Abstract. In the present paper, we investigate a modified pseudo-rigid-body (MPRB) modeling approach for compliant mechanisms with fixed-guided beam flexures by considering the nonlinear effects of center-shifting and load-stiffening. In particular, a fixed-guided compliant beam is modeled as a pair of fixed-free compliant beams jointed at the inflection point, where each fixed-free beam flexure is further modeled by a rigid link connected with an extension spring by a torsion spring, based on the beam constraint model (BCM). Meanwhile, the characteristic parameters of the proposed MPRB model are no longer constant values, but affected by the applied general tip load, especially the axial force. The developed MPRB modeling method is then applied to the analysis of three common compliant mechanisms (i.e. compound parallelogram mechanisms, bistable mechanisms and 1-DOF translational mechanisms), which is further verified by the finite element analysis (FEA) results. The proposed MPRB model provides a more accurate method to predict the performance characteristics such as deformation capability, stiffness variation, as well as error motions of complaint mechanisms with fixed-guided beam flexures, and offers a new look into the design and optimization of beam-based compliant mechanisms.