From the 19th century, the theory of permutation polynomial over finite fields, that are arose in the work of Hermite and Dickson, has drawn general attention. Permutation polynomials over finite fields are an active area of research due to their rising applications in mathematics and engineering. The last three decades has seen rapid progress on the research on permutation polynomials due to their diverse applications in cryptography, coding theory, finite geometry, combinatorics and many more areas of mathematics and engineering. For this reason, the study of permutation polynomials is important nowadays. In this chapter, we propose some new problems in connection to permutation polynomials over finite fields by the help of prime numbers.