2020
DOI: 10.1007/s12272-020-01246-x
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A pursuit of Staphylococcus aureus continues: a role of persister cells

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Cited by 48 publications
(36 citation statements)
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“…Another particular trait of S. aureus that makes it notoriously difficult to combat in the clinical setting is phenotypic heterogeneity. An example of this is the phenomenon of persister cells, where sub-populations of S. aureus gain a resistance phenotype against antibiotic treatment resulting from arrested growth [ 10 ]. Persister cells may be generated in numerous ways, one of which is the formation of Small Colony Variants (SCVs) that are characterized by auxotrophy for various compounds involved in the electron transport chain and slow growth, allowing them to escape the effects of many antibiotics [ 11 , 12 ].…”
Section: Introductionmentioning
confidence: 99%
“…Another particular trait of S. aureus that makes it notoriously difficult to combat in the clinical setting is phenotypic heterogeneity. An example of this is the phenomenon of persister cells, where sub-populations of S. aureus gain a resistance phenotype against antibiotic treatment resulting from arrested growth [ 10 ]. Persister cells may be generated in numerous ways, one of which is the formation of Small Colony Variants (SCVs) that are characterized by auxotrophy for various compounds involved in the electron transport chain and slow growth, allowing them to escape the effects of many antibiotics [ 11 , 12 ].…”
Section: Introductionmentioning
confidence: 99%
“…When the body has low resistance or deep wounds, S. aureus easily invades and causes infection. Infection with S. aureus during hospital surgery easily causes pneumonia, pseudomembranous enteritis, pericarditis, and even systemic infections such as sepsis [27]. However, S. aureus is resistant to the currently available antibiotics, so the existing antibiotic drugs cannot meet the treatment needs.…”
Section: Discussionmentioning
confidence: 99%
“…SCVs are defined as slow-growing pin-prick-sized colonies that are less sensitive to antibiotic treatments compared to wildtype pathogens and can revert to a normal phonotype after stress removal [97]. Since the first report about associations between SCVs and persistent infection in 1995 [98], researchers have found that SCVs exist in a wide range of bacteria and are linked to several chronic diseases [99]. In addition, SCVs can promote pathogenicity by promoting biofilm formation [81], presumably facilitated by overexpressing adhesins [100] and by impairing host immunity via necroptosis induction [101].…”
Section: Small Colony Variantsmentioning
confidence: 99%
“…SCVs form in Salmonella planktonic and biofilm cultures when exposed to a high concentration of ciprofloxacin and ceftazidime [106]. Moreover, the formation of SCVs is recognized as part of persistent Salmonella [99] infection. Such SCVs, localized within host cells, can last for several weeks and contribute to a relapse of infection.…”
Section: Small Colony Variantsmentioning
confidence: 99%