A psychophysiological hypothesis on the aetiology of duodenal ulceration

Levin, Alexandra; Katzeff, I.E.; Schlebusch, Lourens; Moshal, M G; Schlemmer, Lawrence; Goolam-Hoosen, I.; Naidoo, Nitalia

doi:10.1016/0306-9877(80)90050-x

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…Acid secretion is, in part, modulated by opposing inputs from the autonomic nervous system: a stimulatory‐parasympathetic component and an inhibitory‐sympathetic component. Increased parasympathetic activity (vagal) has been implicated in the etiology of gastric and duodenal ulcers 17,53 . Moreover, in duodenal and gastric ulcer patients, basal acid output is of vagal origin and not related to serum gastrin 54 .…”

Section: Discussionmentioning

confidence: 99%

“…The association between emotional disorders, particularly depression, and peptic ulcer disease, has been suggested in several studies, establishing a link between cholinergic hypersensitivity and this common disorder 10–16 . Stress‐related, uncompensated parasympathetic over‐activity, has also been hypothesized as a basis for acid‐related duodenal ulcer 17 . However, interest in these areas of research has waned with the discovery of H. pylori as a leading cause of peptic ulcer disease.…”

Section: Introductionmentioning

confidence: 99%

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Altered physiology of acid secretion in depression‐prone Flinders rats results in exacerbated NSAID and stress‐induced gastric damage

Padol

Wang

Hunt

2011

Neurogastroenterology Motil

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Altered physiology of acid secretion in depression‐prone Flinders rats results in exacerbated NSAID and stress‐induced gastric damage

Padol

Wang

Hunt

2011

Neurogastroenterology Motil

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Psychological Preparation for Gastroscopy: A Brief Intervention Reduces Patient Stress More than a Detailed Intervention

Fourie

Nell

1990

South African Journal of Psychology

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The efficacy of psychological preparation for gastroscopy was investigated by allocating 43 subjects presenting far routine diagnostic gastroscopy to three groups. Of these, eight received a detailed 40-minute preparation with information on the gastroscope, the examination procedure, sensations to be expected, and a variety of coping mechanisms, including relaxation techniques; 15 subjects had a 10-minute preparation in which brief procedural and sensory information were given, and two coping mechanisms described; 20 control subjects received no preparation. The briefly prepared subjects showed a decisive advantage over both the controls and the detailed preparation group in measures of mood and behavioural manifestations of stress. Implications of these findings are considered with regard to the emotional factors co-existing with gastric-duodenal ulcerative disease, particularly in a South African context, and for the cost-effective preparation of patients for this and other stressful medical procedures.Die effektiwiteit van sielkundige voorbereiding vir gastroskopie is ondersoek in 'n totaal van 43 pasiente wat vir roetine diagnostiese gastroskopie aangemeld het. Hulle is in drie groepe verdeel: Die eerste groep van agt persone het 'n gedetailleerde voorbereiding van 40 minute ontvang, met inligting oar die gastroskoop, die prosedure, verwagte sensasies en 'n verskeidenheid van hanteringsmeganismes. Die tweede groep van 15 persone het 'n kort voorbereiding van 10 minute ontvang en die kontrole groep (20 persone) het geen intervensie ontvang nie. Die groep wat die kort intervensie ontvang het, het ten opsigte van sowel buimanifestasies as stres, beter gevaar as beide die kontrolegroep en die groep wat die gedetailleerde voorbereiding ontvang het. Die implikasies van die studie word in verband gebring met die gepaardgaande emosionele faktore van gastro-duodenale ulseratiewe siekte, veral in 'n Suid-Afrikaanse konteks, asook 'n koste-effektiewe voorbereiding van pasiente vir hierdie en ander stresvolle mediese prosedures.

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A psychophysiological hypothesis on the aetiology of duodenal ulceration

Cited by 2 publications

References 15 publications

Altered physiology of acid secretion in depression‐prone Flinders rats results in exacerbated NSAID and stress‐induced gastric damage

Altered physiology of acid secretion in depression‐prone Flinders rats results in exacerbated NSAID and stress‐induced gastric damage

Psychological Preparation for Gastroscopy: A Brief Intervention Reduces Patient Stress More than a Detailed Intervention

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