2024
DOI: 10.1101/2024.06.26.24309530
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A proteomic signature of healthspan

Chia-Ling Kuo,
Peiran Liu,
Zhiduo Chen
et al.

Abstract: The focus of aging research has shifted from increasing lifespan to enhancing healthspan to reduce the time spent living with disability. Despite significant efforts to develop biomarkers of aging, few studies have focused on biomarkers of healthspan. We developed a proteomics-based signature of healthspan (healthspan proteomic score (HPS)) using data from the UK Biobank Pharma Proteomics Project (53,018 individuals and 2920 proteins). A lower HPS was associated with higher mortality risk and several age-relat… Show more

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