A Prospective Study on Complement Activation Distinguishes Focal Segmental Glomerulosclerosis from Minimal Change Disease

The Lectin Pathway–A Dominant Pattern of the Complement System Activation in Primary Focal Segmental Glomerulosclerosis?

“…We read with a big interest article by Cambier et al. 1 reporting significantly elevated urine levels of C5b-C9 and C5a in individuals with focal segmental glomerulosclerosis (FSGS), indicating the role of the complement system activation in disease pathogenesis. We can not only confirm the role of complement system activation in pathogenesis of primary FSGS, but also show prognostic significance of C4d, long-term tissue “fingerprint“ of complement activation, and the role of lectin pathway activation.…”