A pseudo three-zone simulated moving bed with solvent gradient for quaternary separations

Jiang, Chongwen; Feng-mei, Huang; Feng, Wei

doi:10.1016/j.chroma.2014.02.010

Cited by 8 publications

(6 citation statements)

References 20 publications

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“…The nine-zone SMB can be regarded as a five-zone SMB in parallel with the conventional four-zone SMB, and the whole system forms two closed loops with bypass stream. In Wooley et al's work [56], a nine-zone SMB was applied to extract two sugars from the biohydrolysis product with a purity close to 100% and a recovery of 88%.…”

Section: Smbs With More Than Four Zonesmentioning

confidence: 99%

Research Progress on the Typical Variants of Simulated Moving Bed: From the Established Processes to the Advanced Technologies

et al. 2023

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Simulated moving bed (SMB) chromatography is a highly efficient adsorption-based separation technology with various industrial applications. At present, its application has been successfully extended to the biochemical and pharmaceutical industrial sectors. SMB possesses the advantages of high product purity and yield, large feed treatment capacity, and simple process control due to the continuous operation mode and the efficient separation mechanism, particularly for difficult separation. Moreover, SMB performs well, particularly for multi-component separation or complicated systems’ purification processes in which each component exhibits similar properties and low resolution. With the development of the economy and technology, SMB technology needs to be improved and optimized to enhance its performance and deal with more complex separation tasks. This paper summarizes the typical variants or modifications of the SMB process through three aspects: zone variant, gradient variant, and feed or operation variant. The corresponding modification principles, operating modes, advantages, limitations, and practical application areas of each variant were comprehensively investigated. Finally, the application prospect and development direction were summarized, which could provide valuable recommendations and guidance for future research in the SMB area.

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Section: Smbs With More Than Four Zonesmentioning

confidence: 99%

Research Progress on the Typical Variants of Simulated Moving Bed: From the Established Processes to the Advanced Technologies

et al. 2023

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“…However, their work did not refer to the separation of four compounds. 30,31 As a series of important genetic information carriers, 5 0 -ribonucleotides, including adenosine 5 0 -monophosphate (AMP), cytidine 5 0 -monophosphate (CMP), guanosine 5 0 -monophosphate (GMP), and uridine 5 0 -monophosphate (UMP), are mainly derived from the enzymatic hydrolysis of RNA and then separated by a cation exchange resin in the production. 32 Because of the similar physicochemical properties of the four 5 0 -ribonucleotides, the interaction mechanism between these components and cation exchange resins is complicated.…”

Section: Simulated Moving Bed (Smb) Was Developed Originally By Unive...mentioning

confidence: 99%

“…However, they did not demonstrate the feasibility of those operating modes through experiments. Jiang et al 31 developed a pseudo‐three‐zone SMB to recovery capsaicin and dihydrocapsaicin from capsaicin raw materials (four‐component system) by means of gradient elution operation. However, their work did not refer to the separation of four compounds 30,31 …”

Section: Introductionmentioning

confidence: 99%

Design and optimization of JO‐IEX process for highly efficient quaternary separation of 5′‐ribonucleotides

et al. 2022

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The developed JO‐IEX technology was applied to continuously separate four 5′‐ribonucleotides here. The unit contained seven columns with three separation steps, among which three columns were for the quaternary separation and the others for regeneration of resins. The operating conditions, that is, the critical flow rates in three separation steps were preliminarily designed according to the equilibrium theory and optimized by a three‐dimensional theoretical separation region approach. The feasibility of the JO‐IEX process and the separation performances were validated by four runs using the actual 5′‐ribonucleotides' enzymatic hydrolysate as feed solutions. The purities and yields of 5′‐ribonucleotides could reach above 97%. The productivity was enhanced to be 0.91 g/(kg h), and the desorbent consumption was reduced to be 1.01 L/g, compared to those of 0.70 g/(kg h) and 1.75 L/g in the fixed‐bed process. The technology proposed could be a potential technique in the continuous multicomponent ion‐exchange separation process.

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“…However, gradient elution has been developed and designed with simple binary or ternary model mixtures , , . The application of a pseudo three‐zone SMB with gradient operation has been reported to separate quaternary mixtures obtained after pretreatment of capsicum oleoresin . In this work, the authors used two‐zone open‐loop SMB with one additional isolated regeneration zone.…”

Section: Operating Strategies To Extend the Potential Of Conventionalmentioning

confidence: 99%

“…Since the first gradient application in conventional four-zone SMB chromatography was described [97], many different types of gradient operations have been proposed. These include SMB processes involving supercritical mobile phases [98][99][100][101][102][103][104][105], solvent composition modulations [24,25,[106][107][108][109][110][111][112][113][114][115], and temperature gradients [116]. In practice, not many gradient SMB processes are practically applied because of the difficulty in precisely controlling the travelling gradient profiles.…”

Section: Altering the Elution Strength In Smb Chromatographymentioning

confidence: 99%

Advanced Operating Strategies to Extend the Applications of Simulated Moving Bed Chromatography

et al. 2017

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Chromatographic separation with solid stationary and fluid mobile phases is widely used to isolate and purify compounds. One of the most productive improvements in preparative chromatography is the simulated moving bed (SMB) process, which enables continuous feed supply and product removal by periodic operation of a multicolumn to simulate a countercurrent flow between the phases. The SMB process produces high‐purity compounds, even with low selectivity, and offers higher productivity and lower eluent consumption than batch chromatography. Recently, intensive efforts have been made to expand the range of applications through the design, modeling, and optimization of the SMB process to produce advanced operating strategies, which are described and evaluated in this review.

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A pseudo three-zone simulated moving bed with solvent gradient for quaternary separations

Cited by 8 publications

References 20 publications

Research Progress on the Typical Variants of Simulated Moving Bed: From the Established Processes to the Advanced Technologies

Research Progress on the Typical Variants of Simulated Moving Bed: From the Established Processes to the Advanced Technologies

Design and optimization of JO‐IEX process for highly efficient quaternary separation of 5′‐ribonucleotides

Advanced Operating Strategies to Extend the Applications of Simulated Moving Bed Chromatography

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