A prospective study of the incidence of deep‐vein thrombosis within a defined urban population

Abstract

In a prospective study all positive phlebographies within the well-defined population of the city of Malmö, Sweden, during 1987 were studied in order to determine the incidence of deep venous thrombosis (DVT). Epidemiological data were analysed for the detection of patient groups at increased risk of DVT. The incidence was found to be equal for both sexes, i.e. 1.6 per 1000 inhabitants a year. Risk factors were found to be in accordance with earlier studies. The median age for men was 66 years, compared to 72 years for women. At diagnosis of DVT, 19% of subjects had a known malignancy and within 1 year 5% (19 cases) developed a new malignancy. Of the men, 29% had postoperative or post-traumatic (fracture) DVT, compared to 46% of the women. Fewer patients with DVT than expected (39%) belonged to blood group 0 (31%) (P less than 0.005). Pulmonary embolism (PE) was clinically suspected in only 5% of cases, and diagnosis was verified scintigraphically in 2% of cases. None of these died of PE, but of 6 patients who were found to have PE at autopsy, four died about 4 weeks after the DVT was diagnosed.

Associations of Trauma Exposure and Posttraumatic Stress Symptoms With Venous Thromboembolism Over 22 Years in Women

“…Furthermore, studying the link between PTSD symptoms and VTE specifically in a sample of younger and middle‐aged women has particular relevance for understanding VTE risk in women. Even though the overall rate of first VTE is similar in men and women,4 incidence rates are higher in women of childbearing age than in men of the same age 4, 5. This difference in incidence rate likely reflects, in part, VTE due to pregnancy and/or oral contraceptive use during childbearing years.…”

“…Female‐specific risk factors for VTE related to reproductive hormone exposure (eg, due to contraceptive therapy, pregnancy, and hormone therapy [HT]) have been documented,3 and VTE is a leading cause of mortality among pregnant and recently postpartum women in the United States 2. Additionally, VTE incidence rates are higher in women of childbearing age than in men of the same age,4, 5 likely reflecting VTE induced by pregnancy and/or oral contraceptive use during childbearing years. Given the disease burden and highly recurrent nature of VTE—a largely preventable condition—greater insight into factors that may increase risk or promote prevention, particularly in women, is a significant public health priority 2, 3.…”

Is polycystic ovary syndrome another risk factor for venous thromboembolism? United States, 2003–2008

“…[4][5][6][7] These incident estimates, however, might not represent the entire population because VTE incidence differs by age and race, and slightly by sex. VTE is a multifactorial disease with both inherited and acquired risk factors.…”

“…VTE is a multifactorial disease with both inherited and acquired risk factors. In 26-47% of first-time VTE cases, the etiology is unknown 4,5,8 ; a possible predisposing condition not yet assessed is polycystic ovary syndrome (PCOS).PCOS is the most common endocrine disorder affecting women of reproductive age. Estimates of its prevalence vary and range from 4-6%.…”

Does supervised exercise after deep venous thrombosis improve recanalization of occluded vein segments? A randomized study

“…Deep venous thrombosis (DVT) is a common disease occuring in approximately 1-2 cases per 1.000 individuals yearly [1,2]. In spite of this high frequency surprisingly little is known about the positive and/or negative effects of exercise in patients with DVT.…”