A protective effect of pyrrolidine dithiocarbamate in a rat model of liver cirrhosis

Bruck, Rafael; Schey, Ron; Aeed, Hussein; Hochman, Ayala; Genina, Olga; Pines, Mark

doi:10.1111/j.1478-3231.2004.00900.x

Cited by 41 publications

(27 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a human liver (AKN-1) epithelial cell line, PDTC significantly suppresses inducible nitric-oxide synthase expression and NO synthesis after cytokine stimulation (41). It exerts also protection in rat models of liver injury (42,43) and inhibits the production of IL-6 by human endothelial cells in response to inflammatory mediators (44). Therefore, it is likely that PDTC is involved in attenuating the inflammatory response.…”

Section: Discussionmentioning

confidence: 99%

Pyrrolidine Dithiocarbamate Inhibits Interleukin-6 Signaling through Impaired STAT3 Activation and Association with Transcriptional Coactivators in Hepatocytes

Zhu

Xie

et al. 2006

J. Biol. Chem.

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Pyrrolidine Dithiocarbamate Inhibits Interleukin-6 Signaling through Impaired STAT3 Activation and Association with Transcriptional Coactivators in Hepatocytes

Zhu

Xie

et al. 2006

J. Biol. Chem.

View full text Add to dashboard Cite

“…Critically, NF-kB is constitutively active in pro-fibrogenic liver myofibroblasts due to an excess of Rel factors via an epigenetic down-regulation of the inhibitory IkB protein . Interestingly, some drugs have shown important benefits for liver damage that may be acting by decreasing activation of the NF-kB pathways (Bruck et al, 2004;Chá vez et al, 2008). In fact, some well-established and long-used drugs were recently reported to prevent NF-kB activation (Muriel, 2009).…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effects of salvianolic acid B on CCl4-induced hepatic fibrosis through regulating NF-κB/IκBα signaling

Wang

Guo

et al. 2012

Journal of Ethnopharmacology

View full text Add to dashboard Cite

“…These observations indicate switching on of NF-κB signaling during HSC activation. Therefore, Bruck et al (2004) studied the effect of PDTC to prevent NF-κB activation in a model of fibrosis induced by chronic treatment with TAA in rats. They found that coadministration of PDTC to rats chronically treated with TAA inhibited the development of liver cirrhosis.…”

Section: Pyrrolidine Dithiocarbamate In Acute and Chronic Liver Damagementioning

confidence: 99%

NF‐κB in liver diseases: a target for drug therapy

Muriel

2008

J of Applied Toxicology

148

106

View full text Add to dashboard Cite

There are five nuclear factor-kB (NF-kB) transcription factors with important roles in innate immunity, liver inflammation, fibrosis and apoptosis prevention. Several inhibitors of NF-kB, like caffeic acid, captopril, curcumin, pyrrolidine dithiocarbamate, resveratrol, silymarin and thalidomide, have demonstrated antinecrotic, anticholestatic, antifibrotic and anticancer activities in the liver. A link between inflammation and hepatocellular carcinoma through the NF-kB pathway has been observed, providing ample experimental support for the tumor-promoting function of NF-kB in various models of cancer. NF-kB has been associated with the induction of proinflammatory gene expression and has attracted interest as a target for the treatment of inflammatory disease. However, despite much attention being focused on the deleterious effects of NF-kB, activation of this factor during the resolution of inflammation is associated with the production of antiinflammatory molecules like interleukin (IL)-10 and the onset of apoptosis. This suggests that NF-kB has an antiinflammatory role in vivo involving the regulation of the resolution of inflammation. Also, NF-kB promotes liver regeneration by upregulating IL-6 and other molecules like hepatocyte growth factor. It has been postulated that the beneficial properties of NF-kB are due to p50 homodimers, whose activation prevents cholestatic and chronic liver injury. More basic understanding on the function of the diverse NF-kB factors is urgently needed in different physiological and pathological conditions, because depending on the subunit composition of the dimmer, the disease and the stage of the illness, inhibition of the factor may result in a beneficial or in a deleterious response. Copyright © 2008 John Wiley & Sons, Ltd.There are five nuclear factor-kB (NF-kB) transcription factors with important roles in innate immunity, liver inflammation, fibrosis, and apoptosis prevention. Several inhibitors of NF-kB have demonstrated antinecrotic, anticholestatic, antifibrotic and anticancer activities in the

show abstract

A protective effect of pyrrolidine dithiocarbamate in a rat model of liver cirrhosis

Abstract: PDTC inhibits the development of liver cirrhosis in TAA-treated rats. The mechanism of action is associated with decreased oxidative stress and hepatic necroinflammation.

Cited by 41 publications

References 60 publications

Pyrrolidine Dithiocarbamate Inhibits Interleukin-6 Signaling through Impaired STAT3 Activation and Association with Transcriptional Coactivators in Hepatocytes

Pyrrolidine Dithiocarbamate Inhibits Interleukin-6 Signaling through Impaired STAT3 Activation and Association with Transcriptional Coactivators in Hepatocytes

Inhibitory effects of salvianolic acid B on CCl4-induced hepatic fibrosis through regulating NF-κB/IκBα signaling

NF‐κB in liver diseases: a target for drug therapy

Contact Info

Product

Resources

About