A prospective survey of risk factors in young adults with arterial occlusive disease

Aronson, Daniël C.; Ruys, Thomas A.; Bockel, J.H. van; Briët, E.; Brommer, E.J.P.; Leuven, J.A. Gevers; Kempen, H.J.M.; Feuth, J. D. M.; Giesberts, M. A. H.

doi:10.1016/s0950-821x(89)80087-8

Cited by 37 publications

(11 citation statements)

References 31 publications

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“…16 Numerous studies have found a poor prognosis for this virulent disease because these patients have higher rates of graft failure, reoperations, and amputations. [17][18][19][20][21][22][23] Saltzberg et al 17 studied outcomes in lower extremity revascularization in young diabetic patients and found a 30-day graft failure rate of 11.1%. They postulated that this may be a result of a more aggressive treatment taken in these younger patients with an attempt to perform a bypass to a suboptimal distal target rather than perform a primary amputation.…”

Section: Discussionmentioning

confidence: 99%

Factors associated with early failure of infrainguinal lower extremity arterial bypass

Singh

Sidawy

DeZee

et al. 2008

Journal of Vascular Surgery

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Section: Discussionmentioning

confidence: 99%

Factors associated with early failure of infrainguinal lower extremity arterial bypass

Singh

Sidawy

DeZee

et al. 2008

Journal of Vascular Surgery

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“…A genetic component of human vascular occlusive disease is well established (1,56). At least for the coronary circulation, tremendous variability exists between individuals in the formation of collateral vessels (8,21).…”

Section: Discussionmentioning

confidence: 99%

Impact of genetic background and aging on mesenteric collateral growth capacity in Fischer 344, Brown Norway, and Fischer 344 × Brown Norway hybrid rats

Sheridan

Ferguson

Distasi

et al. 2007

American Journal of Physiology-Heart and Circulatory Physiology

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Available studies indicate that both genetic background and aging influence collateral growth capacity, but it is not known how their combination affects collateral growth. We evaluated collateral growth induced by ileal artery ligation in Fischer 344 (F344), Brown Norway (BN), and the first generation hybrid of F344 × BN (F1) rats available for aging research from the National Institute on Aging. Collateral growth was determined by paired diameter measurements in anesthetized rats immediately and 7 days postligation. In 3-mo-old rats, significant collateral growth occurred only in BN (35% ± 11%, P < 0.001). The endothelial cell number in arterial cross sections was also determined, since this precedes shear-mediated luminal expansion. When compared with the same animal controls, the intimal cell number was increased only in BN rats (92% ± 21%, P < 0.001). The increase in intimal cell number and the degree of collateral luminal expansion in BN rats was not affected by age from 3 to 24 mo. Immunohistochemical studies demonstrated that intimal cell proliferation was much greater in the collaterals of BN than of F1 rats. The remarkable difference between these three strains of rats used in aging research and the lack of an age-related impairment in the BN rats are novel observations. These rat strains mimic clinical observations of interindividual variation in collateral growth capacity and the impact of age on arteriogenesis and should be useful models to investigate the molecular mechanisms responsible for such differences. Keywords strain dependent; endothelial proliferation; macrophage recruitmentAdvancing age is considered a major risk factor for vascular disease (22), including peripheral arterial disease (32). Arteriosclerosis, the most common arterial disease, results in vascular stenosis/occlusion and reduced tissue perfusion. Natural compensation to arterial occlusion includes the enlargement of preexisting bypass vessels (collaterals) and the formation of new vessels (angiogenesis). Of the two processes, collateral growth is the more efficient in restoring tissue perfusion (38,55,60). Recent human (31) and preclinical (36,51) Address for reprint requests and other correspondence: J. L. Unthank, Dept. of Surgery (WD OPW 425E), Indiana Univ. Medical Ctr, 1001 W. 10th St., Indianapolis, IN 46202-2879 (junthank@iupui.edu NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript studies have shown that the ability to compensate for arterial occlusion by collateral growth is impaired with advancing age. Yet, the specific mechanisms by which aging suppresses collateral growth remain poorly understood.Previous work in our laboratory has demonstrated an impairment in collateral growth in retired breeder Wistar rats (~8 to 10 mo of age) (51). This impairment was associated with abnormal protein expression in collateral vessels relative to the same animal controls. The first generation cross between the Fischer 344 (F344) and Brown Norway (BN) rats (F344 × BN or F1) is a rodent model promot...

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“…Studies also suggest that hyperhomocysteinaemia is associated with vein graft stenosis10–12. Thrombophilia and hyperhomocysteinaemia appear to be commoner in patients with peripheral vascular disease than in the general population10–23. The overall prevalence of thrombophilia defects and hyperhomocysteinaemia are difficult to calculate, as many of the studies were carried out in heterogeneous vascular populations or in early‐onset disease.…”

Section: Introductionmentioning

confidence: 99%

The prevalence of thrombophilia in patients with symptomatic peripheral vascular disease

Vig

Chitolie

Bevan

et al. 2006

British Journal of Surgery

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A prospective survey of risk factors in young adults with arterial occlusive disease

Cited by 37 publications

References 31 publications

Factors associated with early failure of infrainguinal lower extremity arterial bypass

Factors associated with early failure of infrainguinal lower extremity arterial bypass

Impact of genetic background and aging on mesenteric collateral growth capacity in Fischer 344, Brown Norway, and Fischer 344 × Brown Norway hybrid rats

The prevalence of thrombophilia in patients with symptomatic peripheral vascular disease

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