A PTFE helical capillary microreactor for the high throughput synthesis of monodisperse silica particles

Yang, Hui; Akinoglu, Eser Metin; Guo, Lihui; Jin, Mingliang; Zhou, Guofu; Giersig, Michael; Shui, Lingling; Mulvaney, Paul

doi:10.1016/j.cej.2020.126063

Cited by 17 publications

(6 citation statements)

References 31 publications

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“…The pH of the precursors was important to the hydrolysis reaction of generated SiO 2 shell, and it could be controlled by adjusting the concentration of ammonia water (cNH 3 ) in the sheath phase. [ 34 ] As a result, the average size of Fe 3 O 4 @SiO 2 nanoparticles grew almost linearly with cNH 3 , ranging from 130 to 350 nm in diameter (Figure 3d). The growth of average zeta potential was not linear to cNH 3 , and a peak appeared at cNH 3 = 0.803 mol L −1 , in which condition the pH was ≈9.…”

Section: Resultsmentioning

confidence: 91%

Microfluidic Continuous Modification of Magnetic Nanoparticles for Circulating Tumor Cell Capture and Isolation

Zhang

Lin

et al. 2023

Adv Materials Technologies

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Circulating Tumor Cells (CTCs) enrichment technology refers to medical approaches for capturing and isolating target tumor cells, which has drawn great attention owing to its applications in the clinic such as cancer diagnosis and prognosis. Magnetic nanoparticles have emerged as an important platform for CTCs capture and isolation. However, due to the inert surface nature, the molecular phenotype analysis of CTCs and identification sensitivity remain a huge challenge. Herein, an ultrasound‐activated microfluidic method is presented for rapid basic modification of magnetic nanoparticles, laying the foundation for further covalently binding of functional groups to capture CTCs. In this work, Fe3O4@SiO2 nanoparticles obtained from microfluidics are hybrid with folic acid for the capture and isolation of CTCs with folate receptors such as Hela cells. The usage of microfluidic technology to upgrade Fe3O4 nanoparticles provides the possibility for improving the detective efficiency of rare cells associated with malignancies, which sheds new light on future clinical applications.

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Section: Resultsmentioning

confidence: 91%

Microfluidic Continuous Modification of Magnetic Nanoparticles for Circulating Tumor Cell Capture and Isolation

Zhang

Lin

et al. 2023

Adv Materials Technologies

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“…[17][18][19][20] Recently, the continuous flow microreactor technology has been shown to be an efficient synthesis method. [21][22][23][24][25] Compared with the traditional stirring-mix method, microreactors have higher surface area-to-volume ratios and shorter characteristic transport paths, which ensure efficient heat and mass transfer rates and excellent mixing capabilities. [26][27][28] These are key factors for the nucleation and growth of nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Continuous and large-scale synthesis of Ni–Co PBA nanoparticles with a tunable particle size in a microreactor

Wang

Liu

et al. 2023

New J. Chem.

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“…In particular, micron‐sized silica particles can be used as the key spacer microsphere materials of liquid crystal panels 3 . The size distribution is a critical factor for silica particles to meet the application, 4 for which the required size range is very narrow, so the silica particles obtained from the synthesis process must be subjected to rigorous size classification 5,6 . Then, it is of great significance to study the size classification process of micron‐sized silica particles.…”

Section: Introductionmentioning

confidence: 99%

Study on the hydraulic classification characteristics of micron‐sized silica particles

Zhang

Tang

2023

Asia-Pacific J Chem Eng

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The present study investigates the motion characteristics of micron‐sized silica particles and how solid–water interaction regulates hydraulic classification. Two methods were evaluated for classifying micron‐sized silica particles. Using the small‐diameter cyclone for hydraulic classification of micron‐sized silica particles resulted in poor separation due to the short residence time of particles in the cyclone. Particle settling in still water showed that settling velocity, drag force, and virtual mass force increased with particle size, providing a basis for size classification. In the particle sedimentation process, drag force and gravity were dominant, with drag force reaching equilibrium with gravity in a fast time. The upward water flow was introduced to classify silica particles, with its superficial velocity between the settling terminal velocities of large and small particles, allowing large and small particles to flow to the overflow and underflow, respectively. The upward flow velocity was higher near the center of the flow field and lower near the wall, leading to a parabolic distribution pattern of the particle group along the radial position. In hydraulic sedimentation classification experiments of silica particles, the average particle size of the overflow sample was lower than that of the feed, and its size range was narrower, indicating the feasibility of hindered sedimentation by upward flow for classifying micron‐sized silica particles.

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A PTFE helical capillary microreactor for the high throughput synthesis of monodisperse silica particles

Cited by 17 publications

References 31 publications

Microfluidic Continuous Modification of Magnetic Nanoparticles for Circulating Tumor Cell Capture and Isolation

Microfluidic Continuous Modification of Magnetic Nanoparticles for Circulating Tumor Cell Capture and Isolation

Continuous and large-scale synthesis of Ni–Co PBA nanoparticles with a tunable particle size in a microreactor

Study on the hydraulic classification characteristics of micron‐sized silica particles

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