Metabolism is a challenging subject
for bioscience students due
to the intrinsic complexity of the metabolic network, as well as that
of the overlapping mechanisms of metabolic regulation. Collaborative
learning based on a problem-based learning approach can help students
to successfully learn and understand metabolism. In the present article,
we propose a selection of exercises, problems, and cases aimed to
focus students’ attention on the scientific work made by Sir
Hans Krebs and his collaborators to elucidate four main metabolic
cycles, as well as on the study of these cycles, their regulation,
and their metabolic integration. The objectives, the tools, and the
implementation of this proposal are described, and the results obtained
during its first implementation with volunteer students enrolled in
two courses on metabolic regulation at our university are presented
and discussed. These volunteer students signed a learning contract
and were randomly distributed in small groups (3–4 students
each). Application of this collaborative learning activity to our
classrooms has been very satisfactory, as evidenced by an improvement
in the volunteers’ academic performance and a very positive
perception by most of them, who declared to be “very satisfied”
or “satisfied” with their experience and felt that they
had learned more.