2022
DOI: 10.9778/cmajo.20210093
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A province-wide HIV initiative to accelerate initiation of treatment-as-prevention and virologic suppression in British Columbia, Canada: a population-based cohort study

Abstract: T he personal and public health benefits of early initiation of antiretroviral treatment (ART) are well documented. [1][2][3][4][5] In addition to decreasing morbidity and mortality rates among people living with HIV/ AIDS, 1-3 ART has also been shown to reduce the incidence of HIV cases in a population. 4,5 This evidence led to the conception of HIV treatment as prevention (TasP), the scaling-up of testing followed by the immediate initiation of ART, as a strategy for reducing AIDS-related morbidity and death… Show more

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Cited by 6 publications
(4 citation statements)
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“…4 a). Between 2012 and approximately 2016, the percentage of detectable pVL test results declined from nearly 29% to an average of 16% as a result of a province-wide implementation of widespread HIV testing and immediate initiation of free-of-charge ART that began in 2013 [ 47 ]. Since 2016, the overall percentage of detectable pVL has remained relatively stable, though there was a slight uptick in the proportion of detectable pVL tests during 2020 because care providers were asked to reduce the frequency of routine pVL testing for PWH with long-term viremia suppression, to preserve laboratory capacity for COVID-19 diagnostic testing (which was also performed on the cobas 6800 in BC).…”
Section: Resultsmentioning
confidence: 99%
“…4 a). Between 2012 and approximately 2016, the percentage of detectable pVL test results declined from nearly 29% to an average of 16% as a result of a province-wide implementation of widespread HIV testing and immediate initiation of free-of-charge ART that began in 2013 [ 47 ]. Since 2016, the overall percentage of detectable pVL has remained relatively stable, though there was a slight uptick in the proportion of detectable pVL tests during 2020 because care providers were asked to reduce the frequency of routine pVL testing for PWH with long-term viremia suppression, to preserve laboratory capacity for COVID-19 diagnostic testing (which was also performed on the cobas 6800 in BC).…”
Section: Resultsmentioning
confidence: 99%
“…4a ). Between 2012 and approximately 2016, the percentage of detectable pVL test results declined from nearly 29% to an average of 16% as a result of a province-wide implementation of widespread HIV testing and immediate initiation of free-of-charge ART that began in 2013 [41]. Since 2016, the overall percentage of detectable pVL has remained relatively stable, though there was a slight uptick in the proportion of detectable pVL tests during 2020 because care providers were asked to reduce the frequency of routine pVL testing for PWH with long-term viremia suppression, to preserve lab capacity for COVID-19 diagnostic testing (which was also performed on the cobas 6800 in BC).…”
Section: Resultsmentioning
confidence: 99%
“…Furthermore, differences in the use and measurement of ART and other exposures across studies are important considerations; for instance, the timing of ART initiation following diagnosis of HIV is an important variable for understanding and assessing the risk of transmission. 37,38 In addition, demonstration of viral linkage is important information that can supplement self-reported data describing sexual and other risk behaviours, providing confirmatory evidence for observed seroconversions that have occurred between the sex partners under study (as opposed to those having occurred from another source).…”
Section: Conclusion and Implications For Decision-or Policy-makingmentioning
confidence: 99%