A protective effect of breastfeeding on the progression of non-alcoholic fatty liver disease

Nobili, Valério; Bedogni, Giorgio; Alisi, Anna; Pietrobattista, Andrea; Alterio, Arianna; Tiribelli, Claudio; Agostoni, Carlo

doi:10.1136/adc.2009.159566

Cited by 80 publications

(56 citation statements)

References 46 publications

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“…Studies in rats showed that the liver might act as a systemic buffer, largely increasing its lipid content in the early stage of high-fat feeding [34]. It has been suggested that breastfeeding protects against the development of nonalcoholic steatohepatitis (NASH) in children [35]. We did not have sufficient nutritional data to investigate differences in nutritional intake in early life between adults born preterm and those born at full term and its relation with growth in infancy and the risk for NAFLD, but our results warrant further investigations.…”

Section: Discussionmentioning

confidence: 99%

Risk for Nonalcoholic Fatty Liver Disease in Young Adults Born Preterm

2015

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Background: Nonalcoholic fatty liver disease (NAFLD) is considered the hepatic manifestation of metabolic syndrome. Accelerated catch-up in weight during infancy in subjects born at full term has been associated with increased risk for NAFLD in adulthood, but this association has not been studied in subjects born preterm. Methods: In 162 young adults born at a gestational age <36 weeks, we assessed the associations between fatty liver index (FLI, 0-100) and birth weight standard deviation score and first-year weight gain. We performed comparisons between subjects with and without accelerated catch-up in weight in the first year after term age. An FLI score was assigned to each participant to determine the clinical relevance, and regression analyses were performed. Results: Accelerated weight gain in the first 3 months after term age was associated with FLI as a continuous variable, whereas gestational age and low birth weight were not. Of the subjects with accelerated catch-up in weight-for-length after term age, 7.3% had a high FLI at the age of 21 years, whereas none of the subjects without accelerated catch-up in weight had a high FLI. Conclusion: Our study shows that accelerated weight gain after term age is associated with an increased risk of developing NAFLD in young adults born preterm.

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Section: Discussionmentioning

confidence: 99%

Risk for Nonalcoholic Fatty Liver Disease in Young Adults Born Preterm

2015

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“…[99][100][101][102] There is preliminary evidence suggesting that breast feeding may also affect the later expression of NAFLD, protecting the liver from the development of non-alcoholic steatohepatitis and fibrosis. 103 …”

Section: Evidence For Liver Programmingmentioning

confidence: 99%

Effect of intrauterine growth retardation on liver and long-term metabolic risk

Cianfarani

Agostoni

Bedogni³

et al. 2012

Int J Obes

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Intrauterine growth retardation predisposes toward long-term morbidity from type 2 diabetes and cardiovascular disease. To explain this association, the concept of programming was introduced to indicate a process whereby a stimulus or insult at a critical period of development has lasting or lifelong consequences on key endocrine and metabolic pathways. Subtle changes in cell composition of tissues, induced by suboptimal conditions in utero, can influence postnatal physiological functions. There is increasing evidence, suggesting that liver may represent one of the candidate organs targeted by programming, undergoing structural, functional and epigenetic changes following exposure to an unfavorable intrauterine environment. The aim of this review is to provide insights into the molecular mechanisms underlying liver programming that contribute to increase the cardiometabolic risk in subjects with intrauterine growth restriction.

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“…An effect of maternal high-fat diet on offspring liver triglyceride content has also been shown in non-human primates in which the offspring of females maintained long-term on a high-fat diet had increased liver triglyceride content and evidence of increased hepatic oxidative stress whether or not their mothers had become obese, suggesting that programming of liver fat may be independent of maternal obesity, at least in this model (McCurdy et al 2009). The impact of maternal obesity in humans on offspring development of non-alcoholic fatty liver disease has not been studied, although preliminary evidence suggests that early feeding habits may impact on development of fatty liver disease in childhood suggesting a potential role for early life experience in development of this condition (Nobili et al 2009). …”

Section: Non-alcoholic Fatty Liver Diseasementioning

confidence: 99%

Impact of maternal obesity on offspring obesity and cardiometabolic disease risk

Drake¹,

Reynolds²

2010

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445

308

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The prevalence of obesity among pregnant women is increasing. In addition to the short-term complications of obesity during pregnancy in both mother and child, it is now recognised that maternal obesity has long-term adverse outcomes for the health of her offspring in later life. Evidence from both animal and human studies indicates that maternal obesity increases the risk for the offspring in developing obesity and altering body composition in child-and adulthood and, additionally, it also has an impact on the offspring's cardiometabolic health with dysregulation of metabolism including glucose/insulin homoeostasis, and development of hypertension and vascular dysfunction. Potential mechanisms include effects on the development and function of adipose tissue, pancreas, muscle, liver, the vasculature and the brain. Further studies are required to elucidate the mechanisms underpinning the programming of disease risk in the offspring as a consequence of maternal obesity. The ultimate aim is to identify potential targets, which may be amenable to prevention or early intervention in order to improve the health of this and future generations.

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A protective effect of breastfeeding on the progression of non-alcoholic fatty liver disease

Abstract: This observational study suggests that earlier feeding habits might affect the clinical expression of NASH from 3 to 18 years later, with an apparent drug-like preventive effect of breastfeeding.

Cited by 80 publications

References 46 publications

Risk for Nonalcoholic Fatty Liver Disease in Young Adults Born Preterm

Risk for Nonalcoholic Fatty Liver Disease in Young Adults Born Preterm

Effect of intrauterine growth retardation on liver and long-term metabolic risk

Impact of maternal obesity on offspring obesity and cardiometabolic disease risk

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