A pure nanoICG-based homogeneous lipiodol formulation: toward precise surgical navigation of primary liver cancer after long-term transcatheter arterial embolization

A clinical trial of super-stable homogeneous lipiodol-nanoICG formulation-guided precise fluorescent laparoscopic hepatocellular carcinoma resection

“…To seamlessly integrate the diagnosis and treatment of HCC by combining the advantages of preoperative TAE and nanoICG, a critical problem had to be solved: how to realize the long-term, stable, and uniform dispersion of amphiphilic ICG in lipiodol. In previous study, we constructed a super-stable, homogeneous and intermixed formulation technology in which the drug molecule could be homogeneously dispersed in lipiodol [ 15 , 18 , 19 ]. The SHIFT&nanoICG formulation prepared by SHIFT showed excellent dispersibility and stability (Fig.…”

“…6 M–O). This excellent and accurate fluorescence performance was a result of the excellent photobleaching resistance, enhanced permeability, the retention effect of nanoICG, the excellent stability and uniformity of SHIFT&nanoICG, and the accurate passive targeting of TAE [ 15 , 19 , 30 , 33 ]. In particular, the trace amount of SHIFT&nanoICG deposited in the normal liver tissue around the tumor was metabolized 2 weeks after TAE [ 34 ].…”

“…In our previous work, ICG nanoparticles (nanoICG) were produced by SPFT to improve the optics and water/thermal stability of the ICG molecule and effectively avoid the decomposition and clearance in vivo . After being integrated with lipiodol via SHIFT, the nanoICG performed an excellent tumor-specific deposition to visualize the tumor regions for precise resection in VX2 orthotopic hepatocarcinoma models [ 19 ].…”

Metal Ion-Based Supramolecular Self-Assembly for Cancer Theranostics

“…The tumor environment-triggered coassembly strategy can overcome the critical issues of precise delivery and address the requirements to monitor therapeutic effects with non-invasive quantitative diagnosis ( Chu et al, 2017 ). Ferric (Fe 3+ ), zinc (Zn 2+ ), and manganese (Mn 2+ ) ions have been confirmed to interact with sulfonic acid and Lewis base groups at the terminal of Indocyanine green (ICG), a US FDA-approved theranostic dye for clinical use, to self-assemble into multi-level supramolecular systems ( Shang et al, 2017 ; Chu et al, 2019 ; Zhang et al, 2021 ). Such metal-assisted multi-level self-assembly strategies offer significant advantages with respect to fabrication of hybrid imaging techniques that combine therapy for multimodal imaging-guided theranostics ( Zhang et al, 2020 ; Du et al, 2021 ).…”

State-of-the-art of nuclear medicine and molecular imaging in China: after the first 66 years (1956–2022)

“…In the final published special issue, there are more than 40 articles total, which include 6 review articles [ 4 , 6 – 10 ] and this editorial, with the remaining being research articles. According to the standard EJNMMI list of topics, these research articles were divided into the following categories: advanced image analyses [ 11 – 13 ], preclinical imaging [ 14 – 26 ], translational research [ 27 – 30 ], neurology [ 31 , 32 ], cardiology [ 33 ], and oncology [ 34 – 47 ]. Due to the large number of accepted manuscripts, which is significantly more than the typical number of articles per EJNMMI issue, many invited contributions were published in various issues before this EJNMMI special issue, which include 2 review articles [ 48 , 49 ], many research articles [ 50 – 62 ], and 1 invited editorial [ 63 ].…”