A protocol format for the preparation, registration and publication of systematic reviews of animal intervention studies

Vries, Rob B. M. de; Hooijmans, Carlijn R.; Langendam, Miranda; Luijk, Judith van; Leenaars, Marlies; Ritskes‐Hoitinga, Merel; Wever, Kimberley E.

doi:10.1002/ebm2.7

Cited by 230 publications

(180 citation statements)

References 23 publications

Supporting

Mentioning

179

Contrasting

Order By: Relevance

“…The protocol for this systematic review was pre‐defined using the SYRCLE guidelines (de Vries et al . ) and published on http://www.radboudumc.nl/en/research/radboud-technology-centers/animal-research-facility/systematic-review-center-for-laboratory-animal-experimentation/protocols on 5th December 2017 prior to completion of primary screening. Post‐publication modifications were made to the protocol as follows: (i) At the primary‐screening phase, discrepancies on decision to include were resolved by Tristan R Hollyer (TRH) and Birgitte S Kousholt (BSK).…”

Section: Methodsmentioning

confidence: 99%

“…The protocol for this systematic review was pre-defined using the SYRCLE guidelines (de Vries et al 2015) and published on www. radboudumc.nl/en/research/radboud-technology-centers/animal-rese arch-facility/systematic-review-center-for-laboratory-animal-experim entation/protocols on 5th December 2017 prior to completion of primary screening.…”

Section: Review Protocol and Amendmentsmentioning

confidence: 99%

See 1 more Smart Citation

The evidence for the physiological effects of lactate on the cerebral microcirculation: a systematic review

Hollyer

Bordoni

Kousholt

et al. 2019

Journal of Neurochemistry

View full text Add to dashboard Cite

Lactate's role in the brain is understood as a contributor to brain energy metabolism, but it may also regulate the cerebral microcirculation. The purpose of this systematic review was to evaluate evidence of lactate as a physiological effector within the normal cerebral microcirculation in reports ranging from in vitro experiments to in vivo studies in animals and humans. Following pre‐registration of a review protocol, we systematically searched the PubMed, EMBASE , and Cochrane databases for literature covering themes of ‘lactate’, ‘the brain’, and ‘microcirculation’. Abstracts were screened, and data extracted independently by two individuals. We excluded studies evaluating lactate in disease models. Twenty‐eight papers were identified, 18 of which were in vivo animal experiments (65%), four on human studies (14%), and six on in vitro or ex vivo experiments (21%). Approximately half of the papers identified lactate as an augmenter of the hyperemic response to functional activation by a visual stimulus or as an instigator of hyperemia in a dose‐dependent manner, without external stimulation. The mechanisms are likely to be coupled to NAD + / NADH redox state influencing the production of nitric oxide. Unfortunately, only 38% of these studies demonstrated any control for bias, which makes reliable generalizations of the conclusions insecure. This systematic review identifies that lactate may act as a dose‐dependent regulator of cerebral microcirculation by augmenting the hyperemic response to functional activation below 5 mmol/kg, and by initiating a hyperemic response above 5 mmol/kg. Open Science Badges This article has received a badge for * Pre‐registration * because it made the data publicly available. The data can be accessed at www.radboudumc.nl/getmedia/53625326-d1df-432c-980f-27c7c80d1a90/THollyer_lactate_protocol.aspx . The complete Open Science Disclosure form for this article can be found at the end of the article. More information about the Open Practices badges can be found at https://cos.io/our-services/open-science-badges/ .

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Review Protocol and Amendmentsmentioning

confidence: 99%

The evidence for the physiological effects of lactate on the cerebral microcirculation: a systematic review

Hollyer

Bordoni

Kousholt

et al. 2019

Journal of Neurochemistry

View full text Add to dashboard Cite

show abstract

“…We adhered to SYRCLE's guidelines (25) (26), and to the PRISMA (27) reporting checklist. To ease reading of the methodology, definitions of technical terms are provided in Supplemental Methods (S1.1).…”

Section: Methodsmentioning

confidence: 99%

The behavioral phenotype of early life adversity: a 3-level meta-analysis of preclinical studies

Bonapersona

Kentrop

Lissa

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…Three reviews (Segura-Egea et al 2016, Tib urcio-Machado et al 2017 were scored '0' for protocol registration. Developing a protocol for systematic review in advance helps the researchers to reflect prospectively on the proposed methodology, which reduces methodological flaws, bias and risk of duplication, and increases transparency and visibility to potential researchers (Straus & Moher 2010, de Vries et al 2015. Therefore, protocol development and registration is likely to benefit evidence-based practice.…”

Section: Quality Of the Individual Systematic Reviewsmentioning

confidence: 99%

Association between diabetes and the outcome of root canal treatment in adults: an umbrella review

et al. 2019

View full text Add to dashboard Cite

Background Diabetes mellitus is the most common metabolic disorder amongst dental patients. The association between the diabetes and the outcome of root canal treatment is unclear. Aim To conduct an umbrella review to determine whether there is an association between diabetes and the outcome of root canal treatment. Data source The protocol of the review was developed and registered in the PROSPERO database (CRD42019141684). Four electronic databases (PubMed, EBSCHOhost, Cochrane and Scopus databases) were used to perform a literature search until July 2019. Study eligibility criteria, participants and interventions Systematic reviews with or without meta‐analyses published in English assessing any outcomes of root canal treatment comparing diabetic and nondiabetic patients were included. Two reviewers were involved independently in study selection, data extraction and appraising the reviews that were included. Disagreements were resolved with the help of a third reviewer. Study appraisal and synthesis methods The quality of the reviews was assessed using the AMSTAR tool (A measurement tool to assess systematic reviews), with 11 items. Each AMSTAR item was given a score of 1 if the criterion was met, or 0 if the criterion was not met or the information was unclear. Results Four systematic reviews were included. The AMSTAR score for the reviews ranged from 5 to 7, out of a maximum score of 11, and all the systematic reviews were classified as ‘medium’ quality. Limitations Only two systematic reviews included a meta‐analysis. Only systematic reviews published in English were included. Conclusions and implications of key findings Diabetes mellitus is associated with the outcome of root canal treatment and can be considered as a preoperative prognostic factor.

show abstract

A protocol format for the preparation, registration and publication of systematic reviews of animal intervention studies

Cited by 230 publications

References 23 publications

The evidence for the physiological effects of lactate on the cerebral microcirculation: a systematic review

The evidence for the physiological effects of lactate on the cerebral microcirculation: a systematic review

The behavioral phenotype of early life adversity: a 3-level meta-analysis of preclinical studies

Association between diabetes and the outcome of root canal treatment in adults: an umbrella review

Contact Info

Product

Resources

About