A protective effect of curcumin on cardiovascular oxidative stress indicators in systemic inflammation induced by lipopolysaccharide in rats

Ahmadabady, Somaieh; Beheshti, Farimah; Shahidpour, Fatemeh; Khordad, Elnaz; Hosseini, Mahmoud

doi:10.1016/j.bbrep.2021.100908

Cited by 31 publications

(26 citation statements)

References 52 publications

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“…In our study, endotoxin/LPS induced oxidative stress markers in an in vivo model as demonstrated by the decreased cardiac antioxidant capacities and the increased MDA level. Our results were in agreement with other reports ( Goraca, Piechota & Huk-Kolega, 2009 ; Plotnikov et al, 2017 ; Ahmadabady et al, 2021 ). In fact, the local increase of MDA indicates reactive oxygen species (ROS)-dependent tissue damage ( Kwiecien et al, 2014 ).…”

Section: Discussionsupporting

confidence: 94%

In vivo evaluation of the protective effects of arjunolic acid against lipopolysaccharide-induced septic myocardial injury

Almalki

Elmenshawy

Abdel‐Moneim

2022

PeerJ

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Lipopolysaccharide (LPS) is a glycolipid component of the cell wall of Gram-negative bacteria, which induces multiple organ dysfunctions, eventually leading to septic shock and death. Arjunolic acid (AA) has been shown to have therapeutic benefits against various organ pathophysiologies, although its role in sepsis remains unclear. Here, we evaluated the effects of AA on LPS-induced free radical production and cardiotoxicity. Male albino mice were allocated to four groups: normal, 1.5 µg/30 g b.w. of LPS (LPS), 20 mg/kg b.w. AA with LPS (AA+LPS) and 20 mg/kg b.w. of AA (AA). Subsequently, blood and heart samples were harvested for biochemical and histopathological examinations. Pretreatment with AA attenuated LPS-induced increased serum levels of cardiac troponin I, lactate dehydrogenase and creatine kinase. In the meantime, AA pretreatment before LPS resulted in a significant increase in endogenous antioxidants (superoxide dismutase, catalase, glutathione peroxidase and reduced glutathione) and a significant decrease in the level of lipid peroxidation product (malondialdehyde) in the heart as compared to the LPS group, while cardiac cytochrome c activity were significantly increased. In addition, in the AA-pretreated mice, C-reactive protein and proinflammatory cytokines (interlukin-1 and tumor necrosis factor-alpha) were significantly reduced, and anti-inflammatory cytokines (interleukin-4 and -10) were significantly increased in cardiac tissues as compared to the LPS-treated animals. Furthermore, prior administration of AA to LPS exposed mice led to a significant a significant decrease in heart caspase-3, -8, and -9 as compared to the LPS group. Interestingly, AA was also able to improve LPS-induced histopathological changes in the cardiomyocytes. In conclusion, these in vivo findings indicate that AA may be a promising cardioprotective agent against LPS-stimulated cardiotoxicity, at least in part, through upregulation of cardiac antioxidants, reduction of lipid peroxidation, and inhibition of inflammation and cardiac cell death.

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Section: Discussionsupporting

confidence: 94%

In vivo evaluation of the protective effects of arjunolic acid against lipopolysaccharide-induced septic myocardial injury

Almalki

Elmenshawy

Abdel‐Moneim

2022

PeerJ

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“…In opposition to our findings, an experimental study concluded that curcumin significantly reduced blood pressure and might be useful in the regulation of hypertension and cerebral microcirculatory function in male albino rats (Xia et al, 2016). It should be mentioned that the different nature and design of this study may cause inconsistent and heme oxygenase-1 (HO-1), as well as improving hematological parameters (Ahmadabady et al, 2021;Boroumand et al, 2018;Gupta & Gupta, 2019;Karimi et al, 2019;Liang et al, 2009;Silva et al, 2017;Youn et al, 2006). Prior clinical studies have suggested that hematological parameters play an influential role in the prognosis of sepsis patients (Gupta & Gupta, 2019).…”

Section: Clinical Outcomescontrasting

confidence: 93%

“…Also, the length of ICU stay did not significantly change between the nano‐curcumin and placebo groups. In addition, an in vivo study by Ahmadabady et al (2021) investigated the impact of curcumin on systemic inflammation in LPS‐challenged rats found that administration of 10 and 15 mg/kg curcumin markedly decreased WBC. Moreover, in experimentally induced arthritic rats, curcumin supplementation led to a significant reduction in WBC (Kamarudin et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Does nano‐curcumin supplementation improve hematological indices in critically ill patients with sepsis? A randomized controlled clinical trial

