A proteomic atlas of ligand–receptor interactions at the ovine maternal–fetal interface reveals the role of histone lactylation in uterine remodeling

Yang, Qianying; Liu, Juan; Wang, Yue; Zhao, Wei; Wang, Wenjing; Cui, Jian; Yang, Jiajun; Yue, Yuan; Zhang, Shuai; Chu, Meiqiang; Lyu, Qingji; Ma, Lizhu; Tang, Yawen; Hu, Yupei; Kai, Masahiro; Zhao, Haichao; Tian, Jianhui; An, Liguo

doi:10.1016/j.jbc.2021.101456

Cited by 33 publications

(30 citation statements)

References 119 publications

(162 reference statements)

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“…Lactic acid is an important metabolite produced by glycolysis pathway. Recent studies have found that it functions as both a metabolite and a signaling molecule that participates in various physiological and pathological processes [24][25][26][27]. In 2019, it was revealed that lactic acid plays a role in tumor metabolism, immunity, and other biological functions, by mediating lactate modification of proteins and regulating gene expression [12].…”

Section: Discussionmentioning

confidence: 99%

Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma

et al. 2023

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Hepatocellular carcinoma (HCC), the most common type of primary liver cancer, often metastasizes to the lungs. The implications of lysine lactylation (Kla), a recently identified histone post-translational modification (PTM), in the pathology of HCC remain unclear. Here, we report the first proteomic survey of this specific modification in HCC (with no metastasis during 3 years of follow-up), normal liver tissues, and lung metastasis samples of HCC. Of the 2045 modification sites detected on 960 proteins, 1438 sites on 772 proteins contained quantitative information. Subsequently, we analyzed the differentially modified proteins among the different groups. Differentially lactylated proteins were found to be involved in several biological processes, includingbut not limited to-amino acid metabolism, ribosomal protein synthesis, and fatty acid metabolism. In addition, we identified numerous highly valuable lactate-modified proteins from the literature. Among them, we verified the lactate modification levels of the following two tumor-related proteins and obtained similar results: USP14 and ABCF1. These two modified proteins will be further investigated in our future studies. This paper is the first report on the lactylome of HCC and it provides a reliable foundation for further research on Kla in HCC.

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Section: Discussionmentioning

confidence: 99%

Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma

et al. 2023

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“…Lactylation is one of the most important ways to exert its biological functions of lactate, and is involved in a series of vital life processes, such as oncogenesis [ 93 ], embryonic development [ 94 ], uterine remodeling [ 95 ], immune disorders [ 96 ], macrophage polarization [ 97 ] and metabolic regulation. To date, only a limited number of studies have examined the role of histone lactylation in regulating central nervous system.…”

Section: The Potential Mechanisms Of Lactate-mediated Exercise-induce...mentioning

confidence: 99%

Section: Histone Lactylation: Could This Be the Future Of Exercise Pr...mentioning

confidence: 99%

The potential mechanisms of lactate in mediating exercise-enhanced cognitive function: a dual role as an energy supply substrate and a signaling molecule

Xue

Liu

et al. 2022

Nutr Metab (Lond)

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Lactate has previously been considered a metabolic waste and is mainly involved in exercise-induced fatigue. However, recent studies have found that lactate may be a mediator of the beneficial effects of exercise on brain health. Lactate plays a dual role as an energy supply substrate and a signaling molecule in this process. On the one hand, astrocytes can uptake circulating glucose or degrade glycogen for glycolysis to produce lactate, which is released into the extracellular space. Neurons can uptake extracellular lactate as an important supplement to their energy metabolism substrates, to meet the demand for large amounts of energy when synaptic activity is enhanced. Thus, synaptic activity and energy transfer show tight metabolic coupling. On the other hand, lactate acts as a signaling molecule to activate downstream signaling transduction pathways by specific receptors, inducing the expression of immediate early genes and cerebral angiogenesis. Moderate to high-intensity exercise not only increases lactate production and accumulation in muscle and blood but also promotes the uptake of skeletal muscle-derived lactate by the brain and enhances aerobic glycolysis to increase brain-derived lactate production. Furthermore, exercise regulates the expression or activity of transporters and enzymes involved in the astrocyte-neuron lactate shuttle to maintain the efficiency of this process; exercise also activates lactate receptor HCAR1, thus affecting brain plasticity. Rethinking the role of lactate in cognitive function and the regulatory effect of exercise is the main focus and highlights of the review. This may enrich the theoretical basis of lactate-related to promote brain health during exercise, and provide new perspectives for promoting a healthy aging strategy.

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“…Recently, it has also been claimed that lactylation affects embryogenesis. Yang et al discovered that H3K18la, which is a reflection of histone lactylation in the endometrium, participated in remodeling uterine receptivity ( Yang et al, 2022b ). This finding provided a novel insight for developing potential clinical intervention strategies to increase pregnancy rates following both natural and assisted conception.…”

Section: Lactylation and Diseasesmentioning

confidence: 99%

The role and mechanism of histone lactylation in health and diseases

Xie

Liu

et al. 2022

Front. Genet.

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Whether under anaerobic or aerobic conditions, glycolysis results in production of lactate. Increasing evidence suggests that lactate serves as a multifunctional signaling molecule that develops non-metabolic activities in addition to serving as a key metabolite to link glycolysis and oxidative phosphorylation. Histone posttranslational modification patterns (HPTMs) are essential epigenetic processes controlling a variety of biological activities. Proteomics based on mass spectrometry (MS) has been used to progressively reveal new HPTMs. Recent discoveries of histone lactylation modification mediated by lactate and subsequent research demonstrating its involvement in cancer, inflammation, lung fibrosis, and other conditions suggest that it plays a significant role in immune regulation and homeostasis maintenance. This review provides a brief overview of the complicated control of histone lactylation modification in both pathological and physiological conditions.

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A proteomic atlas of ligand–receptor interactions at the ovine maternal–fetal interface reveals the role of histone lactylation in uterine remodeling

Cited by 33 publications

References 119 publications

Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma

Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma

The potential mechanisms of lactate in mediating exercise-enhanced cognitive function: a dual role as an energy supply substrate and a signaling molecule

The role and mechanism of histone lactylation in health and diseases

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