A prospective study on radiation-induced changes in hearing function

Herrmann, Franziska Marie; Dörr, Wolfgang; Müller, Rainer; Herrmann, Thomas

doi:10.1016/j.ijrobp.2006.03.032

Cited by 38 publications

(33 citation statements)

References 20 publications

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“…Those children received 5000 cGy of total dose, resulting in 1000 cGy in the auditory system. Some authors mentioned that 4000 cGy would be of risk to the auditory system [28,29], while others report that low doses of 20-25 Gy may induce signifi cant changes in hearing thresholds (15 dB) with large confidence limits [30]. Nevertheless, a dose-dependent relation risk for high-frequency hearing loss has also been reported [31].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of ototoxicity in children treated for retinoblastoma: preliminary results of a systematic audiological evaluation

et al. 2011

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Section: Discussionmentioning

confidence: 99%

Evaluation of ototoxicity in children treated for retinoblastoma: preliminary results of a systematic audiological evaluation

et al. 2011

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“…In this study, patients with variety of HNCs were included (Brain tumor, tongue, nasopharynx, parathyroid, face, jaw, tonsil, and orbital). Although in some studies the effect of radiation on threshold of hearing in patients with different HN tumors were evaluated (14, 22,23), in most of the studies, only patients with nasopharynx carcinoma were investigated (8,10,(24)(25)(26)(27)(28).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Radiation Therapy on Hearing Loss in Patients with Head and Neck Cancer

et al. 2018

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Background: Radiotherapy is one of the important components of head and neck cancer (HNC) treatment. This treatment method may cause a variety of side effects like oral problems, swelling, and hearing loss. Objectives: In this study, the effect of radiotherapy on hearing loss in patients with HNC was investigated. Methods: In this prospective cohort research, patients with head and neck cancer referring to the Shohadaye Tajrish Hospital during 2014 to 2015 were investigated. All of these patients were candidate for radiotherapy as the main treatment. The radiotherapy of patients was done by 3D-computer based treatment planning system, using their CT scan. In order to oncologic assessment, preand post-radiotherapy audiologic evaluations were done. The common toxicity criteria for the adverse events (CTCAE V4.02) of the National Cancer Institute (NCI) were used for ototoxicity. A bivariate latent variable model was used to assess the effect of received dose on the severity of hearing loss. Results: In this study, 66 patients with HNC were investigated. Among them, 46 patients (70%) were male. The mean (SD) age of patients was 45.33 (15.11). The incidence rate of hearing loss in these patients was about 18%. The result of statistical modeling showed a positive relationship between severity of HL and received dose of radiation (P < 0.001). Conclusions:In general, the findings of this study showed a direct relationship between radiation dose received by the ears and severity of hearing loss in patients with HNC. In this context, paying more attention to dose-prescription limits and standards for assessing radiation therapy associated ototoxicity are strictly recommended.

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“…Majority of the studies on SNHL in such patients were published on nasopharyngeal carcinoma patients receiving radiation [3][4][5][6][7][8] except few studies [9][10][11]. However, there is still uncertainty prevailing regarding the pattern of hearing loss, the frequencies affected and the dose of chemoradation effects on the hearing.…”

Section: Discussionmentioning

confidence: 99%

Effects of Chemoradiation on Hearing in Patients with Head and Neck Malignancies: Experience at a Tertiary Referral Care Hospital

Jain¹,

Banerjee²,

Dandinarasaiah

2016

Indian J Otolaryngol Head Neck Surg

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Hearing loss as a side effect in patients with head and neck malignancies with chemoradiation is frequently ignored. Its effects on auditory functions are less studied and there are studies done on animals which are less reliable. The present study was undertaken to identify the type of hearing loss and also to quantify the degree of hearing loss in these patients. A prospective, descriptive study was undertaken in histologically proven head and neck cancer patients treated with cobalt 60 teletherapy who received a dose of 60-66 Grays (Gy) over a period of 6-7 weeks with concurrent Cisplatin 30 mg/m 2 once weekly for 6 weeks. The study included 40 patients (80 ears) undergoing chemoradiation. A baseline pure tone audiometry and impedance audiometry was performed in all the cases prior to the therapy and the same was repeated immediately after the completion of treatment, at 8 and 16 weeks. The changes in pure tone level thresholds and impedance from baseline were correlated with the dose of radiation and chemotherapy. Sensori neural hearing loss (SNHL) and conductive hearing loss was observed in 82.5 and 17.5 % respectively. At the end of 16 weeks, SNHL was found in 27.5, 72.5 and 82.5 % at 2, 4 and 8 kHz respectively. In addition, Eustachian tube dysfunction and Otitis media with effusion was observed in 10 and 7.5 % of patients respectively which lead to conductive hearing loss. Further, it was noted that SNHL in patients with high risk site malignancy (81.8 %) was alarmingly higher compared with low risk site malignancy (18.1 %). The hearing loss at 62, 64 and 66 Gy in comparison to 60 Gy was statistically significant. Hearing loss, specially SNHL was the predominant finding in our study with [80 % of patients showing the inner ear damage due to irradiation of head and neck malignancies. Although, all the frequencies like 2, 4 and 8 kHz were significantly affected, SNHL was more marked in the latter two frequencies. Nearly, 90 % of the patients who had SNHL belonged to high risk site category of head and neck malignancies. Increasing the radiation dosage was directly proportional to the degree of hearing loss with the dose more than 60 Gy causing significant injury to the middle and inner ear.

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A prospective study on radiation-induced changes in hearing function

Cited by 38 publications

References 20 publications

Evaluation of ototoxicity in children treated for retinoblastoma: preliminary results of a systematic audiological evaluation

Evaluation of ototoxicity in children treated for retinoblastoma: preliminary results of a systematic audiological evaluation

The Effect of Radiation Therapy on Hearing Loss in Patients with Head and Neck Cancer

Effects of Chemoradiation on Hearing in Patients with Head and Neck Malignancies: Experience at a Tertiary Referral Care Hospital

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