A Putative Role of Vasopressin/Oxytocin-Type Neuropeptide in Osmoregulation and Feeding Inhibition of Apostichopus japonicus

Cong, Xiao; Liu, Huachen; Zheng, Yingqiu; Chen, Muyan

doi:10.3390/ijms241814358

Cited by 5 publications

(1 citation statement)

References 97 publications

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“…In A. japonicus, we found that the vasopressin/oxytocin-type neuropeptide (VP/OT) has a strong contractile effect on a variety of muscle tissues, including LMBW, intestinal muscle, and tentacles. Ca 2+ deprivation experiments have shown that VP/OT-induced contraction is dependent on extracellular Ca 2+ influx [150]. However, the channel that mediates Ca 2+ influx and the intracellular signaling pathway that activates it are still unknown.…”

Section: Neuropeptidesmentioning

confidence: 99%

Morphology and Chemical Messenger Regulation of Echinoderm Muscles

Liu,

Chen

2023

Biology

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The muscular systems of echinoderms play important roles in various physiological and behavioral processes, including feeding, reproduction, movement, respiration, and excretion. Like vertebrates, echinoderm muscle systems can be subdivided into two major divisions, somatic and visceral musculature. The former usually has a myoepithelial organization, while the latter contains muscle bundles formed by the aggregation of myocytes. Neurons and their processes are also detected between these myoepithelial cells and myocytes, which are capable of releasing a variety of neurotransmitters and neuropeptides to regulate muscle activity. Although many studies have reported the pharmacological effects of these chemical messengers on various muscles of echinoderms, there has been limited research on their receptors and their signaling pathways. The muscle physiology of echinoderms is similar to that of chordates, both of which have the deuterostome mode of development. Studies of muscle regulation in echinoderms can provide new insights into the evolution of myoregulatory systems in deuterostomes.

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Section: Neuropeptidesmentioning

confidence: 99%

Morphology and Chemical Messenger Regulation of Echinoderm Muscles

Liu,

Chen

2023

Biology

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Feeding and growth are regulated by light and opsins-mediated phototransduction in sea cucumber Apostichopus japonicus

Liu,

Cong,

Wang

et al. 2025

Aquaculture

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Functional characterisation of neuropeptides that act as ligands for both calcitonin-type and pigment-dispersing factor-type receptors in a deuterostome

Cong,

Liu,

Liu

et al. 2024

Preprint

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The calcitonin (CT) family of related peptides exert their diverse physiological effects in mammals via two G-protein coupled receptors, CTR and the CTR-like receptor CLR. Analysis of the phylogenetic distribution of CT-type signaling has revealed the occurrence of CT-type peptides and CTR/CLR-type proteins in deuterostome and protostome invertebrates. Furthermore, experimental studies have revealed that in the protostomeDrosophila melanogasterthe CT-like peptide DH31can act as a ligand for a CTR/CLR-type receptor and a pigment-dispersing factor (PDF) receptor. Here we investigated the signaling mechanisms and functions of CT-type neuropeptides in a deuterostome invertebrate, the sea cucumberApostichopus japonicus(phylum Echinodermata). InA. japonicus,a single gene encodes two CT-type peptides (AjCT1 and AjCT2), both of which act as ligands for a CTR/CLR-type receptor (AjCTR) and two PDF-type receptors (AjPDFR1, AjPDFR2), but with differential activation of downstream cAMP/PKA, Gαq/Ca2+/PKC and ERK1/2 signaling pathways. Analysis of the expression of the gene encoding AjCT1 and AjCT2 revealed transcripts in a variety of organ systems, but with highest expression in the circumoral nervous system.In vitropharmacological experiments revealed that AjCT1 and/or AjCT2 cause dose-dependent relaxation of longitudinal body wall muscle and intestine preparations. Furthermore,in vivopharmacological experiments and loss-of-function tests revealed a potential physiological role for AjCT2 signaling in promoting feeding and growth inA. japonicus. This is the first study to obtain evidence that CT-type peptides can act as ligands for both CTR/CLR-type and PDF-type receptors in a deuterostome. Furthermore, because of the economic importance ofA. japonicusas a foodstuff, discovery of the potential role for CT-type peptides as regulators of feeding and growth in this species may provide a basis for practical applications in aquaculture.Graphical abstractA schematic showing proposed molecular mechanisms by which CT-type neuropeptides regulate feeding and growth inA. japonicus. AjCT1 and AjCT2 are represented by purple and yellow circles, respectively. For cell signaling, black arrows indicate that this process is activated, whilst the pink arrow indicates that the ERK1/2 is activated in the AjCT1/AjPDFR1, AjCT2/AjPDFR1 and AjCT2/AjPDFR2 signaling pathways.

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A Putative Role of Vasopressin/Oxytocin-Type Neuropeptide in Osmoregulation and Feeding Inhibition of Apostichopus japonicus

Cited by 5 publications

References 97 publications

Morphology and Chemical Messenger Regulation of Echinoderm Muscles

Morphology and Chemical Messenger Regulation of Echinoderm Muscles

Feeding and growth are regulated by light and opsins-mediated phototransduction in sea cucumber Apostichopus japonicus

Functional characterisation of neuropeptides that act as ligands for both calcitonin-type and pigment-dispersing factor-type receptors in a deuterostome

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