A Prospective Two Center Study Comparing Breast Cancer Lesion Size Defined by 2D Shear Wave Elastography, B-Mode Ultrasound, and Mammography with the Histopathological Size

Farrokh, André; Treu, Linn; Öhlinger, R.; Flieger, Carolin; Maass, Nicolaì; Schäfer, Fritz K. W.

doi:10.1055/a-0661-5952

Cited by 6 publications

(4 citation statements)

References 28 publications

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“…Farrokh et al [ 1 ] recently reported data that proves that USWE is much more precise for measuring cancer size. Another study by Farrokh et al [ 41 ] confirmed that USWE can predict the lesion size precisely compared to other modalities.…”

Section: Discussionmentioning

confidence: 93%

Preoperative imaging accuracy in size determination of prostate cancer in men undergoing radical prostatectomy for clinically localised disease

Ageeli,

Soha,

Zhang

et al. 2023

Insights Imaging

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Objectives To compare the accuracy of pre-surgical prostate size measurements using mpMRI and USWE with imaging-based 3D-printed patient-specific whole-mount moulds facilitated histopathology, and to assess whether size assessment varies between clinically significant and non-significant cancerous lesions including their locations in different zones of the prostate. Methods The study population included 202 men with clinically localised prostate cancer opting for radical surgery derived from two prospective studies. Protocol-based imaging data was used for measurement of size of prostate cancer in clinically localised disease using MRI (N = 106; USWE (N = 96). Forty-eight men overlapped between two studies and formed the validation cohort. The primary outcome of this study was to assess the accuracy of pre-surgical prostate cancerous size measurements using mpMRI and USWE with imaging-based 3D-printed patient-specific whole-mount moulds facilitated histopathology as a reference standard. Independent-samples T-tests were used for the continuous variables and a nonparametric Mann–Whitney U test for independent samples was applied to examine the distribution and median differences between mpMRI and USWE groups. Results A significant number of men had underestimation of prostate cancer using both mpMRI (82.1%; 87/106) and USWE (64.6%; 62/96). On average, tumour size was underestimated by a median size of 7 mm in mpMRI, and 1 mm in USWE. There were 327 cancerous lesions (153 with mpMRI and 174 for USWE). mpMRI and USWE underestimated the majority of cancerous lesions (108/153; 70.6%) and (88/174; 50.6%), respectively. Validation cohort data confirmed these findings MRI had a nearly 20% higher underestimation rate than USWE (χ2 (1, N = 327) = 13.580, p = 0.001); especially in the mid and apical level of the gland. Clinically non-significant cancers were underestimated in significantly higher numbers in comparison to clinically significant cancers. Conclusions Size measurement of prostate cancers on preoperative imaging utilising maximum linear extent technique, underestimated the extent of cancer. Further research is needed to confirm our observations using different sequences, methods and approaches for cancer size measurement.

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Section: Discussionmentioning

confidence: 93%

Preoperative imaging accuracy in size determination of prostate cancer in men undergoing radical prostatectomy for clinically localised disease

Ageeli,

Soha,

Zhang

et al. 2023

Insights Imaging

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“…The breasts are in front of the chest and bulge forward, with very rich lymphatic drainage. There are abundant lymphatic vessels under the breast skin and under the nipples [18]. Most of the lymph flow from the outside of the breasts to the anterior thoracic lymph nodes and then to the axillary lymph nodes [19].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Property of Axillary Lymph Nodes and Analysis of Lymph Node Metastasis Factors in Breast Cancer by Ultrasound Elastography

