In a prospective study to identify psychological factors affecting survival in cancer patients receiving radiation therapy, 101 consecutive patients were evaluated for anxiety, depression, and perception of the seriousness of the condition. In 3 years, the survivors were compared to the nonsurvivors. The survivors had significantly higher mean trait anxiety (p < 0.05) than the nonsurvivors. State anxiety and depression scores also tended to be higher in the survivors (p < 0.01). Self-assessment of the seriousness of their disease did not differentiate the two groups. The nonsurvivors had significantly more pain (p < 0.05). Within the nonsurvivor group, survival time was negatively correlated with state anxiety (p < 0.01), trait anxiety (p < 0.02), and depression (p < 0.01). In the nonsurvivors, women rated their condition to be significantly more serious than men (p < 0.01). Female nonsurvivors tended to rate their condition to be more serious than female survivors (p < 0.1), while male nonsurvivors rated their condition to be significantly less serious than male survivors (p < 0.01). Only among female nonsurvivors did the seriousness rating correlate significantly with anxiety (p < 0.01). The sex differences confirm our previous finding that men may tend to cope with cancer with more massive denial than women. We hypothesize that patients with higher anxiety and depression in the nonsurvivor group had a massive defensive failure, while those who had high anxiety levels in the survivor group had been more realistic about their disease. Our results imply that realistic anxiety may be adaptive in cancer patients, and that massive denial may be a poor prognostic sign, particularly among men. We also suggest, however, that anxiety per se is not necessarily a good prognostic sign in cancer patients but that if anxiety occurs in the context of massive defensive failure, it may be predictive of poorer outcome.