal function evaluation

Cited by 4 publications

References 18 publications

Assessment of the kidney functional state prior and after partial nephrectomy for a unilateral tumor using mathematical processing of computed tomography data with contrast enhancement

Assessment of the kidney functional state prior and after partial nephrectomy for a unilateral tumor using mathematical processing of computed tomography data with contrast enhancement

Mathematical postprocessing analysis of contrast-enhanced computed tomography data of the kidneys in evaluation of split renal function in patients with kidney stone disease

A fully automatic deep learning-based method for segmenting regions of interest and predicting renal function in pediatric dynamic renal scintigraphy

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