A Psychiatric Day Care Service in Zambia

Dhadphale, M; Shaikh, Shahida

doi:10.1192/pb.5.2.23

Cited by 1 publication

(1 citation statement)

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“…Nevertheless, in recent years the khat habit has made its appearance in regions far from the areas of cultivation of the plant, and this is mainly due to the possibility of air-transporting the leaves. Thus, fresh khat is now marketed in Great Britain (Mayberry et al, 1984;McLaren, 1987), which is of concern because the consumption of this drug may result in toxic psychosis (Carothers, 1945;Dhadphale et al, 1981), and because its habitual use is characterized by moderate but often persistent psychic dependence (Eddy et al, 1965). Indeed, cases of khatinduced psychosis have now also been observed in Great Britain (Critchlow & Seifert, 1987;Gough & Cookson, 1984;McLaren, 1987;Pantelis et al, 1989) as well as in the United States (Giannini & Castellani, 1982).…”

Section: Introductionmentioning

confidence: 99%

Amphetamine‐like effects in humans of the khat alkaloid cathinone.

Brenneisen

Fisch

Koelbing

et al. 1990

Brit J Clinical Pharma

231

140

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1 The chewing of khat leaves as a stimulant is common in certain countries, and the effects of this material are supposed to be due to the phenylalkylamine alkaloid cathinone. In order to determine the effects of this substance in humans, a single oral dose of cathinone or placebo was administered to six healthy male volunteers in a double-blind, random order crossover study. 2 Cathinone produced increases in blood pressure and in heart rate, and these changes were concomitant with the presence of cathinone in blood plasma. 3 The physical and mental changes that the subjects reported during the experiment indicated that cathinone has in humans euphorigenic and psychostimulant effects. 4 These observations support the assumption that cathinone is the constituent mainly responsible for the effects of khat, and they show that this alkaloid has also in humans amphetamine-like effects.

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