2015
DOI: 10.1136/lupus-2015-000123
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A proteinuria cut-off level of 0.7 g/day after 12 months of treatment best predicts long-term renal outcome in lupus nephritis: data from theMAINTAIN Nephritis Trial

Abstract: BackgroundAlthough an early decrease in proteinuria has been correlated with good long-term renal outcome in lupus nephritis (LN), studies aimed at defining a cut-off proteinuria value are missing, except a recent analysis performed on patients randomised in the Euro-Lupus Nephritis Trial, demonstrating that a target value of 0.8 g/day at month 12 optimised sensitivity and specificity for the prediction of good renal outcome. The objective of the current work is to validate this target in another LN study, nam… Show more

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Cited by 180 publications
(150 citation statements)
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“…In this research most of LN patients were females (1,8,10) and male sex was a risk factor of the late proteinuria recovery (7). Grade IV had the highest frequency among patients in this study which is similar to other Iranian studied (9, 11).…”
Section: Discussionsupporting
confidence: 87%
“…In this research most of LN patients were females (1,8,10) and male sex was a risk factor of the late proteinuria recovery (7). Grade IV had the highest frequency among patients in this study which is similar to other Iranian studied (9, 11).…”
Section: Discussionsupporting
confidence: 87%
“…This information could be useful when discussing prognosis with patients. Additionally, a proteinuria level of 0.7–0.8 gm/day after 12 months of treatment was recently identified as the best predictor of long‐term kidney survival compared to serum creatinine and urinary RBC status in a post hoc analysis of the Euro‐Lupus Nephritis Trial and MAINTAIN LN trials . These results were verified in an independent, ethnically diverse LN cohort .…”
Section: Discussionmentioning
confidence: 75%
“…The LUNAR trial's composite primary end point included the former criteria in addition to an inactive urinary sediment (fewer than five red blood cells per high-power field). For these analyses, urinary sediment was not included in the definition of complete response because of missing measurements and recent data demonstrating that sediment is not a useful predictor of long-term kidney outcomes (24,25). Inclusion of urinary sediment did not qualitatively affect the results presented here (see Supplemental Table 1).…”
Section: Study End Pointsmentioning
confidence: 99%