A proteomic view of cellular responses of macrophages to copper when added as ion or as copper-polyacrylate complex

Dalzon, Bastien; Devcic, Julie; Bons, Joanna; Torres, Anaëlle; Diemer, Hélène; Ravanel, Stéphane; Collin-Faure, Véronique; Cianférani, Sarah; Carapito, Christine; Rabilloud, Thierry

doi:10.1016/j.jprot.2021.104178

Cited by 1 publication

(1 citation statement)

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“…At present, on a global scale, the copper content in drinking water in China and Japan shall not exceed 1.0 mg l −1 , no more than 1.3 mg l −1 in the United States, and the European Union limits its content to 2.0 mg l −1 [11][12][13]. And when excessive copper accumulated in our body, copper ions will accumulate in the liver and affect DNA replication and the synthesis of many biological processes, pose a great threat to human health [14]. Therefore, it is necessary to develop a sensitive detector of copper ions.…”

Section: Introductionmentioning

confidence: 99%

Dual-emission fluorescent nanoprobe based on Ag nanoclusters for sensitive detection of Cu(II)

Chen

Bai

et al. 2022

Nanotechnology

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Noble metal nanoclusters have attracted much attention because of their excellent fluorescence properties. In this work, we demonstrated a dual-emission fluorescent nanocomposite based on silver nanoclusters. First, we synthesized positively charged His-AgNCs, which emits intense blue light, and then Ag nanoclusters with stable red emission were synthesized using DHLA as the ligand. Thus a dual-emission fluorescent nanoprobe was successfully obtained through electrostatic self-assembly, with the advantages of good water solubility, excellent stability and low toxicity. Based on the intensity ratio of the two emission peaks, the nanoprobe can be used for selective and sensitive detection of copper ions, and presents a good linear relationship within a certain concentration range. In addition, we also designed a polymer film, and our dual-emission nanoprobe was successfully loaded onto it, which means that the visual detection of copper ions is possible. This indicates that our dual-emission fluorescent nanoprobe has potential application prospects in environmental analysis, medical diagnosis, biological detection,etc.

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