A prospective study on second-generation colon capsule endoscopy to detect mucosal lesions and disease activity in ulcerative colitis (with video)

Evaluation of current status and near future perspectives of capsule endoscopy: Summary of Japan Digestive Disease Week 2019

“…A singlecenter study conducted in Hong Kong reported that although the capsule excretion rate was low (68%), second-generation PillCam Colon 2 yielded high accuracy in detecting mucosal lesions and determining disease severity among patients with UC, using colonoscopy as the reference. 4 Osawa et al (Session 8-7) also used the secondgeneration PillCam Colon 2 to analyze 55 examinations in patients with UC and reported that the rate of total colon observation (96.4%) and overall acceptability of patients were high. In addition, the disease activity according to the Mayo endoscopic subscore and UC endoscopic index of severity assessed by CCE correlated well with relapse-free survival.…”

Capsule Endoscopy: What We Know and What Is New in the Horizon

“…45 In a prospective study, CCE-2 had reported a sensitivity of 97% and 94% to detect mucosal inflammation (Mayo endoscopic subscore >0) and moderate-to-severe inflammation (Mayo endoscopic subscore >1), respectively, with negative predictive values to detect mucosal inflammation reaching 94 to 95%, respectively. 46 Advantages of CCE is that no sedation is needed and radiation, intubation, and insufflation are not involved. Contraindications for CCE are similar to that of CE.…”

Colon capsule endoscopy for inflammatory bowel disease

“…UC is a disease which limits to the colon and the role of CCE is therefore more extensively studied in UC. Up till now, there are seven studies comparing CCE with CC in suspected or confirmed UC (Table ). The first multicenter study enrolled 100 UC patients and compared the CCE‐1 with colonoscopy which reported a sensitivity of 89% and a specificity of 75% .…”

“…The CCE‐2 was also evaluated in more recent studies and all showed strong correlation (κ > 0.7 or P > 0.7 or ICC > 0.62) or high accuracy (sensitivity and specificity >70%) between CCE‐2 and CC. In pediatric patients, the sensitivity, specificity, positive (PPV) and negative predictive values (NPV) of CCE‐2 in detecting inflammation were as high as 96%, 100%, 100% and 85% .…”

“…First, the standard endoscopic scoring system of CCE for IBD disease activity was undefined . In UC, Shi et al . showed substantial intra‐ and inter‐observer agreements (ICC ranged from 0.81 to 0.97) when either Mayo endoscopic subscore (MES) or ulcerative colitis endoscopic index of severity (UCEIS) was used in UC patients.…”