A protective effect of coenzyme Q10 on ischemia and reperfusion of the isolated perfused rat heart

Ohhara, Hideto

doi:10.1016/0022-2828(81)90229-7

Cited by 68 publications

(16 citation statements)

References 11 publications

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“…Episodes of regional ischemia longer than 10 minutes also lead to regional myocardial dysfunction (20,29,51). A time course for ATP recovery similar to the return of regional postischemic contractile dysfunction was observed (29), and it was hypothesized by some authors (18,(36)(37)(38), but not by others (16,52) that a causal relationship exists between ATP content and function.…”

Section: Introductionmentioning

confidence: 86%

“…In various experimental settings a relation between ATP and myocardial function was seen, i.e. in the rabbit heart (35), after cardioplegia (37), and with global ischemia without cardioplegia in the rat (36), while other authors could not confirm such a close relationship (16,52). Kanaide and coworkers reported that dysfunction of the ischemic region precedes a substantial loss of ATP production and content (26).…”

Section: ~mentioning

confidence: 93%

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Effect of adenosine and AICAR on ATP content and regional contractile function in reperfused canine myocardium

1985

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We investigated whether the postischemic acceleration of adenosine triphosphate (ATP) synthesis by means of precursor infusion is beneficial for the contractile function of reperfused myocardium. A coronary artery was occluded for 45 min in 21 dogs to produce a marked but reversible ischemia. During the following 3 hours of reperfusion either adenosine (n = 6) or AICAR (5-amino-imidazole-4-carboxamide-riboside) (n = 6) was infused intracoronarily by a small transfemoral catheter positioned in the LAD. ATP repletion by adenosine was nearly 50% of the deficit caused by the previous ischemia, the effect of AICAR on steady-state tissue ATP concentration was insignificant. Regional systolic function of these both groups was compared to that of a control group (n = 9) receiving only a saline infusion. We measured the regional function by subendocardially implanted ultrasound transducers using the transit time method. All three groups showed a reduction to about 25% of the initial segment shortening at the end of ischemia, followed by a quick recovery to half of the preocclusion segment shortening after reopening of the vessel. No further changes were observed in the control series during the 3 hours of reperfusion (50 +/- 10% SE segment shortening at the end). With adenosine infusion - in spite of the resulting considerable ATP elevation - no significant change of segmental contractile function occurred (44 +/- 5% SE segment shortening). Only the AICAR treated group differed from control. It produced a continuous deterioration during reflow resulting in a holosystolic bulging of -20% +/- 10% SE at the end of 3 hours of reperfusion. Our results show that there is no correlation between different ATP tissue levels achieved by adenosine infusion and systolic function in reperfused myocardium after regional reversible ischemia. We hypothesize that reperfusion dyskinesia is caused by a failure of energy utilisation rather than of energy supply.

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Section: Introductionmentioning

confidence: 86%

Section: ~mentioning

confidence: 93%

Effect of adenosine and AICAR on ATP content and regional contractile function in reperfused canine myocardium

1985

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“…When given prior to ischemia, the release of AMP catabolites was markedly reduced so that there was an effective preservation of high energy phosphates (2,3). A similar effect on both ATP and total adenine nucleotide contents in rat hearts during postischemic reperfusion has been demonstrated for coenzyme Q10 (15).…”

Section: Introductionmentioning

confidence: 62%

“…It has already been shown by other research groups that coenzyme Q10 attenuated the decline of ATP in the ischemic heart (11) and accelerated the ATP restoration during postischemic reperfusion (15). This coincided with improved myocardial segment shortening in the ischemic area of the dog heart (11) and with a higher developed tension and a greater reduction in resting tension during the postischemic reperfusion period in the rat heart (15). Coenzyme Q10 is a naturally occurring component of the mitochondrial respiratory chain and links the flavoprotein to cytochrome b.…”

Section: Discussionmentioning

confidence: 95%

Myocardial infarction in rats: effects of metabolic and pharmacologic interventions

1989

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Myocardial infarction was induced in rats by ligation of the descending branch of the left coronary artery. The time course of changes in heart function was recorded within the first nine days. There was a progressive decline in LVSP, in LV dP/dtmax and in the pressure-rate-product. LVEDP was elevated. Cardiac output and stroke volume index were depressed after two days. The ATP content in the nonischemic region was lower than control, but recovered spontaneously toward the normal value within the first four days. Three metabolic and pharmacologic interventions known to affect cardiac adenine nucleotide metabolism were applied. Continuous i.v. administration of ribose which stimulates further adenine nucleotide biosynthesis attenuated the fall and promoted the restoration of ATP in the nonischemic myocardium within four days after coronary artery ligation. The elevation of LVEDP was attenuated with ribose after two and four days. The calcium antagonist gallopamil administered as i.v. infusion for two days led to a further reduction of all parameters of left heart function, but did not influence the increase in adenine nucleotide and protein synthesis that occurred in the nonischemic heart. Coenzyme Q10 had only slight effects on LVSP, LVEDP, and LV dP/dtmax, but attenuated significantly the fall in cardiac output and stroke volume index after two days following coronary artery ligation. Thus, all interventions affected differently the infarct-induced changes in heart and circulatory function. An improvement was observed with ribose and with coenzyme Q10.

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“…15 Ohhara et al 33 found that CoQ 10 protected against ischemia and reperfusion in the heart. CoQ 10 can interfere with the spontaneous progression of the disease through a stabilizing effect and shares the possible advantage of avoiding the need for surgery.…”

Section: Discussionmentioning

confidence: 99%

Safety and efficacy of coenzyme Q10 supplementation in early chronic Peyronie's disease: a double-blind, placebo-controlled randomized study

Safarinejad¹

2010

Int J Impot Res

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A protective effect of coenzyme Q10 on ischemia and reperfusion of the isolated perfused rat heart

Cited by 68 publications

References 11 publications

Effect of adenosine and AICAR on ATP content and regional contractile function in reperfused canine myocardium

Effect of adenosine and AICAR on ATP content and regional contractile function in reperfused canine myocardium

Myocardial infarction in rats: effects of metabolic and pharmacologic interventions

Safety and efficacy of coenzyme Q10 supplementation in early chronic Peyronie's disease: a double-blind, placebo-controlled randomized study

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