A prospective trial comparing sequential day 3/day 5 transfer with cleavage stage transfer and blastocyst stage transfer

Dalal, Rutvij Jay; Mishra, Akanksha; Pai, Hrishikesh; Palshetkar, Nandita

doi:10.4103/2348-2907.151972

Cited by 7 publications

(10 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Systematic risk assessment of methodological bias of included RCTs revealed three RCTs did not[ 23 , 26 , 27 ]clearly describe an acceptable method of sequence generation and five RCTs[ 23 , 25 – 28 ]did not clearly describe their methods of allocation concealment, therefore, we rated them at unclear risk of bias. We rated one study [ 28 ] at unclear risk in attribution bias domain, because the general random patients were not reported and we were unable to determine the integrity of data.…”

Section: Resultsmentioning

confidence: 99%

Reduced Ectopic Pregnancy Rate on Day 5 Embryo Transfer Compared with Day 3: A Meta-Analysis

et al. 2017

View full text Add to dashboard Cite

ObjectiveTo compare the risk of ectopic pregnancy (EP) after embryo transfer on day 3(D3-ET) and day 5(D5-ET).DesignMeta-analysisPatientsWomen with pregnancy resulting from in vitro undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI)Result(s)Twenty-two studies were identified through research conducted using the PubMed, Embase, and Cochrane databases and ClinicalTrials.gov. All studies were conducted prior to October 2016. Adding the reproductive data from our center, a total of 143 643 pregnancies were reviewed(D3-ET: n = 62027,D5-ET:n = 81616). A lower EP rate was found in women undergoing D5-ET than in those undergoing D3-ET [relative risk (RR), 0.67;95% confidence interval (CI), 0.54–0.85;143643 pregnancies in 23 studies; I2 = 67%]. These results were validated in subgroups of fresh embryo-transfer (Fre-ET) cycles [RR, 0.78; 95%CI, 0.69–0.88; 91 871 pregnancies in 21 studies; I2 = 29%] and frozen-thawed embryo-transfer (Fro-ET) cycles [RR, 0.43; 95%CI, 0.36–0.51; 51 772 pregnancies in 10 studies; I2 = 33%]. After separating out the randomized controlled trials (RCTs), a significant difference was found in the retrospective studies in both subgroups [both Fre-ET (RR,0.78;95% CI 0.69–0.88);91182 pregnancies in 14 studies; I2 = 45%] and Fro-ET(RR,0.43;95% CI 0.36–0.51; 51751pregnancies in 9 studies;I2 = 33%)], while the RCTs showed no statistical significance for Fre-ET cycles[RR,0.86;95% CI 0.32–2.26); 689 pregnancies in 7 studies; I2 = 0%].Conclusion(s)The present study indicates that D5-ET reduces the risk for EP in cycles that use IVF or ICSI, compared with D3-ET. It suggests that D5-ET may be a better choice for decreasing the EP rate in assisted reproductive technology. Further high-quality randomized controlled trials are anticipated.

show abstract

Section: Resultsmentioning

confidence: 99%

Reduced Ectopic Pregnancy Rate on Day 5 Embryo Transfer Compared with Day 3: A Meta-Analysis

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Our study is consistent with other studies that concluded that sequential transfers had signiﬁcantly higher pregnancy, implantation, and live birth rates, compared to conventional day-3 transfers ( Nadkarni et al ., 2015 ; Dalal et al ., 2015 ; Ismail Madkour et al ., 2015 ). Stamenov et al .…”

Section: Discussionmentioning

confidence: 99%

“…Blastocyst transfer resembles the natural cycle as the embryo normally arrives inside the uterine cavity from the fallopian tube at the blastocyst stage. Blastocyst transfers also bear better embryo euploidy status than cleavage stage transfers ( Dalal et al ., 2015 ). Blastocyst cultures yield better results in pre-implantation genetic testing for monogenic gene defects (PGT-M), or pre-implantation genetic testing for aneuploidies (PGT-A).…”

Section: Introductionmentioning

confidence: 99%

“…Blastocyst cultures yield better results in pre-implantation genetic testing for monogenic gene defects (PGT-M), or pre-implantation genetic testing for aneuploidies (PGT-A). Accordingly, many authorities have recommended adopting the policy of “pure” blastocyst transfer, rather than cleavage transfer ( Dalal et al ., 2015 ). We know that blastocyst transfers are superior to cleavage stage embryo transfers, vis-à-vis the implantation potential, as the probability of synchronized endometrial receptivity and embryonic development rises, leading to a rise in the implantation rate, which is the determining factor in IVF success (although live birth rate is considered the gold standard).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Comparing sequential vs day 3 vs day 5 embryo transfers in cases with recurrent implantation failure: randomized controlled trial

Torky

Ahmad²,

Hussein

et al. 2021

JBRA Assisted Reproduction

View full text Add to dashboard Cite

“…4 We got twin pregnancies in 12% of our patient Dalal et al found multiple pregnancy rate of 15.3% in the sequential transfer group. 5 Alone blastocyst transfer on day 5 can have high cancelation rates because if no blastocyst is formed than no embryo can be transferred. Cycle cancelation rates were nil in our study.…”

Section: Discussionmentioning

confidence: 99%

Assessment of the pregnancy rates using sequential day 3 and day 5 embryo transfer in IVF/ ICSI patients

Agrawal¹,

Agrawal²,

Lobo³

2021

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

Background: To assess the pregnancy rates using sequential day 3 and day 5 embryo transfer in IVF/ ICSI patients.Methods: This prospective study was conducted in Aarogya Hospital and test tube baby Centre, Raipur from 1st January 2013 to 30th November 2019. Total 100 patients undergoing IVF/ICSI in the study period were offered sequential transfer.Results: Our fertilization rates were 80% with 85.7% grade I embryos on day 3. Blastocyst formation rate was 71.42%. Cycle cancellation rates were nil. Clinical pregnancy rates per retrieval cycle were 50% and implantation rates were 24% with acceptable multiple pregnancy rates of 12%.Conclusions: We advocate that this technique is useful in all patients having good quality embryos in adequate number for double transfer as this optimizes the chance of selection of the most viable embryo for transfer which is probably the key for a successful IVF program.

show abstract

A prospective trial comparing sequential day 3/day 5 transfer with cleavage stage transfer and blastocyst stage transfer

Cited by 7 publications

References 0 publications

Reduced Ectopic Pregnancy Rate on Day 5 Embryo Transfer Compared with Day 3: A Meta-Analysis

Reduced Ectopic Pregnancy Rate on Day 5 Embryo Transfer Compared with Day 3: A Meta-Analysis

Comparing sequential vs day 3 vs day 5 embryo transfers in cases with recurrent implantation failure: randomized controlled trial

Assessment of the pregnancy rates using sequential day 3 and day 5 embryo transfer in IVF/ ICSI patients

Contact Info

Product

Resources

About