A Prospective Study of the Effects of Sex Hormones on Lung Function and Inflammation in Women with Cystic Fibrosis

Holtrop, Melanie; Heltshe, Sonya L.; Shabanova, Veronika; Keller, Ashley; Schumacher, Lauren; Fernandez, Lynn; Jain, Raksha

doi:10.1513/annalsats.202008-1064oc

Cited by 32 publications

(18 citation statements)

References 39 publications

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“…Inflammatory biomarkers and lung function are thus associated with hormonal cycling. In a prospective study, Holtrop et al followed 23 women with CF who were not taking hormonal contraceptives (57). At the time of estrogen peak (ovulation), there was a significant increase in pro-inflammatory cytokines in sputum (neutrophil elastase) and a decrease in lung function.…”

Section: Microbiome Hormones and Immune System: A Balanced Trianglementioning

confidence: 99%

The Human Microbiome, an Emerging Key-Player in the Sex Gap in Respiratory Diseases

2021

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The sex gap is well-documented in respiratory diseases such as cystic fibrosis and chronic obstructive pulmonary disease. While the differences between males and females in prevalence, severity and prognosis are well-established, the pathophysiology of the sex difference has been poorly characterized to date. Over the past 10 years, metagenomics-based studies have revealed the presence of a resident microbiome in the respiratory tract and its central role in respiratory disease. The lung microbiome is associated with host immune response and health outcomes in both animal models and patient cohorts. The study of the lung microbiome is therefore an interesting new avenue to explore in order to understand the sex gap observed in respiratory diseases. Another important parameter to consider is the gut-lung axis, since the gut microbiome plays a crucial role in distant immune modulation in respiratory diseases, and an intestinal “microgenderome” has been reported: i.e., sexual dimorphism in the gut microbiome. The microgenderome provides new pathophysiological clues, as it defines the interactions between microbiome, sex hormones, immunity and disease susceptibility. As research on the microbiome is increasing in volume and scope, the objective of this review was to describe the state-of-the-art on the sex gap in respiratory medicine (acute pulmonary infection and chronic lung disease) in the light of the microbiome, including evidence of local (lung) or distant (gut) contributions to the pathophysiology of these diseases.

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Section: Microbiome Hormones and Immune System: A Balanced Trianglementioning

confidence: 99%

The Human Microbiome, an Emerging Key-Player in the Sex Gap in Respiratory Diseases

2021

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“…On the other hand, studies have shown that following pro-inflammatory diets raises the levels of many inflammatory markers, including; Tumor necrosis factor alpha (TNFα), high-sensitivity C-reactive protein (hs-CRP), Interleukin1beta (IL-1β), Interleukin 6 (IL-6), Interleukin 10 (IL-10), in obese or chronically ill people, especially in women, which in turn has led to the spread of obesity in these people [ 13 , 20 , 21 ]. Due to the prevalence of obesity, abdominal obesity and malnutrition in developing societies, especially among women, as well as the limitations of studies conducted on this sensitive group of society [ 22 – 24 ] and also the greater likelihood of the spread of inflammatory conditions, such as viral [ 25 ] and respiratory inflammatory diseases [ 26 ] in women compared to men and also according to our investigations, the majority of studies on the relationship between DII and obesity and many other diseases are more in women compared to men [ 27 – 29 ]. In this regard, a 20-year cohort study was performed on 70,991 women with diabetes and the effect BMI mediator was also examined in this study, the results of which showed a direct relationship between the incidence of diabetes and DII through BMI [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

Dietary inflammatory index (DII) may be associated with hypertriglyceridemia waist circumference phenotype in overweight and obese Iranian women: a cross sectional study

et al. 2021

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Objective Recent studies have shown that increased dietary inflammatory index (DII) score or consumption of pro-inflammatory foods can lead to increased waist circumference (WC) as well as triglyceride (TG) concentrations in obese people. The purpose of this study is to examine the association between DII and hypertriglyceridemic waist circumference phenotype (HTGWCP) in women with overweight and obesity. Results There was a positive significant correlation between DII and HTGWCPs. In other words, with an increase in DII score or higher consumption of pro-inflammatory foods, the odds of having abnormal phenotypes including; enlarged waist normal TG (EWNT) (OR = 2.85, 95% CI 1.02 to 7.98, P for trend = 0.04), normal waist enlarged TG (NWET) (OR = 5.85, 95% CI 1.1 to 31.11, P for trend = 0.03) and enlarged waist enlarged TG (EWET) (OR = 3.13, 95% CI 0.95 to 10.27, P for trend = 0.05) increase compared to normal waist normal TG (NWNT) phenotype. In conclusion; increasing DII scores can increase abnormal phenotypes and therefore may increase WC and TG levels in overweight and obese women.

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“…Previous studies of the role of estrogen supplementation for women with CF have focused on outcomes of inflammation [9] , [17] , [18] , [19] , pulmonary function [18] , [19] , nutrition [19] , and bone mineral density [20] , [21] . Oral contraceptive use by women with CF has been associated with decreased frequency of acute pulmonary exacerbations, decreased bone mineral density, similar declines in FEV1 and similar BMI compared to women with CF not using oral contraception [17] , [18] , [19] , [20] , [21] .…”

Section: Discussionmentioning

confidence: 99%

“…Women with CF have been shown to have low estrogen levels [7] and delayed puberty indicating hypogonadism compared to age-matched controls without CF [8] . The association of estrogen supplementation and quality of life was recently explored in 12 women with CF who were started on estrogen supplementation for two months by Holtrop and colleagues using the CF questionnaire-revised (CFQ-R) [9] . The CFQ-R is a CF-disease specific health-related quality of life instrument that assesses quality of life across 12 domains.…”

Section: Introductionmentioning

confidence: 99%

Use of estrogen supplementation is associated with higher quality of life scores in women with cystic fibrosis

Arora

Sueblinvong

et al. 2022

Journal of Clinical & Translational Endocrinology

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A Prospective Study of the Effects of Sex Hormones on Lung Function and Inflammation in Women with Cystic Fibrosis

Cited by 32 publications

References 39 publications

The Human Microbiome, an Emerging Key-Player in the Sex Gap in Respiratory Diseases

The Human Microbiome, an Emerging Key-Player in the Sex Gap in Respiratory Diseases

Dietary inflammatory index (DII) may be associated with hypertriglyceridemia waist circumference phenotype in overweight and obese Iranian women: a cross sectional study

Use of estrogen supplementation is associated with higher quality of life scores in women with cystic fibrosis

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