A public health perspective on mitigating the global burden of chronic liver disease

Abstract

Chronic liver disease (CLD) is a significant global health problem. Epidemiological trends do not show improvement in CLD incidence but rather a shift in etiologies, with steatotic liver disease (SLD) from metabolic dysfunction and alcohol becoming increasingly important causes. Consequently, there is a pressing need to develop a comprehensive public health approach for SLD. To that end, we propose a public health framework for preventing and controlling SLD. The framework is anchored on evidence linking physical inactivity, unhealthy dietary patterns, alcohol use, and obesity with both incidence and progression of SLD. Guided by the framework, we review examples of federal/state, community, and individual-level interventions with the potential to address these determinants of SLD. Ultimately, mitigating SLD’s burden requires primary risk factor reduction at multiple socioecological levels, by scaling up the World Health Organization’s “best buys”, in addition to developing and implementing SLD specific control interventions.

Establishment of an easy-to-construct liver injury mouse model for longitudinal analysis by drinking-water administration of MDA

“…Hepatic dysfunction, a condition with severe implications such as liver cancer and failure, has diverse causes, including drugs, alcohol, and hepatitis viruses (1,2). Despite its substantial public health impact, treatment options are limited, and there is a lack of medicine-based therapeutic approaches.…”