A prototypic mathematical model of the human hair cycle

Al-Nuaimi, Yusur; Goodfellow, Marc; Paus, Ralf; Baier, Gerold

doi:10.1016/j.jtbi.2012.05.027

Cited by 38 publications

(40 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Their model incorporates general aspects of hair cycle regulation, and shows qualitative agreement to experimental observations. Also recently, Al-Nuaimi et al developed a general model for hair cycling based on observations in the literature [10]. These authors derived a mathematical, kinetic model which proposed that negative feedback between dynamic MX keratinocytes and static DP cells could reproduce the cyclical growth patterns of the hair follicle.…”

Section: Introductionmentioning

confidence: 99%

Mouse Hair Cycle Expression Dynamics Modeled as Coupled Mesenchymal and Epithelial Oscillators

et al. 2014

View full text Add to dashboard Cite

The hair cycle is a dynamic process where follicles repeatedly move through phases of growth, retraction, and relative quiescence. This process is an example of temporal and spatial biological complexity. Understanding of the hair cycle and its regulation would shed light on many other complex systems relevant to biological and medical research. Currently, a systematic characterization of gene expression and summarization within the context of a mathematical model is not yet available. Given the cyclic nature of the hair cycle, we felt it was important to consider a subset of genes with periodic expression. To this end, we combined several mathematical approaches with high-throughput, whole mouse skin, mRNA expression data to characterize aspects of the dynamics and the possible cell populations corresponding to potentially periodic patterns. In particular two gene clusters, demonstrating properties of out-of-phase synchronized expression, were identified. A mean field, phase coupled oscillator model was shown to quantitatively recapitulate the synchronization observed in the data. Furthermore, we found only one configuration of positive-negative coupling to be dynamically stable, which provided insight on general features of the regulation. Subsequent bifurcation analysis was able to identify and describe alternate states based on perturbation of system parameters. A 2-population mixture model and cell type enrichment was used to associate the two gene clusters to features of background mesenchymal populations and rapidly expanding follicular epithelial cells. Distinct timing and localization of expression was also shown by RNA and protein imaging for representative genes. Taken together, the evidence suggests that synchronization between expanding epithelial and background mesenchymal cells may be maintained, in part, by inhibitory regulation, and potential mediators of this regulation were identified. Furthermore, the model suggests that impairing this negative regulation will drive a bifurcation which may represent transition into a pathological state such as hair miniaturization.

show abstract

Section: Introductionmentioning

confidence: 99%

Mouse Hair Cycle Expression Dynamics Modeled as Coupled Mesenchymal and Epithelial Oscillators

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Hair follicles are organs that constantly cycle throughout a person's life (Al-Nuaimi et al, 2012Paus and Cotsarelis, 1999;Millar, 2002). Alopecia areata disrupts this natural cycle, but it does not cause damage to hair follicles' structure, so affected follicles do not lose their capability to produce hair (Gilhar et al, 2012(Gilhar et al, , 2007.…”

Section: Alopecia Areata and Immune Privilegementioning

confidence: 99%

“…Alopecia areata disrupts this natural cycle, but it does not cause damage to hair follicles' structure, so affected follicles do not lose their capability to produce hair (Gilhar et al, 2012(Gilhar et al, , 2007. The hair follicle cycle has three stages: anagen, catagen, and telogen (Al-Nuaimi et al, 2012Paus and Cotsarelis, 1999). Anagen is the active growth phase during which pigmented hair is produced.…”

Section: Alopecia Areata and Immune Privilegementioning

confidence: 99%

“…Production of a new hair shaft commences at the end of telogen, and as this new fiber grows, the old one is pushed out of the hair canal and discarded (Al-Nuaimi et al, 2012Paus and Cotsarelis, 1999). The three cycle phases have different lengths on average: anagen lasts 2-5 years, catagen 3-6 weeks, and telogen 3-5 months (Al-Nuaimi et al, 2012;Bergfeld and Mulinari-Brenner, 2001). Almost always, hair follicles get affected by AA when they are in anagen.…”

Section: Alopecia Areata and Immune Privilegementioning

confidence: 99%

“…Genetic factors associated with AA have been explored through a computational model (Catanzaro et al, 2010), and the hair cycle has been simulated with a cellular automata model (Halloy et al, 2000(Halloy et al, , 2002 as well as ordinary differential equations (Al-Nuaimi et al, 2012) and stochastic differential equations (Murray et al, 2012). While these models capture important characteristics of the disease, namely, genetic predisposition, circular lesion pattern, and hair cycle disruption, they do not provide an insight into the interactions between hair follicles and the immune system.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Mathematical model for alopecia areata

Dobreva

Paus

Cogan

2015

Journal of Theoretical Biology

Self Cite

View full text Add to dashboard Cite

Mitochondrially localized MPZL3 emerges as a signaling hub of mammalian physiology

et al. 2021

Self Cite

View full text Add to dashboard Cite

MPZL3 is a nuclear‐encoded, mitochondrially localized, immunoglobulin‐like V‐type protein that functions as a key regulator of epithelial cell differentiation, lipid metabolism, ROS production, glycemic control, and energy expenditure. Recently, MPZL3 has surfaced as an important modulator of sebaceous gland function and of hair follicle cycling, an organ transformation process that is also governed by peripheral clock gene activity and PPARγ. Given the phenotype similarities and differences between Mpzl3 and Pparγ knockout mice, we propose that MPZL3 serves as a signaling hub that is regulated by core clock gene products and/or PPARγ to translate signals from these nuclear transcription factors to the mitochondria to modulate circadian and metabolic regulation. Conservation between murine and human MPZL3 suggests that human MPZL3 may have similarly complex functions in health and disease. We summarize current knowledge and discuss future directions to elucidate the full spectrum of MPZL3 functions in mammalian physiology.

show abstract

A prototypic mathematical model of the human hair cycle

Cited by 38 publications

References 73 publications

Mouse Hair Cycle Expression Dynamics Modeled as Coupled Mesenchymal and Epithelial Oscillators

Mouse Hair Cycle Expression Dynamics Modeled as Coupled Mesenchymal and Epithelial Oscillators

Mathematical model for alopecia areata

Mitochondrially localized MPZL3 emerges as a signaling hub of mammalian physiology

Contact Info

Product

Resources

About