A Protocol for Conventional Sleep Deprivation Methods in Rats

Mahmoudi, Javad; Ahmadian, Nahid; Farajdokht, Fereshteh; Majdi, Alireza

doi:10.13183/jecns.v4i1.61

Cited by 3 publications

(2 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It seems that increasing the duration and improving the quality of sleep can slow down the progression of the disease. However, given the extensive study of animals in this field (Mahmoudi, Ahmadian, Farajdokht, Majdi, & Erfani, 2017), most results are derived from animal studies and human clinical studies are required to confirm the obtained results.…”

Section: Resultsmentioning

confidence: 99%

Review Paper: Tau Pathology of Alzheimer Disease: Possible Role of Sleep Deprivation

Ahmadian

Hejazi

Mahmoudi

et al. 2018

Basic Clin. Neurosci. J.

View full text Add to dashboard Cite

Sleep deprivation is a common complaint in modern societies. Insufficient sleep has increased the risk of catching neurodegenerative diseases such as Alzheimer’s. Several studies have indicated that restricted sleep increases the level of deposition of β-amyloid and formation of neurofibrillary tangles, the major brain microstructural hallmarks for Alzheimer disease. The mechanisms by which sleep deprivation affects the pathology of Alzheimer disease has not yet been fully and definitively identified. However, risk factors like apolipoprotein E risk alleles, kinases and phosphatases dysregulation, reactive oxygen species, endoplasmic reticulum damages, glymphatic system dysfunctions and orexinergic system inefficacy have been identified as the most important factors which mediates between the two conditions. In this review, these factors are briefly discussed.

show abstract

Section: Resultsmentioning

confidence: 99%

Review Paper: Tau Pathology of Alzheimer Disease: Possible Role of Sleep Deprivation

Ahmadian

Hejazi

Mahmoudi

et al. 2018

Basic Clin. Neurosci. J.

View full text Add to dashboard Cite

show abstract

“…It is also likely that misfolded hyperphosphorylated tau protein leads to neuron loss which could also affect sleep. It has been shown that people with dementia are awake for longer periods of time and often stay awake during the night [43]. In a report by McCullough et al, older healthy people were determined to have increased levels of tau tangles as measured by positron emission tomography scans and were reported to have less slow-wave and deep sleep [44].…”

Section: Discussionmentioning

confidence: 99%

What is the Relationship Between Sleep and Alzheimer’s Disease? A Narrative Review

Gobraeil

Rizq

2022

URNCST Journal

View full text Add to dashboard Cite

Introduction: Alzheimer’s disease (AD) is the most common neurodegenerative disorder, impacting 55 million people worldwide. With rates on the rise, research is continually being conducted to examine risk factors that are contributing to its growing prevalence. There is growing evidence showing a bidirectional relationship between sleep and AD, where poor sleep contributes to the development of AD, and conversely, AD pathology impairs patients’ sleep quality and quantity. Methods: A narrative review was conducted in a systematic fashion using the databases PubMed, Embase and the Cochrane Library. After performing a literature search, high-quality relevant sources are selected, and data were extracted and analyzed to explore the relationship between AD and lack of sleep. Results: A bi-directional relationship was suggested based off evidence which was gathered from longitudinal studies and cross-sectional studies. As well as experimental studies which was focused on the mechanisms of AD, including tau protein aggregation and beta-amyloid accumulation. Discussion: Results showed that there could be a potential bi-directional relationship when discussing AD and sleep. In AD, metabolic waste known as beta-amyloid creates neurotoxic plaques which form in the spaces between neurons. Studies suggest that Aβ has an important role to play in sleep as increased sleep disturbances are present with Aβ accumulation. Conversely, after losing one night of sleep, there is an increase in beta-amyloid, highlighting the role of sleep in metabolite clearance. Another AD protein associated with sleep is tau. Poor sleep is associated with clumping of tau, forming toxic tangles inside neurons which injure tissues nearby and contributes to cognitive impairment. However, it still difficult to conclude the directionality of sleep and AD due to limitations on the current technologies used to detect amyloid-beta and tau. Conclusion: This narrative review concludes that a bi-directional relationship may be present between sleep abnormalities and AD. Management of poor sleep quality should be further considered as a potential prophylactic intervention against AD.

show abstract

Pretreatment with combined low-level laser therapy and methylene blue improves learning and memory in sleep-deprived mice

2022

View full text Add to dashboard Cite

A Protocol for Conventional Sleep Deprivation Methods in Rats

Cited by 3 publications

References 25 publications

Review Paper: Tau Pathology of Alzheimer Disease: Possible Role of Sleep Deprivation

Review Paper: Tau Pathology of Alzheimer Disease: Possible Role of Sleep Deprivation

What is the Relationship Between Sleep and Alzheimer’s Disease? A Narrative Review

Pretreatment with combined low-level laser therapy and methylene blue improves learning and memory in sleep-deprived mice

Contact Info

Product

Resources

About