A Protocol for a Systematic Review and Meta-Analysis of Hospital Readmissions Following Acute Upper Gastrointestinal Bleeding

Kaur, Sandeep; Dunne, Cody; Bresee, Lauren

doi:10.7759/cureus.19263

Cited by 1 publication

(8 citation statements)

References 14 publications

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“…9 The systematic review was registered with PROSPERO (CRD42021286951), and a priori protocol was previously published. 10 Table 1 outlines the PECOD (Population-Exposure-Comparator-Outcomes-Design) framework that the systematic review followed.…”

Section: Methodsmentioning

confidence: 99%

“…Researchers followed a predetermined, standardized screening tool for inclusion and exclusion. 10 For abstract screening, if data were not available to decide on inclusion, the article was forwarded to full-text review. In the full-text review stage, all inclusion criteria were met for the study to proceed to data extraction.…”

Section: Methodsmentioning

confidence: 99%

“…A standardized data extraction template was published a priori, which focused on four themes: study characteristics, patient characteristics, outcomes, and quality assessment. 10 Data analysis. Study characteristics were summarized using descriptive statistics.…”

Section: Methodsmentioning

confidence: 99%

“…etiology of UGIB). 10 Data analysis was performed using STATA. 11 In six circumstances, data from one study overlapped with another (e.g.…”

Section: Methodsmentioning

confidence: 99%

“…This review was completed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta‐analysis (PRISMA) 2020 guidelines 9 . The systematic review was registered with PROSPERO (CRD42021286951), and a priori protocol was previously published 10 . Table 1 outlines the PECOD (Population‐Exposure‐Comparator‐Outcomes‐Design) framework that the systematic review followed.…”

Section: Methodsmentioning

confidence: 99%

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30‐day readmission rates among upper gastrointestinal bleeds: A systematic review and meta‐analysis

Dunne

Kaur

Delacruz

et al. 2023

J of Gastro and Hepatol

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Background and Aim: Upper gastrointestinal bleeding (UGIB) is a common emergency, with high rates of hospitalization and in-patient mortality compared to other gastrointestinal diseases. Despite readmission rates being a common quality metric, little data are available for UGIBs. This study aimed to determine readmission rates for patients discharged following an UGIB. Methods: Adhering to PRISMA guidelines, MEDLINE, Embase, CENTRAL, and Web of Science were searched to October 16, 2021. Randomized and non-randomized studies that reported hospital readmission for patients following an UGIB were included. Abstract screening, data extraction, and quality assessment were conducted in duplicate. A random-effects meta-analysis was performed, with statistical heterogeneity measured using I 2 . The GRADE framework, with a modified Downs and Black tool, was used to determine certainty of evidence. Results: Seventy studies were included of 1847 screened abstracted, with moderate interrater reliability. Within these studies, 4 292 714 patients were analyzed with a mean age of 66.6 years, and 54.7% male. UGIB had a 30-day all-cause readmission rate of 17.4% (95% confidence interval [CI] 16.7-18.2%), stratification revealed a higher rate for variceal UGIB [19.6% (95% CI 17.6-21.5%)] than non-variceal [16.8% (95% CI 16.0-17.5%)]. Only one third were readmitted due to recurrent UGIB (4.8% [95% CI 3.1-6.4%]). UGIB due to peptic ulcer bleeding had the lowest 30-day readmission rate [6.9% (95% CI 3.8-10.0%)]. Certainty of evidence was low or very low for all outcomes. Conclusions: Almost one in five patients discharged after an UGIB are readmitted within 30 days. These data should prompt clinicians to reflect on their own practice to identify areas of strength or improvement.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…etiology of UGIB). 10 Data analysis was performed using STATA. 11 In six circumstances, data from one study overlapped with another (e.g.…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%