A prospective study to investigate the relationship between periodontal disease and adverse pregnancy outcome

Moore, Sophie E.; Ide, Mark; Coward, P Y; Randhawa, Manjit; Borkowska, Edyta; Baylis, R; Wilson, Ron

doi:10.1038/sj.bdj.4811620

Cited by 203 publications

(224 citation statements)

References 34 publications

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“…4 The study confirms that insignificant-to strong associations between periodontal disease and poor pregnancy outcomes have been reported and that, interestingly, the strength of the association depends of the quality of the studies. The best-ranking studies 5,6 fail to report a significant association. The attempts to weight pooled results using quality scores are not enough to remove the noise.…”

Section: Commentarymentioning

confidence: 98%

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Is periodontal disease associated with poor pregnancy outcomes?

López

2007

Evid Based Dent

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What is the strength of association between periodontal disease in mothers and birth of their infants preterm or with low birthweights? Data sources Searches for studies were made using Medline, Embase, LILACS, Biosis and PASCAL and the reference lists of all identified articles were also checked for relevant reports. There were no restrictions on language of publication. Study selection Studies were selected if they were of cohort, case-control or cross-sectional design, with exposure defined as mother's periodontal disease and cases being defined as delivery at <37 weeks' gestation or infant with a birthweight <2500 g. Two reviewers independently evaluated articles for eligibility. Data extraction and synthesis Data from all eligible studies were extracted and summarised independently by two reviewers. Studies were combined to estimate the pooled odds ratio (OR) with 95% confidence intervals (CI) using the inverse variance method. Both fixed-effects and random effects models (based on the DerSimonian-Laird method) were used to calculate the overall OR. Results Seventeen articles met the inclusion criteria. A total of 7151 women participated in the studies, 1056 of whom delivered a preterm and/ or low birthweight infant. The overall OR was 2.83 (95% CI, 1.95-4.10; P 0.0001). This pooled value required cautious interpretation because there appeared to be a clear trend for the better quality studies to produce a lower strength of association. Conclusions These findings indicate a possible association, but this needs to be confirmed by large, well-designed, multicentre trials.

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Section: Commentarymentioning

confidence: 98%

“…In only two cohort studies, 7,8 which actually had the lowest quality scores in the review, did the authors reported a significant association, whereas the best and largest study included in the review (number of subjects, 3738) reported no association. 6 …”

Section: Commentarymentioning

confidence: 99%

Is periodontal disease associated with poor pregnancy outcomes?

López

2007

Evid Based Dent

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“…However, results have been mixed and several studies have not found associations between periodontal disease and preterm birth or low birthweight. (13)(14)(15) Systematic reviews of published studies tend to confirm a relationship between periodontal disease and preterm birth with an overall relative risk approaching 3. (16) Few studies on periodontal disease have examined women in developing countries, with very limited data available from Pakistan.…”

Section: Introductionmentioning

confidence: 99%

Periodontal disease and adverse birth outcomes: a study from Pakistan

Mobeen

Jehan

Banday

et al. 2008

American Journal of Obstetrics and Gynecology

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OBJECTIVES-Periodontal disease may increase the risk of adverse birth outcomes; however, results have been mixed. Few studies have examined periodontal disease in developing countries. We describe the relationship between periodontal disease and birth outcomes in a community setting in Pakistan. METHODS-Enrollment occurred at 20-26 wks.A study dentist performed the periodontal examination to assess probing depth (PD), clinical attachment level (CAL), gingivitis index (GI) and plaque index (PI). Outcomes included stillbirth, neonatal mortality, <32 wk preterm birth (PTB), 32-36 wk PTB, and low birthweight (LBW), and are presented for increasing periodontal disease severity by quartiles (Q1-4).RESULTS-Dental examinations and outcome data were completed for 1152 women. 81% were multiparous with a mean age of 27 yrs. 33% had no education. Dental caries were present in 47%, missing teeth in 27%, and 92% had no dental care in the last year. Periodontal disease was common: 87% had ≥ 4 teeth with a PD of >3mm, 54% had ≥4 teeth with a PI = 3, and 58% had ≥ 4 teeth with a GI = 3. In general, as the measure of periodontal disease increased, stillbirth, PTB <32 wks and neonatal mortality also increased. Late PTB and LBW were not related to measures of periodontal disease. Adjustment for demographic characteristics did not significantly change the relationships.

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“…Aborto tardío (AT): Moore y colaboradores lograron establecer en su estudio que la enfermedad periodontal se correlacionaba con AT, 32 aspecto que también se insinúa en el trabajo de Michalowickcz y colaboradores. 33 Sin embargo en la literatura revisada no se evidenció un modelo que permita analizar por las potenciales variables de confusión.…”

Section: La Condición Periodontal Y Su Efecto Sobre La Salud General unclassified

La Salud Oral De Las Mujeres Gestantes, Sus Repercusiones Y Los Aspectos Que Influencian Su Atención

Sánchez

2011

UstaSalud

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RESUMENLa salud oral de las mujeres gestantes no es buena, los cambios sistémicos y orales en la embarazada pueden comprometer no sólo la condición oral también la salud y la vida de la materna, el feto y del recién nacido. Los aspectos que inciden sobre la salud y la atención odontológica de la materna son muchos y deben analizarse de manera integral con el propósito de propiciar cambios que promuevan la salud y la vida de la mujer durante todo su ciclo vital pero en especial durante su embarazo. El objetivo de este artículo es describir los cambios que se presentan en un contexto general y oral en las gestantes; los efectos sobre su salud y la de su hijo y los aspectos que condicionan su atención odontológica. ORAL HEALTH IN PREGNANCY, REPERCUTIONS, AND ISSUES THAT INFLUENCE DENTAL ATTENTION ABSTRACTThe oral health in the pregnant is not good; the systemic and oral changes in the pregnant could affect the oral and general health and the life of the woman, the fetus and the new born. Several aspects affect the maternal oral health and the dental attention and they must be analyzed in integral way in order to changes and promote the health and the life of the woman in their vital cycle but especially during her pregnancy. The aim of this paper is to describe the changes that occur in a general context in pregnant women and oral, the effects on their health and that of his son, and the issues that affect their dental care.

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A prospective study to investigate the relationship between periodontal disease and adverse pregnancy outcome

Cited by 203 publications

References 34 publications

Is periodontal disease associated with poor pregnancy outcomes?

Is periodontal disease associated with poor pregnancy outcomes?

Periodontal disease and adverse birth outcomes: a study from Pakistan

La Salud Oral De Las Mujeres Gestantes, Sus Repercusiones Y Los Aspectos Que Influencian Su Atención

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