Zhou

Zhang

et al. 2022

Computational and Mathematical Methods in Medicine

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This research was aimed at investigating the role of ultrasound elastography (UE) in evaluating the properties of axillary lymph nodes in breast cancer and exploring the influencing factors of lymph node metastasis in breast cancer patients. Routine ultrasonography (US) and UE were performed for 160 breast cancer patients. 80 cases were in the group with lymph node metastasis, and the other 80 were in the nonlymph node metastasis group. The sensitivity, specificity, and accuracy of the two ultrasound examinations were compared, the receiver-operator characteristic (ROC) curves were drawn, and the influencing factors of lymph node metastasis were analyzed. The sensitivity, specificity, and accuracy of UE in diagnosing axillary lymph nodes of breast cancer were 97.22%, 95.45%, and 96.25%, respectively, which were markedly higher than those of routine US ( P < 0.05 ). Cortical thickness, blood flow grade, blood flow type, and elasticity score had a greater impact on axillary lymph node metastasis of breast cancer. When cortical thickness ≥ 3 cm , blood flow was of 2-3 grades, blood flow was the peripheral/mixed type, and elasticity score was 3-4 points, these became risk factors for lymph node metastasis in breast cancer patients. UE was effective in diagnosing the property of lymph nodes and could evaluate lymph node metastasis in breast cancer patients. It had a good clinical value and was worthy of popularization and application.

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“…Pinker et al (2018) [19] pointed out that ADC value was one of the most important indicators reflecting the characteristics of dispersion, and it could reflect the density and growth of BT tissue, which was a very important criterion for tumor diagnosis. Farrokh et al ( 2019) [20] pointed out that the histological grade of BT was correlated with the size of the lesion. It was found in this study that the lesion diameters of grade II and grade III were concentrated at 1.5-2.5 cm and 2.5-3.5 cm, respectively (P < 0.05), indicating that there was indeed a certain correlation.…”

Section: Discussionmentioning

confidence: 99%

MRI Images Based on Semiautomatic Segmentation Algorithm for Prediction of Histological Grade of Breast Tumor

Wang

Zhou

Sun

et al. 2022

Scientific Programming

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This study aimed to explore the effects of delayed enhanced magnetic resonance imaging (MRI) (DE-MRI) image features based on the semiautomatic circle-dependent (SCD)-based multiphase level set (MLS) (SCD-MLS) algorithm in predicting the histological grade of breast tumors. We explore the clinical effect of DE-MRI on the prediction of the histological grade of breast tumors (BTs). In this study, 264 breast tumor (BT) patients from The Second Affiliated Hospital of Soochow University were selected as the research objects, and DE-MRI examinations were performed. The SCD-MLS algorithm was compared with the Live-Wire algorithm for the segmentation effect and was applied to the DE-MRI image for prediction of the histological grade of BT. The results proved that the SCD-MLS algorithm in this study showed a more accurate segmentation effect with good stability. BT tissue showed a patchy low signal on T1WI and a high signal on T2WI. The number of patients with grade II was the highest (P < 0.05); the lesion diameters of grade II and grade III were concentrated at 1.5–2.5 cm and 2.5–3.5 cm, respectively (P < 0.05); the fractional anisotropy (FA) of patients with grade I was the largest (P < 0.05); and the apparent diffusion coefficient (ADC) of the patients with grade III was the highest (P < 0.05). In short, DE-MRI showed a good performance in the BT diagnosis, and the grading of BT tissue was related to lesion size, number of lesions, ADC, and FA.

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A Prospective Two Center Study Comparing Breast Cancer Lesion Size Defined by 2D Shear Wave Elastography, B-Mode Ultrasound, and Mammography with the Histopathological Size

Abstract: 2 D SWE predicted lesion size more precisely than B-mode ultrasound or mammography. In cases of invasive lobular carcinoma, all three imaging methods underestimated lesion size, with 2 D SWE coming closest to the actual tumor size.

Cited by 6 publications

References 28 publications

Preoperative imaging accuracy in size determination of prostate cancer in men undergoing radical prostatectomy for clinically localised disease

Preoperative imaging accuracy in size determination of prostate cancer in men undergoing radical prostatectomy for clinically localised disease

Evaluation of the Property of Axillary Lymph Nodes and Analysis of Lymph Node Metastasis Factors in Breast Cancer by Ultrasound Elastography

MRI Images Based on Semiautomatic Segmentation Algorithm for Prediction of Histological Grade of Breast Tumor

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