Background: The use of Anabolic-androgenic steroids (AAS) among the non-competitive weightlifting community has increased considerably in the UK in recent years, presenting a public health issue. The motives behind use have received considerable attention, with motivations linked to body dissatisfaction, low self-esteem, and more recently, muscle dysmorphia (MD). However, the causal roles of MD and self-esteem in AAS use remain unclear. Therefore, this paper examines the origins and changes to motivations in long-term users.Methods: A qualitative study recruited eight male weightlifters from a needle exchange programme in South Wales, UK. Participants were interviewed about their initial introduction to AAS and their motivations for initial and continued use. Results: The interview data confirmed the importance of the training community in providing advice and guidance on AAS. Those interviewed cited some motivations for use which included self-esteem, body dissatisfaction, MD, social acceptance, and age-related concerns. Implicit in these motivations was a psychological addiction to the positive effects following AAS use, which for some men, had led to psychological dependency and body image pathology. Conclusions: The changes in motivations described by the AAS users provide key insights into the complex nature of AAS use. For some men, low self-esteem, body dissatisfaction and MD precede AAS use, and for others, they are consequences of use. These findings have significant implications for future research and public health initiatives.