A proton magnetic resonance spectroscopy study in schizoaffective disorder: Comparison of bipolar disorder and schziophrenia

Kalaycı, Demet; Özdel, Osman; Sözeri-Varma, Gülfizar; Kıroğlu, Yılmaz; Tümkaya, Selim

doi:10.1016/j.pnpbp.2012.01.010

Cited by 20 publications

(14 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…95 Findings were partially replicated by Kalayci and colleagues, who reported a universal decrease in left and right dorsolateral prefrontal cortex NAA/Cr across diagnostic groups, but a decrease in Cho/Cr only in BD and schizoaffective disorder, but not schizophrenia when compared to controls. 96 Anterior cingulate cortex metabolite measurements at 1.5 Tesla were suggestive of elevations of Cho/Cr in schizophrenia only without detectable abnormalities in NAA/Cr across groups. 97 However, because of a later report of decreased Cr levels in acutely ill patients with schizophrenia but not BD, it is unclear if findings are attributable to Cr alterations rather than Cho or NAA changes.…”

Section: Resultsmentioning

confidence: 93%

Brain structure, function, and neurochemistry in schizophrenia and bipolar disorder—a systematic review of the magnetic resonance neuroimaging literature

et al. 2017

View full text Add to dashboard Cite

Since Emil Kraepelin's conceptualization of endogenous psychoses as dementia praecox and manic depression, the separation between primary psychotic disorders and primary affective disorders has been much debated. We conducted a systematic review of case-control studies contrasting magnetic resonance imaging studies in schizophrenia and bipolar disorder. A literature search in PubMed of studies published between January 2005 and December 2016 was conducted, and 50 structural, 29 functional, 7 magnetic resonance spectroscopy, and 8 combined imaging and genetic studies were deemed eligible for systematic review. Structural neuroimaging studies suggest white matter integrity deficits that are consistent across the illnesses, while gray matter reductions appear more widespread in schizophrenia compared to bipolar disorder. Spectroscopy studies in cortical gray matter report evidence of decreased neuronal integrity in both disorders. Functional neuroimaging studies typically report similar functional architecture of brain networks in healthy controls and patients across the psychosis spectrum, but find differential extent of alterations in task related activation and resting state connectivity between illnesses. The very limited imaging-genetic literature suggests a relationship between psychosis risk genes and brain structure, and possible gene by diagnosis interaction effects on functional imaging markers. While the existing literature suggests some shared and some distinct neural markers in schizophrenia and bipolar disorder, it will be imperative to conduct large, well designed, multi-modal neuroimaging studies in medication-naïve first episode patients that will be followed longitudinally over the course of their illness in an effort to advance our understanding of disease mechanisms.

show abstract

Section: Resultsmentioning

confidence: 93%

Brain structure, function, and neurochemistry in schizophrenia and bipolar disorder—a systematic review of the magnetic resonance neuroimaging literature

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Molina et al (2007) found that males with BD had reduced NAA concentration in the right DLPFC (BA 8, 9, 10 and 46) while Kalayci et al (2012) reported NAA reductions in the DLPFC in subjects with BD, schizoaffective disorder, and schizophrenia. Similar findings have been reported in the pediatric BD literature, with both left and right hemispheres implicated (Chang et al, 2003;Sassi et al, 2005;Olvera et al, 2007).…”

Section: The Orbitofrontal Cortex (Ofc)mentioning

confidence: 99%

Neuropathological and neuromorphometric abnormalities in bipolar disorder: View from the medial prefrontal cortical network

Savitz

Price

Drevets

2014

Neuroscience & Biobehavioral Reviews

126

View full text Add to dashboard Cite

“…That could be best explained by the fact that this study focused on patients with schizophrenia, while the study in reference was comprised of type I bipolar disorder patients. The results could also be related to the affective basis of bipolar disorder 44. In addition, the NAA rise witnessed within the framework of the latter study is more likely to be attributed to the alleviation of manic symptoms than to the olanzapine-related therapeutic effects.…”

Section: Discussionmentioning

confidence: 68%

The effect of atypical antipsychotics on brain N-acetylaspartate levels in antipsychotic-naïve first-episode patients with schizophrenia: a preliminary study

Grošić¹,

Grošić²,

Kalember³

et al. 2014

NDT

View full text Add to dashboard Cite

PurposeTo investigate the correlates of a clinical therapeutic response by using the parameters measured by proton magnetic resonance spectroscopy after the administration of atypical antipsychotics.Patients and methodsTwenty-five antipsychotic-naïve first-episode patients with schizophrenia were monitored for 12 months. The patients were evaluated using 1H magnetic resonance spectroscopy in the dorsolateral prefrontal cortex and Positive and Negative Syndrome Scale, Clinical Global Impression Scale of Severity, Tower of London – Drexel University, Letter–Number Span Test, Trail Making Test A, and Personal and Social Performance Scale. They were administered atypical antipsychotics, starting with quetiapine. In the absence of a therapeutic response, another antipsychotic was introduced.ResultsAfter 12 study months, the N-acetylaspartate/creatine (NAA/Cr) level did not significantly change at the whole-group level. Additional analysis revealed a significant rise in the NAA/Cr level in the study group that stayed on the same antipsychotic throughout the study course (P=0.008) and a significant drop in NAA/Cr in the study group that switched antipsychotics (P=0.005). On the whole-group level, no significant correlations between NAA/Cr values and other scores were found at either baseline or after 12 study months.ConclusionOne-year treatment with atypical antipsychotics administered to antipsychotic-naïve patients didn’t result in a significant rise in the NAA/Cr ratio. However, a significant rise was witnessed in the study group in which a satisfactory therapeutic response had been achieved with a single antipsychotic administration.

show abstract

A proton magnetic resonance spectroscopy study in schizoaffective disorder: Comparison of bipolar disorder and schziophrenia

Cited by 20 publications

References 47 publications

Brain structure, function, and neurochemistry in schizophrenia and bipolar disorder—a systematic review of the magnetic resonance neuroimaging literature

Brain structure, function, and neurochemistry in schizophrenia and bipolar disorder—a systematic review of the magnetic resonance neuroimaging literature

Neuropathological and neuromorphometric abnormalities in bipolar disorder: View from the medial prefrontal cortical network

The effect of atypical antipsychotics on brain N-acetylaspartate levels in antipsychotic-naïve first-episode patients with schizophrenia: a preliminary study

Contact Info

Product

Resources

About

A proton magnetic resonance spectroscopy study in schizoaffective disorder: Comparison of bipolar disorder and schziophrenia

Cited by 20 publications

References 47 publications

Brain structure, function, and neurochemistry in schizophrenia and bipolar disorder—a systematic review of the magnetic resonance neuroimaging literature

Brain structure, function, and neurochemistry in schizophrenia and bipolar disorder—a systematic review of the magnetic resonance neuroimaging literature

Neuropathological and neuromorphometric abnormalities in bipolar disorder: View from the medial prefrontal cortical network

The effect of atypical antipsychotics on brain N-acetylaspartate levels in antipsychotic-na&iuml;ve first-episode patients with schizophrenia: a preliminary study

Contact Info

Product

Resources

About

The effect of atypical antipsychotics on brain N-acetylaspartate levels in antipsychotic-naïve first-episode patients with schizophrenia: a preliminary study