A Purified Serum Glycopeptide from Controls and Cystic Fibrosis Patients. II. Comparison of their Immunologic Properties Using Monoclonal Antibodies

Blitzer, Miriam G.; Shapira, Emmanuel

doi:10.1203/00006450-198211000-00007

Cited by 2 publications

(1 citation statement)

References 6 publications

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“…Glucosamine, a monosaccharide that is commerically available, was shown to be a suitable substrate for the diagnosis of this syndrome in fibroblasts (4). In this report we describe the use of purified ['4C]glucosamine as substrate, and leukocytes as enzyme source for the diagnosis of homozygous and heterozygous individuals.…”

Section: Discussionmentioning

confidence: 99%

A Purified Serum Glycopeptide from Controls and Cystic Fibrosis Patients. III. The Association of the Ciliary Dyskinetic Activity with the Oligosaccharide Component

Blitzer

Shapira

1984

Pediatr Res

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Section: Discussionmentioning

confidence: 99%

A Purified Serum Glycopeptide from Controls and Cystic Fibrosis Patients. III. The Association of the Ciliary Dyskinetic Activity with the Oligosaccharide Component

Blitzer

Shapira

1984

Pediatr Res

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Usefulness of serum IgG4 in the diagnosis and follow up of autoimmune pancreatitis: A systematic literature review and meta‐analysis

Morselli-Labate

Pezzilli

2009

J of Gastro and Hepatol

126

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High circulating serum immunoglobulin G4 (IgG4) levels have been proposed as a marker of autoimmune pancreatitis (AIP). The aim of the present study was to review the data existing in the English literature on the usefulness of the IgG4 serum levels in the diagnosis and follow up of patients with AIP. A total of 159 patients with AIP and 1099 controls were described in seven selected papers reporting the usefulness of serum IgG4 in diagnosing AIP. In total, 304 controls had pancreatic cancer, 96 had autoimmune diseases, and the remaining 699 had other conditions. The summary receiver-operating characteristic curve analysis was carried out by means of Meta-DiSc open-access software. Serum IgG4 showed good accuracy in distinguishing between AIP and the overall controls, pancreatic cancer and other autoimmune diseases (area under the curve [Ϯ SE]: 0.920 Ϯ 0.073, 0.914 Ϯ 0.191, and 0.949 Ϯ 0.024, respectively). The studies analyzed showed significantly heterogeneous specificity values in each of the three analyses performed. The analysis of the four studies comparing AIP and pancreatic cancers also showed significantly heterogeneous values of sensitivities and odds ratios. Regarding the usefulness of IgG4 as a marker of efficacy of steroid treatment, a decrease in the serum concentrations of IgG4 was found in the four available studies. The serum IgG4 subclass is a good marker of AIP, and its determination should be included in the diagnostic workup of this disease. However, the heterogeneity of the studies published until now means that more studies are necessary in order to better evaluate the true accuracy of IgG4 in discriminating AIP versus other autoimmune diseases.

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A Purified Serum Glycopeptide from Controls and Cystic Fibrosis Patients. II. Comparison of their Immunologic Properties Using Monoclonal Antibodies

Cited by 2 publications

References 6 publications

A Purified Serum Glycopeptide from Controls and Cystic Fibrosis Patients. III. The Association of the Ciliary Dyskinetic Activity with the Oligosaccharide Component

A Purified Serum Glycopeptide from Controls and Cystic Fibrosis Patients. III. The Association of the Ciliary Dyskinetic Activity with the Oligosaccharide Component

Usefulness of serum IgG4 in the diagnosis and follow up of autoimmune pancreatitis: A systematic literature review and meta‐analysis

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