Naeini

Tutunchi

Razmi

et al. 2022

Journal of Food Biochemistry

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Sepsis is the final common pathway to death for severe infectious diseases worldwide. The present trial aimed to investigate the effects of nano‐curcumin supplementation on hematological indices in critically ill patients with sepsis. Fourteen ICU‐admitted patients were randomly allocated into either nano‐curcumin or placebo group for 10 days. The blood indices, serum levels of inflammatory biomarker and presepsin as well as nutrition status, and clinical outcomes were assessed before the intervention and on days 5 and 10. White blood cells, neutrophils, platelets, erythrocyte sedimentation rate (ESR), and the levels of interleukin‐8 significantly decreased in the nano‐curcumin group compared to the placebo after 10 days of intervention (p = .024, p = .045, p = .017, p = .041, and p = .004, respectively). There was also a marginal meaningful decrease in serum presepsin levels in the intervention group compared to the placebo at the end of the study (p = .054). However, total lymphocyte count showed a significant increase in the nano‐curcumin group compared to the placebo at the end‐point (p = .04). No significant differences were found in the level of lymphocyte and the ratios of neutrophil/lymphocyte and platelet/lymphocyte between the study groups. Moreover, no significant between‐group differences were observed for other study outcomes, post‐intervention. Collectively, nano‐curcumin may be a useful adjuvant therapy in critically ill patients with sepsis. However, further trials are suggested to examine the effects of nano‐curcumin in the management of sepsis and its complications. Practical applications Curcumin (1,7‐bis[4‐hydroxy‐3‐methoxyphenyl]‐1,6‐heptadiene‐3,5‐ dione) or diferuloylmethane is widely used in medicine due to its several biological properties. Recent evidence has shown that curcumin possesses multiple pharmacological activities including immune‐modulatory, antioxidant, anti‐inflammatory, anti‐cancer, and anti‐microbial effects. In this study, it was observed that nano‐curcumin at a dose of 160 mg for 10 days, without side effects, reduced some inflammatory factors and regulated the immune responses in sepsis patients. For the first time, this trial was conducted to determine the effect of nano‐curcumin on hematological indices and the serum levels of presepsin and IL‐8.

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“…Further, cardiac ČAT activation by adipokine apelin during hypertrophic remodeling manifests protective features versus ROS in male Č57BL6/J mice and cultures of cardiac myocytes [74]. Similarly, in experimental male rats, ČAT reactivation by curcumin in the heart and aorta displays protective properties against lipopolysaccharide [75]. In addition, results from Dai et al [76] study showed that ČAT upregulation in mitochondria protects male and female mice from vascular aging.…”

Section: Role Of Antioxidant Enzymes In Vascular Diseasesmentioning

confidence: 97%

Antioxidant enzymes and vascular diseases

Radovanović

Banjac

Obradović

et al. 2021

Exploration of Medicine

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Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play a fundamental role in regulating endothelial function and vascular tone in the physiological conditions of a vascular system. However, oxidative stress has detrimental effects on human health, and numerous studies confirmed that high ROS/RNS production contributes to the initiation and progression of cardiovascular diseases. The antioxidant defense has an essential role in the homeostatic functioning of the vascular endothelial system. Endogenous antioxidative defense includes various molecules and enzymes such as superoxide dismutase, catalase, glutathione reductase, and glutathione peroxidase. Together all these antioxidative enzymes are essential for defense against harmful ROS features. ROS are mainly generated from redox-active compounds involved in the mitochondrial respiratory chain. Thus, targeting antioxidative enzymes and mitochondria oxidative balance may be a promising approach for vascular diseases occurrence and treatment. This review summarized the most recent research on the regulation of antioxidative enzymes in vascular diseases.

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A protective effect of curcumin on cardiovascular oxidative stress indicators in systemic inflammation induced by lipopolysaccharide in rats

Cited by 31 publications

References 52 publications

In vivo evaluation of the protective effects of arjunolic acid against lipopolysaccharide-induced septic myocardial injury

In vivo evaluation of the protective effects of arjunolic acid against lipopolysaccharide-induced septic myocardial injury

Does nano‐curcumin supplementation improve hematological indices in critically ill patients with sepsis? A randomized controlled clinical trial

Antioxidant enzymes and vascular diseases

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